Journal ArticleDOI
Object recognition test in mice
Marianne Leger,Anne Quiedeville,Valentine Bouet,Benoit Haelewyn,Michel Boulouard,Pascale Schumann-Bard,Thomas Freret +6 more
TLDR
This protocol reduces inter-individual variability with the use of a selection criterion based on a minimal time of exploration for both objects during each session, and describes the three most commonly used variants, containing long (3 d), short (1 d) or no habituation phases.Abstract:
The object recognition test is now among the most commonly used behavioral tests for mice. A mouse is presented with two similar objects during the first session, and then one of the two objects is replaced by a new object during a second session. The amount of time taken to explore the new object provides an index of recognition memory. As more groups have used the protocol, the variability of the procedures used in the object recognition test has increased steadily. This protocol provides a necessary standardization of the procedure. This protocol reduces inter-individual variability with the use of a selection criterion based on a minimal time of exploration for both objects during each session. In this protocol, we describe the three most commonly used variants, containing long (3 d), short (1 d) or no habituation phases. Thus, with a short intersession interval (e.g., 6 h), this procedure can be performed in 4, 2 or 1 d, respectively, according to the duration of the habituation phase. This protocol should allow for the comparison of results from different studies, while permitting adaption of the protocol to the constraints of the experimenter.read more
Citations
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Night Photostimulation of Clearance of Beta-Amyloid from Mouse Brain: New Strategies in Preventing Alzheimer’s Disease
Oxana Semyachkina-Glushkovskaya,Thomas Penzel,Inna Blokhina,Alexander Khorovodov,Ivan V. Fedosov,Tingting Yu,Georgy Karandin,Arina Evsukova,Dariya Elovenko,Viktoria Adushkina,Alexander Shirokov,Alexander Dubrovskii,Andrey Terskov,Nikita A. Navolokin,Maria Tzoy,Vasily Ageev,Ilana Agranovich,Valeria Telnova,Anna Tsven,Jürgen Kurths +19 more
TL;DR: This paper showed that Transcranial photostimulation (PS) at night improves memory and reduces Aβ accumulation in the brain of AD mice more effectively than PS during the day.
Journal ArticleDOI
Licorice extract attenuates brain aging of D-galactose induced rats through inhibition of oxidative stress and attenuation of neuronal apoptosis
TL;DR: The findings indicate that the licorice extract effectively attenuated cognitive damage, improved oxidative stress and apoptosis in aging rats induced by D-gal, and played a significant role in antioxidation and anti-neuronal apoptosis.
Journal ArticleDOI
Mitochondrial ubiquitin ligase alleviates Alzheimer's disease pathology via blocking the toxic amyloid-β oligomer generation.
Keisuke Takeda,Aoi Uda,Mikihiro Mitsubori,Shun Nagashima,Hiroko Iwasaki,Naoki Ito,Naoki Ito,Isshin Shiiba,Isshin Shiiba,Satoshi Ishido,Masaaki Matsuoka,Ryoko Inatome,Ryoko Inatome,Shigeru Yanagi,Shigeru Yanagi +14 more
TL;DR: In this paper, the perturbation of mitochondrial dynamics by MITOL deletion triggers mitochondrial impairments and exacerbates cognitive decline in a mouse model with AD-related Aβ pathology.
Journal ArticleDOI
S100A9 Upregulation Contributes to Learning and Memory Impairments by Promoting Microglia M1 Polarization in Sepsis Survivor Mice.
Yan-Ling Liao,Yan-Ling Liao,Xiao-Yan Zhou,Mu-Huo Ji,Liangcheng Qiu,Xiaohui Chen,Cansheng Gong,Ying Lin,Yan-hua Guo,Jian-Jun Yang,Jian-Jun Yang +10 more
TL;DR: This study suggests that S 100A9 upregulation might contribute to learning and memory impairments by promoting microglia M1 polarization in sepsis survivors, whereas S100A9 inhibition might provide a potential therapeutic target for SAE.
Journal ArticleDOI
Aerobic Physical Exercise as a Neuroprotector Strategy for Ethanol Binge-Drinking Effects in the Hippocampus and Systemic Redox Status in Rats
Dinair Pamplona-Santos,Kátia Lamarão-Vieira,Priscila Cunha Nascimento,Leonardo Oliveira Bittencourt,Márcio Gonçalves Corrêa,Sávio Monteiro dos Santos,Sabrina C. Cartágenes,Luanna Melo Pereira Fernandes,Marta Chagas Monteiro,Cristiane Socorro Ferraz Maia,Rafael Rodrigues Lima +10 more
TL;DR: The results showed that EtOH caused marked oxidative stress and mnemonic damage, and the physical exercise promoted neuroprotective effects, among them, the modulation of oxidative biochemistry in plasma and in the hippocampus and by reducing LPO levels and increasing antioxidant parameters and cognitive function improvement.
References
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Journal ArticleDOI
A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data.
TL;DR: A new memory test in rats, based on the differential exploration of familiar and new objects, which is comparable to memory tests currently used in man and allows interspecies comparisons.
Journal ArticleDOI
The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
Alicia A. Walf,Cheryl A. Frye +1 more
TL;DR: The elevated plus maze is a widely used behavioral assay for rodents and it has been validated to assess the anti-anxiety effects of pharmacological agents and steroid hormones, and to define brain regions and mechanisms underlying anxiety-related behavior.
Journal ArticleDOI
Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'
Rick A. Bevins,Joyce Besheer +1 more
TL;DR: The object-recognition task has been used to study mutant mice, aging deficits, early developmental influences, nootropic manipulations, teratological drug exposure and novelty seeking.
Journal ArticleDOI
When is the hippocampus involved in recognition memory
TL;DR: The hippocampus plays a role in recognition memory when such memory involves remembering that a particular stimulus occurred in a particular place or when the memory contains a temporal or object recency component.