Journal ArticleDOI
Object recognition test in mice
Marianne Leger,Anne Quiedeville,Valentine Bouet,Benoit Haelewyn,Michel Boulouard,Pascale Schumann-Bard,Thomas Freret +6 more
TLDR
This protocol reduces inter-individual variability with the use of a selection criterion based on a minimal time of exploration for both objects during each session, and describes the three most commonly used variants, containing long (3 d), short (1 d) or no habituation phases.Abstract:
The object recognition test is now among the most commonly used behavioral tests for mice. A mouse is presented with two similar objects during the first session, and then one of the two objects is replaced by a new object during a second session. The amount of time taken to explore the new object provides an index of recognition memory. As more groups have used the protocol, the variability of the procedures used in the object recognition test has increased steadily. This protocol provides a necessary standardization of the procedure. This protocol reduces inter-individual variability with the use of a selection criterion based on a minimal time of exploration for both objects during each session. In this protocol, we describe the three most commonly used variants, containing long (3 d), short (1 d) or no habituation phases. Thus, with a short intersession interval (e.g., 6 h), this procedure can be performed in 4, 2 or 1 d, respectively, according to the duration of the habituation phase. This protocol should allow for the comparison of results from different studies, while permitting adaption of the protocol to the constraints of the experimenter.read more
Citations
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Acetylcholine deficiency disrupts extratelencephalic projection neurons in the prefrontal cortex in a mouse model of Alzheimer’s disease
Qingtao Sun,Jianping Zhang,Anan Li,Mei Yao,Guangcai Liu,Siqi Chen,Yue Luo,Zhi Wang,Hui Gong,Xiangning Li,Qingming Luo +10 more
TL;DR: In this paper , the authors used fiber photometry and optogenetics to find that reduced neural activity in extratelencephalic projection neurons in the medial prefrontal cortex (mPFC) of 5×FAD mice led to object recognition memory (ORM) deficits.
Journal ArticleDOI
SARS-CoV-2 spike protein induces cognitive deficit and anxiety-like behavior in mouse via non-cell autonomous hippocampal neuronal death
TL;DR: In this article , the authors explored the possibility that the brain-infiltrating SARS-CoV-2 spike protein contributes to the development of neurological symptoms observed in COVID-19 patients.
Journal ArticleDOI
A diet enriched with plant sterols prevents the memory impairment induced by cholesterol loss in senescence-accelerated mice
Azucena Pérez-Cañamás,Sara Sarroca,Carolina Melero-Jerez,David Porquet,Joan Sansa,Shira Knafo,Shira Knafo,Shira Knafo,José A. Esteban,Coral Sanfeliu,Maria Dolores Ledesma +10 more
TL;DR: Plant sterol (PSE)-enriched diet prevents long-term potentiation impairment and cognitive deficits in SAMP8 mice without altering cholesterol levels, and suggests that PSE overtake cholesterol functions in the brain contributing to reduce deleterious consequences of cholesterol loss during aging.
Journal ArticleDOI
Defective memory engram reactivation underlies impaired fear memory recall in Fragile X syndrome
TL;DR: It is shown that the efficacy of hippocampal engram reactivation is reduced in Fmr1 KO mice performing contextual fear memory recall, and enriched environment may rescue cognitive deficits by improving network activation accuracy.
Journal ArticleDOI
Trichostatin A ameliorates Alzheimer's disease-related pathology and cognitive deficits by increasing albumin expression and Aβ clearance in APP/PS1 mice.
Qiang Su,Tian Li,He Peifeng,Lu Xuechun,Yu Qi,Qi-Chao Gao,Zhao-Jun Wang,Mei-Na Wu,Dan Yang,Jin-Shun Qi +9 more
TL;DR: Zhang et al. as mentioned in this paper examined the anti-AD effects of Trichostatin A (TSA), particularly investigating its underlying cellular and molecular mechanisms, and suggested TSA as a novel promising candidate for the AD treatment.
References
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Journal ArticleDOI
A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data.
TL;DR: A new memory test in rats, based on the differential exploration of familiar and new objects, which is comparable to memory tests currently used in man and allows interspecies comparisons.
Journal ArticleDOI
The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
Alicia A. Walf,Cheryl A. Frye +1 more
TL;DR: The elevated plus maze is a widely used behavioral assay for rodents and it has been validated to assess the anti-anxiety effects of pharmacological agents and steroid hormones, and to define brain regions and mechanisms underlying anxiety-related behavior.
Journal ArticleDOI
Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'
Rick A. Bevins,Joyce Besheer +1 more
TL;DR: The object-recognition task has been used to study mutant mice, aging deficits, early developmental influences, nootropic manipulations, teratological drug exposure and novelty seeking.
Journal ArticleDOI
When is the hippocampus involved in recognition memory
TL;DR: The hippocampus plays a role in recognition memory when such memory involves remembering that a particular stimulus occurred in a particular place or when the memory contains a temporal or object recency component.