Journal ArticleDOI
Object recognition test in mice
Marianne Leger,Anne Quiedeville,Valentine Bouet,Benoit Haelewyn,Michel Boulouard,Pascale Schumann-Bard,Thomas Freret +6 more
TLDR
This protocol reduces inter-individual variability with the use of a selection criterion based on a minimal time of exploration for both objects during each session, and describes the three most commonly used variants, containing long (3 d), short (1 d) or no habituation phases.Abstract:
The object recognition test is now among the most commonly used behavioral tests for mice. A mouse is presented with two similar objects during the first session, and then one of the two objects is replaced by a new object during a second session. The amount of time taken to explore the new object provides an index of recognition memory. As more groups have used the protocol, the variability of the procedures used in the object recognition test has increased steadily. This protocol provides a necessary standardization of the procedure. This protocol reduces inter-individual variability with the use of a selection criterion based on a minimal time of exploration for both objects during each session. In this protocol, we describe the three most commonly used variants, containing long (3 d), short (1 d) or no habituation phases. Thus, with a short intersession interval (e.g., 6 h), this procedure can be performed in 4, 2 or 1 d, respectively, according to the duration of the habituation phase. This protocol should allow for the comparison of results from different studies, while permitting adaption of the protocol to the constraints of the experimenter.read more
Citations
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PARIN5, a Novel Thrombin Receptor Antagonist Modulates a Streptozotocin Mice Model for Diabetic Encephalopathy
Valery Golderman,Zehavit Goldberg,Shany Guly Gofrit,Amir Dori,Nicola Maggio,Joab Chapman,Ifat Sher,Ygal Rotenstreich,Efrat Shavit-Stein +8 more
TL;DR: In this paper , a novel PAR1 modulator, PARIN5, was used to prevent behavioral and neural damage in diabetic C57BL/6 mice, which is an inflammation-associated diabetes mellitus (DM) complication.
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Investigating the potential of mirtazapine to induce drug-seeking behavior in free-choice drinking mouse model
TL;DR: In this paper , a free-choice drinking paradigm was used to investigate voluntary drinking of mirtazapine at two different concentrations, i.e., 0.03 and 0.06 mg/mL.
Journal ArticleDOI
Disease-Modifying Effects of a Glial-targeted Inducible Nitric Oxide Synthase Inhibitor (1400W) in Mixed-sex Cohorts of a Rat Soman (GD) Model of Epilepsy
Suraj S. Vasanthi,N.S. Rao,Manikandan Samidurai,Nyzil Massey,Christina Meyer,Meghan Gage,Mihir K Kharate,Aida N. Almanza,Logan Wachter,Lily Trevino,Chongjing Wang,Thimmasettappa Thippeswamy +11 more
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Prenatal stress aggravates age-dependent cognitive decline, insulin signaling dysfunction, and the pro-inflammatory response in the APPNL-F/NL-F mouse model of Alzheimer's disease
Ewa Trojan,Katarzyna Curzytek,Paulina Cieślik,Joanna M. Wierońska,Johannes Graff,Władysław Lasoń,Takashi Saito,Takaomi C. Saido,Agnieszka Basta-Kaim +8 more
TL;DR: In this article , an increase in the Aβ42/Aβ40 ratio and mouse ApoE levels in the hippocampus and frontal cortex preceded the onset of cognitive deficits in the KI mice.
Journal ArticleDOI
The Effects of Galactic Cosmic Rays on the Central Nervous System: From Negative to Unexpectedly Positive Effects That Astronauts May Encounter
V.S. Kokhan,M. I. Dobynde +1 more
TL;DR: In this paper , a review aimed to analyze the studies on the influence of cosmic rays at flight-related doses on physical development, well-being, emotional state, depressive-like behavior, cognition, neurogenesis and the course of neurodegenerative process.
References
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Journal ArticleDOI
A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data.
TL;DR: A new memory test in rats, based on the differential exploration of familiar and new objects, which is comparable to memory tests currently used in man and allows interspecies comparisons.
Journal ArticleDOI
The use of the elevated plus maze as an assay of anxiety-related behavior in rodents
Alicia A. Walf,Cheryl A. Frye +1 more
TL;DR: The elevated plus maze is a widely used behavioral assay for rodents and it has been validated to assess the anti-anxiety effects of pharmacological agents and steroid hormones, and to define brain regions and mechanisms underlying anxiety-related behavior.
Journal ArticleDOI
Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'
Rick A. Bevins,Joyce Besheer +1 more
TL;DR: The object-recognition task has been used to study mutant mice, aging deficits, early developmental influences, nootropic manipulations, teratological drug exposure and novelty seeking.
Journal ArticleDOI
When is the hippocampus involved in recognition memory
TL;DR: The hippocampus plays a role in recognition memory when such memory involves remembering that a particular stimulus occurred in a particular place or when the memory contains a temporal or object recency component.