Journal ArticleDOI
Object recognition test in mice
Marianne Leger,Anne Quiedeville,Valentine Bouet,Benoit Haelewyn,Michel Boulouard,Pascale Schumann-Bard,Thomas Freret +6 more
TLDR
This protocol reduces inter-individual variability with the use of a selection criterion based on a minimal time of exploration for both objects during each session, and describes the three most commonly used variants, containing long (3 d), short (1 d) or no habituation phases.Abstract:
The object recognition test is now among the most commonly used behavioral tests for mice. A mouse is presented with two similar objects during the first session, and then one of the two objects is replaced by a new object during a second session. The amount of time taken to explore the new object provides an index of recognition memory. As more groups have used the protocol, the variability of the procedures used in the object recognition test has increased steadily. This protocol provides a necessary standardization of the procedure. This protocol reduces inter-individual variability with the use of a selection criterion based on a minimal time of exploration for both objects during each session. In this protocol, we describe the three most commonly used variants, containing long (3 d), short (1 d) or no habituation phases. Thus, with a short intersession interval (e.g., 6 h), this procedure can be performed in 4, 2 or 1 d, respectively, according to the duration of the habituation phase. This protocol should allow for the comparison of results from different studies, while permitting adaption of the protocol to the constraints of the experimenter.read more
Citations
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Supramammillary nucleus synchronizes with dentate gyrus to regulate spatial memory retrieval through glutamate release.
Ya-Dong Li,Hechen Bao,Yan-Jia Luo,Cherasse Yoan,Heather A. Sullivan,Luis Quintanilla,Ian R. Wickersham,Michael Lazarus,Yen-Yu Ian Shih,Juan Song +9 more
TL;DR: It is reported that SuM-DG Ca2+ activities are highly correlated during spatial memory retrieval as compared to the moderate correlation during memory encoding when mice are performing a location discrimination task.
Journal ArticleDOI
Angiotensin receptor (AT2R) agonist C21 prevents cognitive decline after permanent stroke in aged animals-A randomized double- blind pre-clinical study.
Heba A. Ahmed,Tauheed Ishrat,Bindu Pillai,Kristopher M. Bunting,Almira Vazdarjanova,Jennifer L. Waller,Adviye Ergul,Susan C. Fagan,Susan C. Fagan +8 more
TL;DR: It is demonstrated that the angiotensin receptor (AT2R) agonist C21 effectively prevents the development of PSCI in aged animals.
Journal ArticleDOI
Cognitive impairment in the WAG/Rij rat absence model is secondary to absence seizures and depressive-like behavior.
Antonio Leo,Rita Citraro,Martina Tallarico,Michelangelo Iannone,Ekaterina Fedosova,Valentina Nesci,Giovambattista De Sarro,Karine Sarkisova,Emilio Russo +8 more
TL;DR: It seems that cognitive impairment in this strain, similarly to depressive-like behavior, is secondary to the occurrence of absence seizures, which might be necessary for the expression of cognitive impairment, and results suggest an age-dependent impairment of cognitive performance in WAG/Rij rats, which could be linked to the age- dependent increase of spike wave discharges.
Journal ArticleDOI
Role of angiotensin system modulation on progression of cognitive impairment and brain MRI changes in aged hypertensive animals - A randomized double- blind pre-clinical study.
Heba A. Ahmed,Tauheed Ishrat,Bindu Pillai,Kristopher M. Bunting,Ashni Patel,Almira Vazdarjanova,Jennifer L. Waller,Ali S. Arbab,Adviye Ergul,Susan C. Fagan,Susan C. Fagan +10 more
TL;DR: It is demonstrated that delayed administration of RAS modulators effectively preserve cognitive function and prevent the development / progression of VCI in aged hypertensive animals with chronic cerebral hypoperfusion.
Journal ArticleDOI
Increased Synthesis of Chondroitin Sulfate Proteoglycan Promotes Adult Hippocampal Neurogenesis in Response to Enriched Environment.
TL;DR: Findings indicate that CSPG underlies adult hippocampal neurogenesis and suggest that increased synthesis of C SPG may mediate promotion of granule cell production in response to EE.
References
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Journal ArticleDOI
A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data.
TL;DR: A new memory test in rats, based on the differential exploration of familiar and new objects, which is comparable to memory tests currently used in man and allows interspecies comparisons.
Journal ArticleDOI
The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
Alicia A. Walf,Cheryl A. Frye +1 more
TL;DR: The elevated plus maze is a widely used behavioral assay for rodents and it has been validated to assess the anti-anxiety effects of pharmacological agents and steroid hormones, and to define brain regions and mechanisms underlying anxiety-related behavior.
Journal ArticleDOI
Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'
Rick A. Bevins,Joyce Besheer +1 more
TL;DR: The object-recognition task has been used to study mutant mice, aging deficits, early developmental influences, nootropic manipulations, teratological drug exposure and novelty seeking.
Journal ArticleDOI
When is the hippocampus involved in recognition memory
TL;DR: The hippocampus plays a role in recognition memory when such memory involves remembering that a particular stimulus occurred in a particular place or when the memory contains a temporal or object recency component.