Open Access
Nanotools for Neuroscience and Brain Activity Mapping
A. Paul Alivisatos,Anne M. Andrews,Edward S. Boyden,Miyoung Chun,George M. Church,Karl Deisseroth,John P. Donoghue,Scott E. Fraser,Jennifer Lippincott-Schwartz,Loren L. Looger,Sotiris C. Masmanidis,Paul L. McEuen,Arto V. Nurmikko,Hongkun Park,Darcy S. Peterka,Clay Reid,Michael L. Roukes,Axel Scherer,Mark J. Schnitzer,Terrence J. Sejnowski,Kenneth L. Shepard,Doris Y. Tsao,Gina G. Turrigiano,Paul S. Weiss,Chris Xu,Rafael Yuste,Xiaowei Zhuang +26 more
TLDR
How recent developments in nanoscale analysis tools and in the design and synthesis of nanomaterials have generated optical, electrical, and chemical methods that can readily be adapted for use in neuroscience is discussed.Abstract:
Neuroscience is at a crossroads. Great effort is being invested into deciphering specific neural interactions and circuits. At the same time, there exist few general theories or principles that explain brain function. We attribute this disparity, in part, to limitations in current methodologies. Traditional neurophysiological approaches record the activities of one neuron or a few neurons at a time. Neurochemical approaches focus on single neurotransmitters. Yet, there is an increasing realization that neural circuits operate at emergent levels, where the interactions between hundreds or thousands of neurons, utilizing multiple chemical transmitters, generate functional states. Brains function at the nanoscale, so tools to study brains must ultimately operate at this scale, as well. Nanoscience and nanotechnology are poised to provide a rich toolkit of novel methods to explore brain function by enabling simultaneous measurement and manipulation of activity of thousands or even millions of neurons. We and ...read more
Citations
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Test-retest reliabilities of resting-state FMRI measurements in human brain functional connectomics: A systems neuroscience perspective
Xi-Nian Zuo,Xiu-Xia Xing +1 more
TL;DR: A meta-summary reliability analysis of seven common brain networks revealed that the heteromodal associative networks were mostly reliable across the seven networks, and observations can guide the use of reliable metrics and further improvement of test-retest reliability for other metics in functional connectomics.
Journal ArticleDOI
Syringe Injectable Electronics
Jia Liu,Tian-Ming Fu,Zengguang Cheng,Guosong Hong,Tao Zhou,Lihua Jin,Madhavi Duvvuri,Zhe Jiang,Peter B. Kruskal,Chong Xie,Zhigang Suo,Ying Fang,Charles M. Lieber +12 more
TL;DR: This work demonstrates the syringe injection of sub-micrometre-thick, centimetre-scale macroporous mesh electronics through needles with a diameter as small as 100 μm, and demonstrates several applications of syringe-injectable electronics as a general approach for interpenetrating flexible electronics with three-dimensional structures.
Journal ArticleDOI
Bismuth sulfide nanorods as a precision nanomedicine for in vivo multimodal imaging-guided photothermal therapy of tumor
Jing Liu,Xiaopeng Zheng,Liang Yan,Liangjun Zhou,Gan Tian,Wenyan Yin,Liming Wang,Ying Liu,Zhongbo Hu,Zhanjun Gu,Chunying Chen,Yuliang Zhao +11 more
TL;DR: As-prepared Bi(2)S(3) NRs possess ideal photothermal effect and contrast enhancement in MSOT/CT bimodal imaging, which makes them simultaneously act as "satellite" and "precision targeted weapon" for the visual guide to destruction of tumors in vivo.
Journal ArticleDOI
Drug discovery: a jump-start for electroceuticals.
TL;DR: Kristoffer Famm and colleagues unveil a multidisciplinary initiative to develop medicines that use electrical impulses to modulate the body's neural circuits.
Journal ArticleDOI
Aptamer–field-effect transistors overcome Debye length limitations for small-molecule sensing
Nako Nakatsuka,Kyung-Ae Yang,John M. Abendroth,Kevin M Cheung,Xiaobin Xu,Hongyan Yang,Chuanzhen Zhao,Bowen Zhu,You Seung Rim,Yang Yang,Paul S. Weiss,Milan N. Stojanovic,Anne M. Andrews,Anne M. Andrews +13 more
TL;DR: Sensing of charged and electroneutral targets (serotonin, dopamine, glucose, and sphingosine-1-phosphate) was enabled by specifically isolated aptameric stem-loop receptors, resulting in highly sensitive detection.
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Nanotools for Neuroscience and Brain Activity Mapping
A. Paul Alivisatos,Anne M. Andrews,Edward S. Boyden,Miyoung Chun,George M. Church,Karl Deisseroth,John P. Donoghue,Scott E. Fraser,Jennifer Lippincott-Schwartz,Loren L. Looger,Sotiris C. Masmanidis,Paul L. McEuen,Arto V. Nurmikko,Hongkun Park,Darcy S. Peterka,Clay Reid,Michael L. Roukes,Axel Scherer,Mark J. Schnitzer,Terrence J. Sejnowski,Kenneth L. Shepard,Doris Y. Tsao,Gina G. Turrigiano,Paul S. Weiss,Chris Xu,Rafael Yuste,Xiaowei Zhuang +26 more