Journal ArticleDOI
Object recognition test in mice
Marianne Leger,Anne Quiedeville,Valentine Bouet,Benoit Haelewyn,Michel Boulouard,Pascale Schumann-Bard,Thomas Freret +6 more
TLDR
This protocol reduces inter-individual variability with the use of a selection criterion based on a minimal time of exploration for both objects during each session, and describes the three most commonly used variants, containing long (3 d), short (1 d) or no habituation phases.Abstract:
The object recognition test is now among the most commonly used behavioral tests for mice. A mouse is presented with two similar objects during the first session, and then one of the two objects is replaced by a new object during a second session. The amount of time taken to explore the new object provides an index of recognition memory. As more groups have used the protocol, the variability of the procedures used in the object recognition test has increased steadily. This protocol provides a necessary standardization of the procedure. This protocol reduces inter-individual variability with the use of a selection criterion based on a minimal time of exploration for both objects during each session. In this protocol, we describe the three most commonly used variants, containing long (3 d), short (1 d) or no habituation phases. Thus, with a short intersession interval (e.g., 6 h), this procedure can be performed in 4, 2 or 1 d, respectively, according to the duration of the habituation phase. This protocol should allow for the comparison of results from different studies, while permitting adaption of the protocol to the constraints of the experimenter.read more
Citations
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Challenged Immune System Improves Cognitive-Behavioral Responses In Homeostasis And Recovers Malaria-Induced Cognitive Impairment In Mice
TL;DR: It is shown that the immune modulation induced by a specific combination of immune stimuli can improve the long-term memory of healthy adult mice and prevent the negative cognitive-behavioural impairments caused by a single episode of mild Plasmodium berghei ANKA malaria.
Journal ArticleDOI
High fat diet exacerbates long-term metabolic, neuropathological, and behavioral derangements in an experimental mouse model of traumatic brain injury.
Stanley Ibeh,Nour-Mounira Z. Bakkar,Fatimah Ahmad,Judith Nwaiwu,Chloe Barsa,Sarin Mekhjian,Mohammad Amine Reslan,Ali H. Eid,Hayat Harati,Sanaa Nabha,Yehia Mechref,Ahmed F. El-Yazbi,Firas Kobeissy +12 more
TL;DR: In this paper , an experimental mouse model of open head injury, induced by the controlled cortical impact was used along with high-fat feeding to evaluate the impact of HFD on brain injury outcomes.
Journal ArticleDOI
Motopsin deficiency imparts partial insensitivity to doxorubicin-induced hippocampal impairments in adult mice.
TL;DR: In this paper, the role of motopsin in the neuropathological development of cognitive impairments following chemotherapy, also known as chemobrain, was evaluated for open field, novel object recognition, and passive avoidance tests.
Posted ContentDOI
Constitutive AP2gamma deficiency reduces postnatal hippocampal neurogenesis and induces behavioral deficits in juvenile mice that persist during adulthood
Eduardo Loureiro-Campos,N.D. Alves,A. Mateus-Pinheiro,Patrícia Patrício,Carina Soares-Cunha,Joana Silva,Vanessa Morais Sardinha,Bárbara Mendes-Pinheiro,Tiago Silveira-Rosa,Ana João Rodrigues,João Filipe Oliveira,João Filipe Oliveira,Nuno Sousa,Luísa Pinto +13 more
TL;DR: In this article, the authors explored the neurogenic, behavioral, and functional impact of a constitutive AP2{gamma} heterozygous deletion in mice from early postnatal development until adulthood.
Journal ArticleDOI
Capacitive Electrode-Based Electric Field Treatments on Redox-Toxic Iron Deposits in Transgenic AD Mouse Models: The Electroceutical Targeting of Alzheimer’s Disease Feasibility Study
Younshick Choi,W. Lee,Jaemeun Lee,Sun Hyun Park,Sun-Woong Kim,Kihong Kim,Su-Myung Park,Eun Ho Kim,Jong-Ki Kim +8 more
TL;DR: In this article , a capacitive electrode-based alternating electric field (AEF) was applied to a suspension of magnetite (Fe3O4) to measure field-sensitized reactive oxygen species (ROS) generation.
References
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Journal ArticleDOI
A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data.
TL;DR: A new memory test in rats, based on the differential exploration of familiar and new objects, which is comparable to memory tests currently used in man and allows interspecies comparisons.
Journal ArticleDOI
The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
Alicia A. Walf,Cheryl A. Frye +1 more
TL;DR: The elevated plus maze is a widely used behavioral assay for rodents and it has been validated to assess the anti-anxiety effects of pharmacological agents and steroid hormones, and to define brain regions and mechanisms underlying anxiety-related behavior.
Journal ArticleDOI
Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'
Rick A. Bevins,Joyce Besheer +1 more
TL;DR: The object-recognition task has been used to study mutant mice, aging deficits, early developmental influences, nootropic manipulations, teratological drug exposure and novelty seeking.
Journal ArticleDOI
When is the hippocampus involved in recognition memory
TL;DR: The hippocampus plays a role in recognition memory when such memory involves remembering that a particular stimulus occurred in a particular place or when the memory contains a temporal or object recency component.