Journal ArticleDOI
Object recognition test in mice
Marianne Leger,Anne Quiedeville,Valentine Bouet,Benoit Haelewyn,Michel Boulouard,Pascale Schumann-Bard,Thomas Freret +6 more
TLDR
This protocol reduces inter-individual variability with the use of a selection criterion based on a minimal time of exploration for both objects during each session, and describes the three most commonly used variants, containing long (3 d), short (1 d) or no habituation phases.Abstract:
The object recognition test is now among the most commonly used behavioral tests for mice. A mouse is presented with two similar objects during the first session, and then one of the two objects is replaced by a new object during a second session. The amount of time taken to explore the new object provides an index of recognition memory. As more groups have used the protocol, the variability of the procedures used in the object recognition test has increased steadily. This protocol provides a necessary standardization of the procedure. This protocol reduces inter-individual variability with the use of a selection criterion based on a minimal time of exploration for both objects during each session. In this protocol, we describe the three most commonly used variants, containing long (3 d), short (1 d) or no habituation phases. Thus, with a short intersession interval (e.g., 6 h), this procedure can be performed in 4, 2 or 1 d, respectively, according to the duration of the habituation phase. This protocol should allow for the comparison of results from different studies, while permitting adaption of the protocol to the constraints of the experimenter.read more
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OUP accepted manuscript
TL;DR: The imprinting patterns and functions of RTL1 in the brain have not been well-investigated as discussed by the authors , and it was found that Rtl1 was paternally, but not maternally expressed in brain stem, thalamus, and hypothalamus of mice, and imprinting status was maintained in human brain.
Journal ArticleDOI
Assessment of Antidepressant-like, Anxiolytic Effects and Impact on Memory of Pimpinella anisum L. Total Extract on Swiss Albino Mice.
Imane Es-Safi,Hamza Mechchate,Amal Amaghnouje,Amine Elbouzidi,Mohamed Bouhrim,Noureddine Bencheikh,Christophe Hano,Dalila Bousta +7 more
TL;DR: In this article, the authors investigated the effect of Pimpinella anisum (PATE) extract on depression and anxiety using the Forced Swimming Test (FST), Tail Suspension Test (TST), Open Field Test (OFT), and Light-Dark Box Test (LDBT) on Swiss albino mice.
Journal ArticleDOI
Neuroprotective Effects of Fluoxetine on Molecular Markers of Circadian Rhythm, Cognitive Deficits, Oxidative Damage, and Biomarkers of Alzheimer's Disease-Like Pathology Induced under Chronic Constant Light Regime in Wistar Rats.
TL;DR: In this article, the authors showed that chronic constant light exposure might contribute significantly to development of AD-like-phenotype in rats and that fluoxetine (Flx) treatment might protect the brain against it.
Journal ArticleDOI
Microglia-specific deletion of histone deacetylase 3 promotes inflammation resolution, white matter integrity, and functional recovery in a mouse model of traumatic brain injury
Yongfang Zhao,Hongfeng Mu,Yichen Huang,Sicheng Li,Yangfan Wang,R. Anne Stetler,Michael V. L. Bennett,C. Edward Dixon,Jun Chen,Yejie Shi +9 more
TL;DR: In this paper , microglia-specific HDAC3 knockout (HDAC3 miKO) was induced in CX3CR1 CreER mice with 5 days of tamoxifen treatment followed by a 30-day development interval.
Journal ArticleDOI
Microglia-specific deletion of histone deacetylase 3 promotes inflammation resolution, white matter integrity, and functional recovery in a mouse model of traumatic brain injury
Yong-Jie Zhao,Hongfeng Mu,Yichen Huang,Sicheng Li,Yangfan Wang,R. Anne Stetler,Michael V. L. Bennett,C. Edward Dixon,Jun Chen,Yejie Shi +9 more
TL;DR: In this article , microglia-specific HDAC3 knockout (HDAC3 miKO) was induced in CX3CR1 CreER mice with 5 days of tamoxifen treatment followed by a 30-day development interval.
References
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Journal ArticleDOI
A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data.
TL;DR: A new memory test in rats, based on the differential exploration of familiar and new objects, which is comparable to memory tests currently used in man and allows interspecies comparisons.
Journal ArticleDOI
The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
Alicia A. Walf,Cheryl A. Frye +1 more
TL;DR: The elevated plus maze is a widely used behavioral assay for rodents and it has been validated to assess the anti-anxiety effects of pharmacological agents and steroid hormones, and to define brain regions and mechanisms underlying anxiety-related behavior.
Journal ArticleDOI
Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'
Rick A. Bevins,Joyce Besheer +1 more
TL;DR: The object-recognition task has been used to study mutant mice, aging deficits, early developmental influences, nootropic manipulations, teratological drug exposure and novelty seeking.
Journal ArticleDOI
When is the hippocampus involved in recognition memory
TL;DR: The hippocampus plays a role in recognition memory when such memory involves remembering that a particular stimulus occurred in a particular place or when the memory contains a temporal or object recency component.