Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses
Kiyohiro Takahasi,Mitsutoshi Yoneyama,Mitsutoshi Yoneyama,Tatsuya Nishihori,Reiko Hirai,Hiroyuki Kumeta,Ryo Narita,Michael Gale,Fuyuhiko Inagaki,Takashi Fujita +9 more
TLDR
It is suggested that the bipartite structure of CTD regulates RIG-I on encountering viral RNA patterns and CTD coincides with the autorepression domain.About:
This article is published in Molecular Cell.The article was published on 2008-02-29 and is currently open access. It has received 491 citations till now. The article focuses on the topics: DEAD Box Protein 58 & RNA-dependent RNA polymerase.read more
Citations
More filters
Journal ArticleDOI
Pattern Recognition Receptors and Inflammation
Osamu Takeuchi,Shizuo Akira +1 more
TL;DR: The role of PRRs, their signaling pathways, and how they control inflammatory responses are discussed.
Journal ArticleDOI
Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses
TL;DR: This review presents current knowledge on pathogen recognition through different families of PRRs and the increasingly complex signaling pathways responsible for activation of an inflammatory and antimicrobial response and medical implications are discussed.
Journal ArticleDOI
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling.
Hiroki Ishikawa,Glen N. Barber +1 more
TL;DR: The identification of a molecule (STING; stimulator of interferon genes) that appears essential for effective innate immune signalling processes is reported, implying a potential role for the translocon in innate signalling pathways activated by select viruses as well as intracellular DNA.
Journal ArticleDOI
The roles of TLRs, RLRs and NLRs in pathogen recognition
Taro Kawai,Shizuo Akira +1 more
TL;DR: Recent insights into pathogen sensing by PRRs are summarized and specific signaling pathways that lead to expression of genes that tailor immune responses to particular microbes are summarized.
Journal ArticleDOI
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling (Nature (2008) 455, (674-678))
Hiroki Ishikawa,Glen N. Barber +1 more
TL;DR: This corrects the article to show that the H2O2/H2O/O2 mixture is dominated by the H3O/ O2 mixture, rather than the O2/O3 mixture, which is more commonly associated with H2Os.
References
More filters
Journal ArticleDOI
NMRPipe: a multidimensional spectral processing system based on UNIX pipes
TL;DR: The asynchronous pipeline scheme provides other substantial advantages, including high flexibility, favorable processing speeds, choice of both all-in-memory and disk-bound processing, easy adaptation to different data formats, simpler software development and maintenance, and the ability to distribute processing tasks on multi-CPU computers and computer networks.
Journal ArticleDOI
Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
Journal ArticleDOI
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.
TL;DR: It is shown that mammalian TLR3 recognizes dsRNA, and that activation of the receptor induces the activation of NF-κB and the production of type I interferons (IFNs).
Journal ArticleDOI
AQUA and PROCHECK-NMR: programs for checking the quality of protein structures solved by NMR
TL;DR: The AQUA and PROCHECK-NMR programs provide a means of validating the geometry and restraint violations of an ensemble of protein structures solved by solution NMR, and their outputs include a detailed breakdown of the restraint violations.
Journal ArticleDOI
Protein structure comparison by alignment of distance matrices
Liisa Holm,Chris Sander +1 more
TL;DR: A novel algorithm (DALI) for optimal pairwise alignment of protein structures that identifies structural resemblances and common structural cores accurately and sensitively, even in the presence of geometrical distortions is developed.