Journal ArticleDOI
Neutrophil-mediated anticancer drug delivery for suppression of postoperative malignant glioma recurrence
Jingwei Xue,Zekai Zhao,Lei Zhang,Lingjing Xue,Shiyang Shen,Yajing Wen,Zhuoyuan Wei,Lu Wang,Ling-Yi Kong,Hongbin Sun,Qineng Ping,Ran Mo,Can Zhang +12 more
TLDR
It is shown that NEs carrying liposomes that contain paclitaxel (PTX) can penetrate the brain and suppress the recurrence of glioma in mice whose tumour has been resected surgically, and this NE-mediated delivery of drugs efficiently slows the recurrent growth of tumours.Abstract:
Cell-mediated drug-delivery systems have received considerable attention for their enhanced therapeutic specificity and efficacy in cancer treatment. Neutrophils (NEs), the most abundant type of immune cells, are known to penetrate inflamed brain tumours. Here we show that NEs carrying liposomes that contain paclitaxel (PTX) can penetrate the brain and suppress the recurrence of glioma in mice whose tumour has been resected surgically. Inflammatory factors released after tumour resection guide the movement of the NEs into the inflamed brain. The highly concentrated inflammatory signals in the brain trigger the release of liposomal PTX from the NEs, which allows delivery of PTX into the remaining invading tumour cells. We show that this NE-mediated delivery of drugs efficiently slows the recurrent growth of tumours, with significantly improved survival rates, but does not completely inhibit the regrowth of tumours.read more
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Current Challenges and Opportunities in Treating Glioblastoma
TL;DR: Novel drug delivery methods, including nanoparticles and prodrugs and computational multi-parameter optimization to assess the blood-brain barrier (BBB) permeability of small molecules in clinical trials for GBM treatment are discussed.
Journal ArticleDOI
Recent progress in drug delivery
Chong Li,Jiancheng Wang,Yiguang Wang,Huile Gao,Gang Wei,Yongzhuo Huang,Haijun Yu,Yong Gan,Yongjun Wang,Lin Mei,Huabing Chen,Haiyan Hu,Zhiping Zhang,Yiguang Jin +13 more
TL;DR: This review provides a concise overview of current progress in this research area through its focus on the delivery strategies, construction techniques and specific examples.
Journal ArticleDOI
Targeting Strategies for Tissue-Specific Drug Delivery.
TL;DR: Key advances and emerging concepts for tissue-specific drug delivery approaches and their clinical translation are discussed.
Journal ArticleDOI
Neutrophils as emerging therapeutic targets
TL;DR: An overview of the biological and pathological functions of neutrophils is provided, assessing emerging strategies to therapeutically target neutrophil function and agents currently under investigation.
Journal ArticleDOI
Emerging blood–brain-barrier-crossing nanotechnology for brain cancer theranostics
TL;DR: A comprehensive review on the latest remarkable advances in BBB-crossing nanotechnology, with an emphasis on the judicious design of multifunctional nanoplatforms for effective BBB penetration, efficient tumour accumulation, precise tumour imaging, and significant tumour inhibition of brain cancer.
References
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Neutrophil extracellular traps kill bacteria
Volker Brinkmann,Ulrike Reichard,Christian Goosmann,Beatrix Fauler,Yvonne Uhlemann,David S. Weiss,Yvette Weinrauch,Yvette Weinrauch,Arturo Zychlinsky +8 more
TL;DR: It is described that, upon activation, neutrophils release granule proteins and chromatin that together form extracellular fibers that bind Gram-positive and -negative bacteria, which degrade virulence factors and kill bacteria.
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Nanocarriers as an emerging platform for cancer therapy
Dan Peer,Jeffrey M. Karp,Jeffrey M. Karp,Seungpyo Hong,Omid C. Farokhzad,Rimona Margalit,Robert Langer +6 more
TL;DR: The arsenal of nanocarriers and molecules available for selective tumour targeting, and the challenges in cancer treatment are detailed and emphasized.
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Getting to the site of inflammation: the leukocyte adhesion cascade updated
TL;DR: This Review focuses on new aspects of one of the central paradigms of inflammation and immunity — the leukocyte adhesion cascade.
Journal ArticleDOI
Neutrophil recruitment and function in health and inflammation
Elzbieta Kolaczkowska,Paul Kubes +1 more
TL;DR: The key features of the life of a neutrophil are discussed, from its release from bone marrow to its death, and the mechanisms that are used by neutrophils to promote protective or pathological immune responses at different sites are explained.
Journal ArticleDOI
Delivering nanomedicine to solid tumors
TL;DR: In this paper, the authors review the barriers to the delivery of cancer therapeutics and summarize strategies that have been developed to overcome these barriers and discuss design considerations for optimizing the nanoparticles to tumors.
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