Multi-site assessment of rapid, point-of-care antigen testing for the diagnosis of SARS-CoV-2 infection in a low-prevalence setting: A validation and implementation study
Stephen Muhi,Stephen Muhi,Nick Tayler,Nick Tayler,Tuyet Hoang,Susan A Ballard,Maryza Graham,Amanda Rojek,Jason C Kwong,Jason C Kwong,Jason A Trubiano,Olivia C Smibert,George P Drewett,Fiona L James,Emma Gardiner,Socheata Chea,Nicole Isles,Michelle Sait,Shivani Pasricha,George Taiaroa,Julie L. McAuley,Eloise Williams,Katherine B Gibney,Katherine B Gibney,Timothy P. Stinear,Katherine Bond,Katherine Bond,Sharon R Lewin,Sharon R Lewin,Sharon R Lewin,Mark Putland,Benjamin P Howden,Benjamin P Howden,Deborah A Williamson,Deborah A Williamson +34 more
- Vol. 9, pp 100115-100115
TLDR
In this paper, the authors evaluated the performance and implementation of rapid antigen-based SARS-CoV-2 testing in a setting with a low prevalence of COVID-19 infections, such as Australia.Abstract:
Background: In Australia, COVID-19 diagnosis relies on RT-PCR testing which is relatively costly and time-consuming To date, few studies have assessed the performance and implementation of rapid antigen-based SARS-CoV-2 testing in a setting with a low prevalence of COVID-19 infections, such as Australia Methods: This study recruited participants presenting for COVID-19 testing at three Melbourne metropolitan hospitals during a period of low COVID-19 prevalence The Abbott PanBioTM COVID-19 Ag point-of-care test was performed alongside RT-PCR In addition, participants with COVID-19 notified to the Victorian Government were invited to provide additional swabs to aid validation Implementation challenges were also documented Findings: The specificity of the Abbott PanBioTM COVID-19 Ag test was 9996% (95% CI 9973 - 100%) Sensitivity amongst participants with RT-PCR-confirmed infection was dependent upon the duration of symptoms reported, ranging from 773% (duration 1 to 33 days) to 100% in those within seven days of symptom onset A range of implementation challenges were identified which may inform future COVID-19 testing strategies in a low prevalence setting Interpretation: Given the high specificity, antigen-based tests may be most useful in rapidly triaging public health and hospital resources while expediting confirmatory RT-PCR testing Considering the limitations in test sensitivity and the potential for rapid transmission in susceptible populations, particularly in hospital settings, careful consideration is required for implementation of antigen testing in a low prevalence setting Funding: This work was funded by the Victorian Department of Health and Human Services The funder was not involved in data analysis or manuscript preparationread more
Citations
More filters
Posted ContentDOI
Accuracy of rapid point-of-care antigen-based diagnostics for SARS-CoV-2: an updated systematic review and meta-analysis with meta regression analyzing influencing factors
L. Bruemmer,Stephan Katzenschlager,Sean McGrath,S. Schmitz,Mary Gaeddert,C. Erdmann,Marc Bota,Martina Grilli,Jan Larmann,Markus A. Weigand,Nira R. Pollock,Aurélien Macé,Berra Erkosar,Samuel Carmona,Jilian A. Sacks,Stefano Ongarello,Claudia M. Denkinger +16 more
TL;DR: With viral load, as estimated by Ct-value, being the most influential factor on their sensitivity, Ag-RDTs are especially useful to detect persons with high viral load who are most likely to transmit the virus.
Journal ArticleDOI
Use of emerging testing technologies and approaches for SARS-CoV-2: review of literature and global experience in an Australian context.
Maryza Graham,Susan A Ballard,Shivani Pasricha,Belinda Lin,Tuyet Hoang,Timothy P. Stinear,Julian Druce,Mike Catton,Norelle L Sherry,Deborah A Williamson,Benjamin P Howden +10 more
TL;DR: In this paper, the authors present a review of emerging testing technologies for detection of SARS-CoV-2, including those that are rapid and can be used at point-of-care (POC), and those facilitating high throughput laboratory-based testing.
Journal ArticleDOI
Virus variant–specific clinical performance of SARS coronavirus two rapid antigen tests in point-of-care use, from November 2020 to January 2022
Isabell Wagenhäuser,Kerstin Knies,Daniela Hofmann,Vera Rauschenberger,Michael Eisenmann,Julia Reusch,A. Gabel,Sven Flemming,Oliver Andres,Nils Petri,Max S. Topp,Michael Papsdorf,M McDonogh,Raoul Verma-Führing,Agmal Scherzad,Daniel Zeller,H Böhm,Anja Gesierich,Anna Katharina Seitz,Michael Kiderlen,Micha Gawlik,Regina Taurines,Thomas Wurmb,Ralf-Ingo Ernestus,Johannes Forster,Dirk Weismann,Benedikt Weissbrich,Lars Dölken,Johannes G. Liese,Lars Kaderali,Oliver Kurzai,Ulrich Vogel,Manuel Krone +32 more
TL;DR: In this article , the authors compared the performance of antigen rapid diagnostic tests (RDTs) for SARS coronavirus 2 (SARS-CoV-2) among different VOCs.
Journal ArticleDOI
Combining rapid antigen testing and syndromic surveillance improves community-based COVID-19 detection in a low-income country
Fergus Chadwick,Jessica Gaffney Clark,Shayan Chowdhury,Tasnuva Mahbub Chowdhury,David J Pascall,Yacob Haddou,Joanna Andrecka,Mikolaj E. Kundegorski,Craig Wilkie,Eric Brum,Tahmina Shirin,A. S. M. Alamgir,Mahbubur Rahman,Ahmed Nawsher Alam,Farzana Islam Khan,Ben Swallow,Frances S. Mair,Janine B. Illian,Caroline Trotter,Davina L. Hill,Dirk Husmeier,Jason Matthiopoulos,Katie Hampson,Ayesha Sania +23 more
TL;DR: In this article , the authors examined how combining these approaches can improve surveillance for guiding interventions in low-income communities in Dhaka, Bangladesh, and showed that drawing on complementary strengths across rapid diagnostics, improves COVID-19 detection, and reduces false positive and -negative diagnoses to match local requirements; improvements achievable without additional expense, or changes for patients or practitioners.
References
More filters
Journal ArticleDOI
Research electronic data capture (REDCap)-A metadata-driven methodology and workflow process for providing translational research informatics support
Paul A. Harris,Robert W. Taylor,Robert J. Thielke,Jonathon Payne,Nathaniel Gonzalez,José G. Conde +5 more
TL;DR: Research electronic data capture (REDCap) is a novel workflow methodology and software solution designed for rapid development and deployment of electronic data Capture tools to support clinical and translational research.
Journal ArticleDOI
A simple method of estimating fifty per cent endpoints
Lowell J. Reed,H. Muench +1 more
Journal ArticleDOI
Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR.
Victor M. Corman,Olfert Landt,Marco Kaiser,Richard Molenkamp,Adam Meijer,Daniel K.W. Chu,Tobias Bleicker,Sebastian Brünink,Julia Schneider,Marie Luisa Schmidt,Daphne G.J.C. Mulders,Bart L. Haagmans,Bas van der Veer,Sharon van den Brink,Lisa Wijsman,Gabriel Goderski,Jean Louis Romette,Joanna Ellis,Maria Zambon,Malik Peiris,Herman Goossens,Chantal B.E.M. Reusken,Marion Koopmans,Christian Drosten +23 more
TL;DR: A validated diagnostic workflow for 2019-nCoV is presented, its design relying on close genetic relatedness of 2019- nCoV with SARS coronavirus, making use of synthetic nucleic acid technology.
Journal ArticleDOI
Association of Public Health Interventions With the Epidemiology of the COVID-19 Outbreak in Wuhan, China.
An Pan,Li Liu,Chaolong Wang,Huan Guo,Xingjie Hao,Qi Wang,Jiao Huang,Na He,Hongjie Yu,Xihong Lin,Sheng Wei,Tangchun Wu +11 more
TL;DR: A series of multifaceted public health interventions was temporally associated with improved control of the COVID-19 outbreak in Wuhan, China, and may inform public health policy in other countries and regions.
Related Papers (5)
Uncovering the Devaluation of Nursing Home Staff During COVID-19: Are We Fuelling the Next Health Care Crisis?
Katherine S. McGilton,Katherine S. McGilton,Astrid Escrig-Pinol,Adam L. Gordon,Charlene H. Chu,Franziska Zúñiga,Montserrat Gea Sanchez,Veronique Boscart,Julienne Meyer,Kirsten Corazzini,Alessandro Ferrari Jacinto,Karen Spilsbury,Annica Backman,Kezia Scales,Anette Fagertun,Bei Wu,David Edvardsson,Michael Lepore,Angela Y. M. Leung,Elena O. Siegel,Maiko Noguchi-Watanabe,Jing Wang,Barbara J. Bowers +22 more
A novel approach to offering additional genomic findings-A protocol to test a two-step approach in the healthcare system
Melissa Martyn,A Kanga-Parabia,Elly Lynch,Paul A. James,Ivan Macciocca,Alison H. Trainer,Jane Halliday,Louise Keogh,Janney Wale,Ingrid Winship,Michael Bogwitz,Giulia M Valente,Maie Walsh,Lilian Downie,David J. Amor,David J. Amor,Mathew Wallis,Fiona Cunningham,Matthew Burgess,Natasha J Brown,Anna Jarmolowicz,Sebastian Lunke,Ilias Goranitis,Clara Gaff +23 more