Journal ArticleDOI
Object recognition test in mice
Marianne Leger,Anne Quiedeville,Valentine Bouet,Benoit Haelewyn,Michel Boulouard,Pascale Schumann-Bard,Thomas Freret +6 more
TLDR
This protocol reduces inter-individual variability with the use of a selection criterion based on a minimal time of exploration for both objects during each session, and describes the three most commonly used variants, containing long (3 d), short (1 d) or no habituation phases.Abstract:
The object recognition test is now among the most commonly used behavioral tests for mice. A mouse is presented with two similar objects during the first session, and then one of the two objects is replaced by a new object during a second session. The amount of time taken to explore the new object provides an index of recognition memory. As more groups have used the protocol, the variability of the procedures used in the object recognition test has increased steadily. This protocol provides a necessary standardization of the procedure. This protocol reduces inter-individual variability with the use of a selection criterion based on a minimal time of exploration for both objects during each session. In this protocol, we describe the three most commonly used variants, containing long (3 d), short (1 d) or no habituation phases. Thus, with a short intersession interval (e.g., 6 h), this procedure can be performed in 4, 2 or 1 d, respectively, according to the duration of the habituation phase. This protocol should allow for the comparison of results from different studies, while permitting adaption of the protocol to the constraints of the experimenter.read more
Citations
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Multisensory stimulation improves cognition and behavior in adult male rats born to LT4-treated thyroidectomized dams.
Alice Batistuzzo,Guilherme G de Almeida,Tayna S Brás,Victoria P Zucato,Alexandre J T Arnold,Gisele Giannocco,Juliana M Sato,Laís M Yamanouchi,Eduardo Dias Junior,Fernanda Beraldo Lorena,Bruna Pascarelli Pedrico do Nascimento,Antonio C. Bianco,Miriam O. Ribeiro +12 more
TL;DR: C cognition and mood impairments caused by moderate gestational hypothyroidism were reversed or minimized in rats through MS, and MS restored short-term memory and anxiety while improving depressive like-behaviors.
Journal ArticleDOI
Age-Dependent Cellular and Behavioral Deficits Induced by Molecularly Targeted Drugs Are Reversible.
TL;DR: Analysis of rapidly developing brain structures important for sensorimotor and cognitive function showed that earlier neonatal administration of targeted therapies attenuated white matter oligodendroglia and hippocampal neuronal development more profoundly than later administration, leading to long-lasting behavioral deficits.
Journal ArticleDOI
Impairment to Cognitive Functions in Wistar Rats in a Model of the Preclinical Stage of Parkinson’s Disease
TL;DR: Administration of lactacystin was found to degrade spatial memory, episodic memory, and recognition of novel objects in rats on the background of a transient increase in the level of anxiety, suggesting that impairments in the cognitive and affective domains may be early signs of the development of neurodegeneration in the brain.
Journal ArticleDOI
Alteration in peritoneal cells with the chemokine CX3CL1 reverses age-associated impairment of recognition memory
Yoshinori Takei,Yoko Amagase,Keiko Iida,Tomohiro Sagawa,Ai Goto,Ryuichi Kambayashi,Hiroko Izumi-Nakaseko,Akio Matsumoto,S. Kawai,Atsushi Sugiyama,Tatsuyuki Takada,Akira Hirasawa +11 more
TL;DR: In this article , CX3CL1 was administered into the peritoneal cavity of aged mice to investigate its impact on the aging process, which not only reversed the age-associated accumulation of cells expressing the senescence marker p16INK4a but also increased peritoneic phagocytic activity.
Journal ArticleDOI
Protective Effects of Fish (Alaska Pollock) Protein Intake against Short-Term Memory Decline in Senescence-Accelerated Mice
Yuki Murakami,Ryota Hosomi,Ayano Nishimoto,Toshimasa Nishiyama,Munehiro Yoshida,Kenji Fukunaga +5 more
TL;DR: In this article , the effects of FO and FP on brain function were investigated in senescence-accelerated mouse-prone 10 (SAMP10) mice, and the results suggest that FP intake prevents age-related cognitive dysfunction by maintaining axonal morphology in the Hipp of SAMP10 mice.
References
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Journal ArticleDOI
A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data.
TL;DR: A new memory test in rats, based on the differential exploration of familiar and new objects, which is comparable to memory tests currently used in man and allows interspecies comparisons.
Journal ArticleDOI
The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
Alicia A. Walf,Cheryl A. Frye +1 more
TL;DR: The elevated plus maze is a widely used behavioral assay for rodents and it has been validated to assess the anti-anxiety effects of pharmacological agents and steroid hormones, and to define brain regions and mechanisms underlying anxiety-related behavior.
Journal ArticleDOI
Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'
Rick A. Bevins,Joyce Besheer +1 more
TL;DR: The object-recognition task has been used to study mutant mice, aging deficits, early developmental influences, nootropic manipulations, teratological drug exposure and novelty seeking.
Journal ArticleDOI
When is the hippocampus involved in recognition memory
TL;DR: The hippocampus plays a role in recognition memory when such memory involves remembering that a particular stimulus occurred in a particular place or when the memory contains a temporal or object recency component.