Journal ArticleDOI
MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment
Jürgen Bernhagen,Regina M. Krohn,Hongqi Lue,Julia L. Gregory,Alma Zernecke,Rory R. Koenen,Manfred Dewor,Ivan T. Georgiev,Andreas Schober,Lin Leng,Teake Kooistra,Gunter Fingerle-Rowson,Pietro Ghezzi,Robert Kleemann,Shaun R. McColl,Richard Bucala,Michael J. Hickey,Christian Weber +17 more
TLDR
Targeting MIF in individuals with manifest atherosclerosis can potentially be used to treat this condition and displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis.Abstract:
The cytokine macrophage migration inhibitory factor (MIF) plays a critical role in inflammatory diseases and atherogenesis. We identify the chemokine receptors CXCR2 and CXCR4 as functional receptors for MIF. MIF triggered G αi- and integrin-dependent arrest and chemotaxis of monocytes and T cells, rapid integrin activation and calcium influx through CXCR2 or CXCR4. MIF competed with cognate ligands for CXCR4 and CXCR2 binding, and directly bound to CXCR2. CXCR2 and CD74 formed a receptor complex, and monocyte arrest elicited by MIF in inflamed or atherosclerotic arteries involved both CXCR2 and CD74. In vivo, Mif deficiency impaired monocyte adhesion to the arterial wall in atherosclerosis-prone mice, and MIF-induced leukocyte recruitment required Il8rb (which encodes Cxcr2). Blockade of Mif but not of canonical ligands of Cxcr2 or Cxcr4 in mice with advanced atherosclerosis led to plaque regression and reduced monocyte and T-cell content in plaques. By activating both CXCR2 and CXCR4, MIF displays chemokine-like functions and acts as a major regulator of inflammatory cell recruitment and atherogenesis. Targeting MIF in individuals with manifest atherosclerosis can potentially be used to treat this condition. © 2007 Nature Publishing Group.read more
Citations
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Journal ArticleDOI
Admission macrophage migration inhibitory factor predicts long-term prognosis in patients with ST-elevation myocardial infarction
Xiangning Deng,Xinyu Wang,Haiyi Yu,Shaomin Chen,Xinye Xu,Wei Huai,Gui-Hua Liu,Qing-Bian Ma,Youyi Zhang,Anthony M. Dart,Anthony M. Dart,Xiao-Jun Du,Wei Gao +12 more
TL;DR: STEMI patients with high admission MIF level experienced a poorer recovery of cardiac function and worse long-term adverse outcomes, and combination of Nt-proBNP with MIF further improves prognostic capability.
Journal ArticleDOI
The Effects of Hypoxia on the Immune-Modulatory Properties of Bone Marrow-Derived Mesenchymal Stromal Cells.
Zsolt Fábián,Zsolt Fábián +1 more
TL;DR: Current knowledge on the effect of hypoxia on the physiology of bone marrow-derived mesenchymal stromal cells, one of the most popular tools of practical cellular therapy, in the context of their immune-modulatory capacity is examined.
Journal ArticleDOI
Overexpression of CXCR1/CXCR2 on mesenchymal stromal cells may be an effective treatment for acute myocardial infarction.
TL;DR: It is hypothesized that the application of IL-8 will enhance the recruitment of overexpressing CXCR1/CXCR2 MSC to sites of degenerated tissue of myocardium, decreasing the ischemic region and improving cardiac function.
Journal ArticleDOI
Macrophage Migration Inhibitory Factor Levels in Gingival Crevicular Fluid, Saliva, and Serum of Chronic Periodontitis Patients
Yveth Marlene Ortiz-García,Trinidad García-Iglesias,Gabriela Morales-Velazquez,Blanca Patricia Lazalde-Ramos,Guillermo Moisés Zúñiga-González,Ramón Guillermo Ortiz-García,Ana Lourdes Zamora-Perez +6 more
TL;DR: Evaluated MIF levels in gingival crevicular fluid, saliva, and serum of CP patients demonstrated significant high levels of MIF in saliva compared with GCF and serum in both study groups and a positive correlation was found between clinical signs and MIF concentration in GCF.
Journal ArticleDOI
Role of Macrophage Migration Inhibitory Factor in Granulomatosis With Polyangiitis.
Antoine G. Sreih,Rana Ezzedine,Lin Leng,Juan Fan,Jie Yao,Duncan Reid,Marta Piecychna,Simon Carette,David Cuthbertson,Paul F. Dellaripa,Gary S. Hoffman,Nader Khalidi,Curry L. Koening,Carol A. Langford,Alfred Mahr,Carol A. McAlear,Kathleen Maksimowicz-McKinnon,Paul A. Monach,Philip Seo,Ulrich Specks,E. William St. Clair,John H. Stone,Steven R. Ytterberg,Jeffrey C. Edberg,Peter A. Merkel,Richard Bucala +25 more
TL;DR: To examine the association between macrophage migration inhibitory factor promoter polymorphisms and granulomatosis with polyangiitis (GPA) in human subjects, and to assess the role of MIF in a murine model of granulOMatous vasculitis.
References
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