Journal ArticleDOI
Object recognition test in mice
Marianne Leger,Anne Quiedeville,Valentine Bouet,Benoit Haelewyn,Michel Boulouard,Pascale Schumann-Bard,Thomas Freret +6 more
TLDR
This protocol reduces inter-individual variability with the use of a selection criterion based on a minimal time of exploration for both objects during each session, and describes the three most commonly used variants, containing long (3 d), short (1 d) or no habituation phases.Abstract:
The object recognition test is now among the most commonly used behavioral tests for mice. A mouse is presented with two similar objects during the first session, and then one of the two objects is replaced by a new object during a second session. The amount of time taken to explore the new object provides an index of recognition memory. As more groups have used the protocol, the variability of the procedures used in the object recognition test has increased steadily. This protocol provides a necessary standardization of the procedure. This protocol reduces inter-individual variability with the use of a selection criterion based on a minimal time of exploration for both objects during each session. In this protocol, we describe the three most commonly used variants, containing long (3 d), short (1 d) or no habituation phases. Thus, with a short intersession interval (e.g., 6 h), this procedure can be performed in 4, 2 or 1 d, respectively, according to the duration of the habituation phase. This protocol should allow for the comparison of results from different studies, while permitting adaption of the protocol to the constraints of the experimenter.read more
Citations
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The Deleterious Effects of Mobile Phone Radiation (900 Mhz) on Behavior Profile of Mice: The Effect of Alternative Therapy in Neuroprotection
TL;DR: Housing under pyramidal architectural shape may have a positive effect on cognition and spatial memory impairment induced by the hazard of electromagnetic waves and this study can be useful for architects and advised to be used in the creation of healthy architecture buildings for either human or animal farms.
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Natural forgetting is modulated by experience
TL;DR: In this paper , the authors examined whether forgetting is governed by changes in engram plasticity and suggest that it helps animals prioritize relevant memory representations for adaptive behavior, which can be explained by a computational model in which engrams that are subjectively less relevant for adaptive behaviour are more likely to be forgotten.
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Transmembrane protein 184B (TMEM184B) promotes expression of synaptic gene networks in the mouse hippocampus
TL;DR: The data suggest that TMEM184B is required for proper synaptic gene expression and function but may not be causal for AD and related dementias.
Journal ArticleDOI
P2X7 receptor contributes to long-term neuroinflammation and cognitive impairment in sepsis-surviving mice
Vinícius Santos Alves,Joyce P. da Silva,Fabiana Cristina Rodrigues,Suzana B. Araújo,André Luiz Gouvêa,Raíssa Leite-Aguiar,Stephanie Alexia Cristina Silva Santos,Fernanda Silva Ferreira,Eduardo Peil Marques,Tatiana Maron-Gutierrez,Eleonora Kurtenbach,Robson da Costa,Cláudia P. Figueiredo,Angela T. S. Wyse,Robson Coutinho-Silva,Luiz Eduardo Baggio Savio +15 more
TL;DR: In this article , the effects of P2X7 receptor activation in neuroinflammatory and behavioral changes in sepsis-surviving mice were evaluated, and it was shown that the modulation of the P2x7 receptor may reduce neuroinflammation and prevent cognitive impairment.
References
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Journal ArticleDOI
A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data.
TL;DR: A new memory test in rats, based on the differential exploration of familiar and new objects, which is comparable to memory tests currently used in man and allows interspecies comparisons.
Journal ArticleDOI
The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
Alicia A. Walf,Cheryl A. Frye +1 more
TL;DR: The elevated plus maze is a widely used behavioral assay for rodents and it has been validated to assess the anti-anxiety effects of pharmacological agents and steroid hormones, and to define brain regions and mechanisms underlying anxiety-related behavior.
Journal ArticleDOI
Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'
Rick A. Bevins,Joyce Besheer +1 more
TL;DR: The object-recognition task has been used to study mutant mice, aging deficits, early developmental influences, nootropic manipulations, teratological drug exposure and novelty seeking.
Journal ArticleDOI
When is the hippocampus involved in recognition memory
TL;DR: The hippocampus plays a role in recognition memory when such memory involves remembering that a particular stimulus occurred in a particular place or when the memory contains a temporal or object recency component.