Molecular Evolution of Human Coronavirus Genomes
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TLDR
This review of recent findings on the molecular evolution of HCoV genomes is summarized, with special attention to recombination and adaptive events that generated new viral species and contributed to host shifts and to H coV emergence.Citations
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The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2
Alexander E. Gorbalenya,Susan C. Baker,Ralph S. Baric,Raoul J. de Groot,Christian Drosten,Anastasia A. Gulyaeva,Bart L. Haagmans,Chris Lauber,Andrey M. Leontovich,Benjamin W. Neuman,Dmitry Penzar,Stanley Perlman,Leo L.M. Poon,Dmitry V. Samborskiy,Igor A. Sidorov,Isabel Sola,John Ziebuhr +16 more
TL;DR: The independent zoonotic transmission of SARS-CoV and SARS -CoV-2 highlights the need for studying viruses at the species level to complement research focused on individual pathogenic viruses of immediate significance.
Journal ArticleDOI
Origin and evolution of pathogenic coronaviruses
Jie Cui,Fang Li,Zhengli Shi +2 more
TL;DR: The viral factors that enabled the emergence of diseases such as severe acute respiratory syndrome and Middle East respiratory syndrome are explored and the diversity and potential of bat-borne coronaviruses are highlighted.
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Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2
Yadi Zhou,Yuan Hou,Jiayu Shen,Yin Huang,William R. Martin,Feixiong Cheng,Feixiong Cheng,Feixiong Cheng +7 more
TL;DR: This study presents an integrative, antiviral drug repurposing methodology implementing a systems pharmacology-based network medicine platform, quantifying the interplay between the HCoV–host interactome and drug targets in the human protein–protein interaction network.
Journal ArticleDOI
Another Decade, Another Coronavirus.
TL;DR: For the third time in as many decades, a zoonotic coronavirus has crossed species to infect human populations and this virus, provisionally called 2019-nCoV, was first identified in Wuhan, China, in 2016.
Journal ArticleDOI
Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic.
Maciej F. Boni,Philippe Lemey,Xiaowei Jiang,Tommy Tsan-Yuk Lam,Blair W. Perry,Todd A. Castoe,Andrew Rambaut,David Robertson +7 more
TL;DR: SARS-CoV-2 itself is not a recombinant of any sarbecoviruses detected to date, and its receptor-binding motif appears to be an ancestral trait shared with bat viruses and not one acquired recently via recombination.
References
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New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0
Stéphane Guindon,Jean-François Dufayard,Vincent Lefort,Maria Anisimova,Wim Hordijk,Olivier Gascuel +5 more
TL;DR: A new algorithm to search the tree space with user-defined intensity using subtree pruning and regrafting topological moves and a new test to assess the support of the data for internal branches of a phylogeny are introduced.
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