Journal ArticleDOI
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
Jürgen Bernhagen,Regina M. Krohn,Hongqi Lue,Julia L. Gregory,Alma Zernecke,Rory R. Koenen,Manfred Dewor,Ivan T. Georgiev,Andreas Schober,Lin Leng,Teake Kooistra,Gunter Fingerle-Rowson,Pietro Ghezzi,Robert Kleemann,Shaun R. McColl,Richard Bucala,Michael J. Hickey,Christian Weber +17 more
TLDR
Targeting MIF in individuals with manifest atherosclerosis can potentially be used to treat this condition and displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis.Abstract:
The cytokine macrophage migration inhibitory factor (MIF) plays a critical role in inflammatory diseases and atherogenesis. We identify the chemokine receptors CXCR2 and CXCR4 as functional receptors for MIF. MIF triggered G αi- and integrin-dependent arrest and chemotaxis of monocytes and T cells, rapid integrin activation and calcium influx through CXCR2 or CXCR4. MIF competed with cognate ligands for CXCR4 and CXCR2 binding, and directly bound to CXCR2. CXCR2 and CD74 formed a receptor complex, and monocyte arrest elicited by MIF in inflamed or atherosclerotic arteries involved both CXCR2 and CD74. In vivo, Mif deficiency impaired monocyte adhesion to the arterial wall in atherosclerosis-prone mice, and MIF-induced leukocyte recruitment required Il8rb (which encodes Cxcr2). Blockade of Mif but not of canonical ligands of Cxcr2 or Cxcr4 in mice with advanced atherosclerosis led to plaque regression and reduced monocyte and T-cell content in plaques. By activating both CXCR2 and CXCR4, MIF displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis. Targeting MIF in individuals with manifest atherosclerosis can potentially be used to treat this condition. © 2007 Nature Publishing Group.read more
Citations
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Journal ArticleDOI
Macrophage migration inhibitory factor-A potential diagnostic tool in severe burn injuries?
Gerrit Grieb,David Simons,Andrzej Piatkowski,Jürgen Bernhagen,Guy C. M. Steffens,Norbert Pallua +5 more
TL;DR: The combined determination of MIF and PCT might, therefore, be useful to discriminate between post-burn inflammation and systemic inflammatory response syndrome (SIRS) or sepsis with lethal outcome.
Journal ArticleDOI
Type 2 diabetes is not associated with an altered plaque phenotype among patients undergoing carotid revascularization. A histological analysis of 1455 carotid plaques
Vincent P. W. Scholtes,Wouter Peeters,Guus W. van Lammeren,Dominic P.J. Howard,Jean-Paul P.M. de Vries,Gert J. de Borst,Jessica Redgrave,Hans Kemperman,Casper G. Schalkwijk,Hester M. den Ruijter,Dominique P.V. de Kleijn,Frans L. Moll,Peter M. Rothwell,Gerard Pasterkamp +13 more
TL;DR: In patients suffering from significant carotid artery disease, diabetes does not appear to be associated with specific atherosclerotic plaque characteristics, and no associations between diabetes and histological plaque characteristics were observed.
Journal ArticleDOI
Anti-Allergic and Anti-Inflammatory Effects and Molecular Mechanisms of Thioredoxin on Respiratory System Diseases.
Jiedong Zhou,Cuixue Wang,JiaLin Wu,Atsushi Fukunaga,ZuSheng Cheng,Jinquan Wang,Akira Yamauchi,Junji Yodoi,Hai Tian +8 more
TL;DR: It is demonstrated that systemic administration and transgenic overexpression of TRX is useful in a wide variety of in vivo inflammatory respiratory diseases models, and its anti-allergic and anti-inflammatory molecular mechanism is discussed in detail.
Journal ArticleDOI
Emerging therapeutic biomarkers of autoimmune hepatitis and their impact on current and future management
TL;DR: Each of the candidate biomarkers is close to the putative pathogenic mechanisms of autoimmune hepatitis, and each has attributes that support its potential role as a surrogate marker of inflammatory activity that can be monitored during treatment.
Journal ArticleDOI
Macrophage immigration inhibitory factor promotes cell proliferation and inhibits apoptosis of cervical adenocarcinoma.
TL;DR: MIF expression was positively related to ADC clinicopathological features of carcinoma diameter and lymph node metastasis and indicated that MIF knockdown inhibited cell proliferation and induced apoptosis in ADC cells.
References
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