New Gatekeepers of Reproduction: GPR54 and Its Cognate Ligand, KiSS-1
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This article is published in Endocrinology.The article was published on 2005-04-01 and is currently open access. It has received 60 citations till now.read more
Citations
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Journal ArticleDOI
Chronic perfluorooctanesulfonic acid exposure disrupts lipid metabolism in zebrafish
TL;DR: Evidence is provided that PFOS chronic exposure adversely impacts lipid metabolism in both F0 and F1 and the validity of using zebrafish as an alternative model forPFOS chronic toxicity screening is demonstrated.
Journal ArticleDOI
Follicle-Stimulating Hormone Responses to Kisspeptin in the Female Rat at the Preovulatory Period: Modulation by Estrogen and Progesterone Receptors
Juan Carlos Roa,E. Vigo,Juan M. Castellano,F Gaytan,David Garcia-Galiano,Víctor M. Navarro,Enrique Aguilar,F. A. Dijcks,A. G. H. Ederveen,Leonor Pinilla,P. I. van Noort,Manuel Tena-Sempere +11 more
TL;DR: A concurrent, indispensable role of ERalpha and PR is substantiated in the generation of FSH surges and the stimulation of F SH responses to kisspeptin at the ovulatory period and the data suggest that ERbeta might operate as a subtle, positive modulator of the preovulatory FSH responses tokisspeptin.
Book ChapterDOI
Chapter 3 The GnRH System and the Neuroendocrine Regulation of Reproduction
TL;DR: The identity and roles of these factors at the various stages of gonadal development are discussed in the chapter together with an examination of the manner in which the actions of sex steroids and the inhibitory neurotransmitter dopamine coordinate the activation of the GnRH–FSH/LH system during puberty and in relation to sexual maturation and spawning.
Journal ArticleDOI
Kisspeptin-10 stimulates the release of luteinizing hormone and testosterone in pre- and post-pubertal male goats.
TL;DR: The results show that the LH-releasing response to Kp10, as well as GnRH, is able to stimulate the release of T in male goats, and is greater in pre-pubertal than post- pubertal male goats.
Journal ArticleDOI
Effects of galanin-like peptide on luteinizing hormone secretion in the rat: sexually dimorphic responses and enhanced sensitivity at male puberty
Juan M. Castellano,Víctor M. Navarro,R. Fernández-Fernández,Juan Carlos Roa,E. Vigo,Rafael Pineda,Robert A. Steiner,Enrique Aguilar,Leonor Pinilla,Manuel Tena-Sempere +9 more
TL;DR: The ability of GALP to evoke LH secretion is sexually differentiated, with maximal responses at male puberty, a phenomenon which was not reverted by manipulation of sex steroid milieu during the critical neonatal period and was sensitive to metabolic stress.
References
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Journal ArticleDOI
The GPR54 gene as a regulator of puberty
Stephanie B. Seminara,Sophie Messager,Emmanouella E. Chatzidaki,Rosemary R. Thresher,James S. Acierno,Jenna K. Shagoury,Yousef Bo-Abbas,Wendy Kuohung,Kristine M. Schwinof,Alan G. Hendrick,Dirk Zahn,John Dixon,Ursula B. Kaiser,Susan A. Slaugenhaupt,James F. Gusella,Stephen O'Rahilly,Mark Carlton,William F. Crowley,Samuel Aparicio,William H. Colledge +19 more
TL;DR: Puberty is initiated when gonadotropin-releasing hormone begins to be secreted by the hypothalamus, and complementary genetic approaches in humans and mice identified genetic factors that determine the onset of puberty.
Journal ArticleDOI
Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54
Nicolas de Roux,Emmanuelle Génin,Jean Claude Carel,Fumihiko Matsuda,Chaussain Jl,Edwin Milgrom +5 more
TL;DR: The present study shows that loss of function of GPR54 is a cause of IHH, and it identifies GPR 54 and possibly KiSS1 protein-derived peptide as playing a major and previously unsuspected role in the physiology of the gonadotropic axis.
Journal ArticleDOI
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
Masato Kotani,Michel Detheux,Ann Vandenbogaerde,David Communi,Jean-Marie Vanderwinden,Emmanuel Le Poul,Stéphane Brézillon,Richard Tyldesley,Nathalie Suarez-Huerta,Fabrice Vandeput,Cédric Blanpain,Serge N. Schiffmann,Gilbert Vassart,Marc Parmentier +13 more
TL;DR: Stimulation of oxytocin secretion after kisspeptin administration to rats confirmed this hypothesis that human GPR54 was highly expressed in placenta, pituitary, pancreas, and spinal cord, suggesting a role in the regulation of endocrine function.
Journal ArticleDOI
Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.
Tetsuya Ohtaki,Yasushi Shintani,Susumu Honda,Hirokazu Matsumoto,Akira Hori,Kimiko Kanehashi,Yasuko Terao,Satoshi Kumano,Yoshihiro Takatsu,Yasushi Masuda,Yoshihiro Ishibashi,Takuya Watanabe,Mari Asada,Takao Yamada,Masato Suenaga,Chieko Kitada,Satoshi Usuki,Tsutomu Kurokawa,Haruo Onda,Osamu Nishimura,Masahiko Fujino +20 more
TL;DR: It is shown that KiSS-1 encodes a carboxy-terminally amidated peptide with 54 amino-acid residues, which is isolated from human placenta as the endogenous ligand of an orphan G-protein-coupled receptor (hOT7T175) and named ‘metastin’.
Journal ArticleDOI
A Role for Kisspeptins in the Regulation of Gonadotropin Secretion in the Mouse
Michelle L. Gottsch,Matthew Cunningham,Jeremy Troy Smith,Simina M. Popa,Blake V. Acohido,William F. Crowley,Stephanie B. Seminara,Donald K. Clifton,Robert A. Steiner +8 more
TL;DR: Kisspeptins are products of the KiSS-1 gene, which bind to a G protein-coupled receptor known as GPR54, and it is concluded that kisspeptin-GPR54 signaling may be part of the hypothalamus circuitry that governs the hypothalamic secretion of GnRH.
Related Papers (5)
Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor.
Tetsuya Ohtaki,Yasushi Shintani,Susumu Honda,Hirokazu Matsumoto,Akira Hori,Kimiko Kanehashi,Yasuko Terao,Satoshi Kumano,Yoshihiro Takatsu,Yasushi Masuda,Yoshihiro Ishibashi,Takuya Watanabe,Mari Asada,Takao Yamada,Masato Suenaga,Chieko Kitada,Satoshi Usuki,Tsutomu Kurokawa,Haruo Onda,Osamu Nishimura,Masahiko Fujino +20 more
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
The GPR54 gene as a regulator of puberty
Stephanie B. Seminara,Sophie Messager,Emmanouella E. Chatzidaki,Rosemary R. Thresher,James S. Acierno,Jenna K. Shagoury,Yousef Bo-Abbas,Wendy Kuohung,Kristine M. Schwinof,Alan G. Hendrick,Dirk Zahn,John Dixon,Ursula B. Kaiser,Susan A. Slaugenhaupt,James F. Gusella,Stephen O'Rahilly,Mark Carlton,William F. Crowley,Samuel Aparicio,William H. Colledge +19 more