Journal ArticleDOI
NLR activation takes a direct route
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TLDR
Understanding of NLR activation is updated in light of recent advances in nucleotide-binding domain and leucine-rich repeat containing research, with cellular imbalances and mitochondrial dysfunction being important.About:
This article is published in Trends in Biochemical Sciences.The article was published on 2013-03-01. It has received 37 citations till now. The article focuses on the topics: NLRX1 & NAIP.read more
Citations
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Journal ArticleDOI
The Therapeutic Potential of Modifying Inflammasomes and NOD-Like Receptors
TL;DR: The NOD-like receptors belong to the superfamily of pattern recognition receptors, a group of highly conserved molecules specialized in the recognition of invariant molecular patterns diffused across species.
Journal ArticleDOI
The Expanding Role of NLRs in Antiviral Immunity
TL;DR: Current knowledge pertaining to viruses and NLRs as well as areas of potential research, which will help advance the study of NLR biology during virus infection are discussed.
Journal ArticleDOI
The NBS-LRR architectures of plant R-proteins and metazoan NLRs evolved in independent events
TL;DR: This work uses phylogenetic reconstruction and tests of alternative evolutionary hypotheses combined with ancestral state reconstruction and an analysis of the phylogenetic distribution of the nucleotide binding site–leucine rich repeat (NBS-LRR) architecture to demonstrate that most likely, two distinct and separate evolutionary events gave rise to the NBS- LRR architecture in plant resistance proteins (R-proteins) and metazoan NOD-like receptors (NLRs).
Journal ArticleDOI
Biochemical and structural aspects of the ATP-binding domain in inflammasome-forming human NLRP proteins.
TL;DR: The functional and structural properties of the NACHT domain of a subfamily of NLRs, the NLRPs (NLR containing a pyrin domain), are detailed based on previous studies, sequence analysis, homology modeling, and structure predictions.
Journal ArticleDOI
IL-8 promotes HNSCC progression on CXCR1/2-meidated NOD1/RIP2 signaling pathway
Leong-Perng Chan,Ling-Feng Wang,Feng-Yu Chiang,Ka-Wo Lee,Po-Lin Kuo,Po-Lin Kuo,Chia-Hua Liang +6 more
TL;DR: IL-8 has an important role in HNSCC progression via a CXCR1/2-meidated NOD1/RIP2 signaling pathway and the blocking of IL-8 by siRNA reduces IL- 8, NOD 1 and RIP2 expressions in H NSCC cells, but not the level of NOD2.
References
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Journal ArticleDOI
Innate Immune Recognition
TL;DR: Microbial recognition by Toll-like receptors helps to direct adaptive immune responses to antigens derived from microbial pathogens to distinguish infectious nonself from noninfectious self.
Journal ArticleDOI
The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Taro Kawai,Shizuo Akira +1 more
TL;DR: Recent advances that have been made by research into the role of TLR biology in host defense and disease are described.
Journal ArticleDOI
A role for mitochondria in NLRP3 inflammasome activation
TL;DR: It is shown that mitophagy/autophagy blockade leads to the accumulation of damaged, ROS-generating mitochondria, and this in turn activates the NLRP3 inflammasome, and may explain the frequent association of mitochondrial damage with inflammatory diseases.
Journal ArticleDOI
Circulating mitochondrial DAMPs cause inflammatory responses to injury
Qin Zhang,Mustafa Raoof,Yu Chen,Yuka Sumi,Tolga Sursal,Wolfgang G. Junger,Karim Brohi,Kiyoshi Itagaki,Carl J. Hauser +8 more
TL;DR: It is shown that injury releases mitochondrial DAMPs into the circulation with functionally important immune consequences, including formyl peptides and mitochondrial DNA, which promote PMN Ca2+ flux and phosphorylation of mitogen-activated protein (MAP) kinases, thus leading to PMN migration and degranulation in vitro and in vivo.
Journal ArticleDOI
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
Kiichi Nakahira,Jeffrey A. Haspel,Jeffrey A. Haspel,Vijay A. K. Rathinam,Seon Jin Lee,Tamas Dolinay,Hilaire C. Lam,Joshua A. Englert,Marlene Rabinovitch,Manuela Cernadas,Hong Pyo Kim,Hong Pyo Kim,Katherine A. Fitzgerald,Stefan W. Ryter,Augustine M.K. Choi +14 more
TL;DR: This study suggests that autophagic proteins regulate NALP3-dependent inflammation by preserving mitochondria integrity and cytosolic translocation of mitochondrial DNA in response to lipopolysaccharide and ATP in macrophages.
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The NLR gene family: a standard nomenclature
Jenny P.-Y. Ting,Ruth C. Lovering,Emad S. Alnemri,John Bertin,Jeremy M. Boss,Beckley K. Davis,Richard A. Flavell,Stephen E. Girardin,Adam Godzik,Jonathan A. Harton,Hal M. Hoffman,Jean-Pierre Hugot,Naohiro Inohara,Alex MacKenzie,Lois J. Maltais,Gabriel Núñez,Yasunori Ogura,Luc A. Otten,Dana J. Philpott,John C. Reed,Walter Reith,Stefan Schreiber,Viktor Steimle,Peter A. Ward +23 more