New Gatekeepers of Reproduction: GPR54 and Its Cognate Ligand, KiSS-1
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This article is published in Endocrinology.The article was published on 2005-04-01 and is currently open access. It has received 60 citations till now.read more
Citations
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Journal ArticleDOI
Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of Puberty
Seong-Kyu Han,Michelle L. Gottsch,Kathy J Lee,Simina M. Popa,Jeremy Troy Smith,Sonya K Jakawich,Donald K. Clifton,Robert A. Steiner,Allan E. Herbison +8 more
TL;DR: It is demonstrated that kisspeptin exerts a potent depolarizing effect on the excitability of almost all adult GnRH neurons and that the responsiveness of Gn RH neurons tokisspeptin increases over postnatal development.
Journal ArticleDOI
Evidence for two distinct KiSS genes in non-placental vertebrates that encode kisspeptins with different gonadotropin-releasing activities in fish and mammals
Alicia Felip,Silvia Zanuy,Rafael Pineda,Leonor Pinilla,Manuel Carrillo,Manuel Tena-Sempere,Ana M. Gómez +6 more
TL;DR: The data are the first to provide conclusive evidence for the existence of a second KiSS gene, KiSS-2, in non-placental vertebrates, whose product is likely to play a dominant stimulatory role in the regulation of the gonadotropic axis at least in teleosts.
Journal ArticleDOI
Ontogeny and mechanisms of action for the stimulatory effect of kisspeptin on gonadotropin-releasing hormone system of the rat.
Juan M. Castellano,Víctor M. Navarro,R. Fernández-Fernández,Justo P. Castaño,María M. Malagón,Enrique Aguilar,Carlos Dieguez,Paolo Magni,Leonor Pinilla,Manuel Tena-Sempere +9 more
TL;DR: The present data document the ontogeny, sensitivity and intracellular signals for the stimulatory action of kisspeptin on the GnRH/LH axis in the rat and stress the essential role ofkisspeptin in normal, and eventually pathological, timing of puberty.
Journal ArticleDOI
Glucagon regulates hepatic kisspeptin to impair insulin secretion.
Woo Jin Song,Prosenjit Mondal,Andrew Wolfe,Laura C. Alonso,Rachel E. Stamateris,Benny W.T. Ong,Owen C. Lim,Kil S. Yang,Sally Radovick,Horacio J. Novaira,Emily Farber,Charles R. Farber,Stephen D. Turner,Mehboob A. Hussain +13 more
TL;DR: It is shown that glucagon stimulates via cAMP-PKA-CREB signaling hepatic production of the neuropeptide kisspeptin1, which acts on β cells to suppress GSIS, and this indicates a hormonal circuit between the liver and the endocrine pancreas in glycemia regulation and suggests in T2DM a sequential link between hyperglucagonemia via hepatic kisspe leptin1 to impaired insulin secretion.
Journal ArticleDOI
Hypothalamic Expression of KiSS-1 System and Gonadotropin-Releasing Effects of Kisspeptin in Different Reproductive States of the Female Rat
Juan Carlos Roa,E. Vigo,Juan M. Castellano,Víctor M. Navarro,R. Fernández-Fernández,Felipe F. Casanueva,Carlos Dieguez,Enrique Aguilar,Leonor Pinilla,Manuel Tena-Sempere +9 more
TL;DR: This work evaluated maximal LH and FSH secretory responses to kisspeptin-10, as well as changes in sensitivity and hypothalamic expression of KiSS-1 and GPR54 genes, in different physiological and experimental models in the adult female rat to document for the first time the changes in leptin expression and the gonadotropic effects in different functional states of the female reproductive axis.
References
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Journal ArticleDOI
KiSS-1, a Novel Human Malignant Melanoma Metastasis-Suppressor Gene
Jeong Hyung Lee,Mary E. Miele,Deana J. Hicks,Karen K. Phillips,Jeffery M. Trent,Bernard E. Weissman,Danny R. Welch +6 more
TL;DR: The results imply that mutations of genes on chromosome 6 are among those late genetic changes responsible for metastatic potential of malignant melanoma cells and suggest that KiSS-1 expression may be a useful marker for distinguishing metastatic melanoma from nonmetastatic melanomas.
Journal ArticleDOI
AXOR12, a Novel Human G Protein-coupled Receptor, Activated by the Peptide KiSS-1
Alison I. Muir,Larissa Chamberlain,Nabil Elshourbagy,David Michalovich,Darren J. Moore,Amy Calamari,Philip G. Szekeres,Henry M. Sarau,Jon K. Chambers,Paul R. Murdock,Klaudia Steplewski,Usman Shabon,Jane E. Miller,Susan E. Middleton,John G. Darker,Christopher Larminie,Shelagh Wilson,Derk J. Bergsma,Piers C. Emson,Richard L.M. Faull,Karen L. Philpott,David C. Harrison +21 more
TL;DR: High potency agonism was evident from peptides derived from the gene KiSS-1, the expression of which prevents metastasis in melanoma cells, and the nature of the putative cognate ligand for AXOR12 are discussed.
Journal ArticleDOI
Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male Rat
Michael S. Irwig,Gregory S. Fraley,Jeremy Troy Smith,Blake V. Acohido,Simina M. Popa,Matthew Cunningham,Michelle L. Gottsch,Donald K. Clifton,Robert A. Steiner +8 more
TL;DR: These results demonstrate that GnRH neurons are direct targets for regulation by kisspeptins and that KiSS-1 mRNA is regulated by gonadal hormones, suggesting that Ki SS-1 neurons play an important role in the feedback regulation of gonadotropin secretion.
Journal ArticleDOI
Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates.
Muhammad Shahab,Claudio A. Mastronardi,Stephanie B. Seminara,William F. Crowley,Sergio R. Ojeda,Tony M. Plant +5 more
TL;DR: Findings are consistent with the hypothesis that GPR54 signaling by its cognate ligand in the primate hypothalamus may be activated at the end of the juvenile phase of development and may contribute to the pubertal resurgence of pulsatile GnRH release, the central drive for puberty.
Journal ArticleDOI
Developmental and Hormonally Regulated Messenger Ribonucleic Acid Expression of KiSS-1 and Its Putative Receptor, GPR54, in Rat Hypothalamus and Potent Luteinizing Hormone-Releasing Activity of KiSS-1 Peptide
Víctor M. Navarro,Juan M. Castellano,R. Fernández-Fernández,M. L. Barreiro,Juan Carlos Roa,José E. Sánchez-Criado,Enrique Aguilar,Carlos Dieguez,Leonor Pinilla,Manuel Tena-Sempere +9 more
TL;DR: The current data support the contention that the hypothalamic KiSS-1/GPR54 system is a pivotal factor in central regulation of the gonadotropic axis at puberty and in adulthood.
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