On the use of corticosteroids for 2019-nCoV pneumonia.
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This article is published in The Lancet.The article was published on 2020-02-29 and is currently open access. It has received 513 citations till now. The article focuses on the topics: Pneumonia & Lung injury.read more
Citations
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Journal ArticleDOI
Dexamethasone in Hospitalized Patients with Covid-19
Peter Horby,Wei Shen Lim,Jonathan Emberson,M Mafham,Jennifer L Bell,Louise Linsell,Natalie Staplin,Christopher E. Brightling,Andrew Ustianowski,E Elmahi,B Prudon,Christopher A Green,Timothy Felton,David Chadwick,K Rege,C Fegan,Lucy C Chappell,Saul N. Faust,Thomas Jaki,Katie Jeffery,Alan A Montgomery,Kathryn M Rowan,Edmund Juszczak,J K Baillie,Richard Haynes,Martin J Landray +25 more
TL;DR: In patients hospitalized with Covid-19, the use of dexamethasone resulted in lower 28-day mortality among those who were receiving either invasive mechanical ventilation or oxygen alone at randomization but not among those receiving no respiratory support.
Journal ArticleDOI
In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2).
Xueting Yao,Fei Ye,Miao Zhang,Cheng Cui,Baoying Huang,Peihua Niu,Xu Liu,Li Zhao,Erdan Dong,Chunli Song,Siyan Zhan,Roujian Lu,Haiyan Li,Wenjie Tan,Dongyang Liu +14 more
TL;DR: It is proposed that the immunomodulatory effect of hydroxychloroquine also may be useful in controlling the cytokine storm that occurs late-phase in critically ill SARS-CoV-2 infected patients.
Journal ArticleDOI
Kidney disease is associated with in-hospital death of patients with COVID-19.
Yichun Cheng,Ran Luo,Kun Wang,Meng Zhang,Zhixiang Wang,Lei Dong,Junhua Li,Ying Yao,Shuwang Ge,Gang Xu +9 more
TL;DR: The findings show the prevalence of kidney disease on admission and the development of AKI during hospitalization in patients with COVID-19 is high and is associated with in-hospital mortality, and clinicians should increase their awareness of kidney patients with severe CO VID-19.
Journal ArticleDOI
Effectiveness of convalescent plasma therapy in severe COVID-19 patients.
Kai Duan,Bende Liu,Li Cesheng,Huajun Zhang,Ting Yu,Jieming Qu,Min Zhou,Li Chen,Shengli Meng,Hu Yong,Cheng Peng,Mingchao Yuan,Jinyan Huang,Zejun Wang,Jianhong Yu,Xiaoxiao Gao,Dan Wang,Xiaoqi Yu,Li Li,Jiayou Zhang,Xiao Wu,Bei Li,Yanping Xu,Wei Chen,Peng Yan,Yeqin Hu,Lin Lianzhen,Xuefei Liu,Shihe Huang,Zhou Zhijun,Lianghao Zhang,Yue Wang,Zhang Zhi,Kun Deng,Zhiwu Xia,Gong Qin,Wei Zhang,Xiaobei Zheng,Ying Liu,Huichuan Yang,Dongbo Zhou,Ding Yu,Jifeng Hou,Zhengli Shi,Sai-Juan Chen,Zhu Chen,Xinxin Zhang,Xiaoming Yang +47 more
TL;DR: CP therapy was well tolerated and could potentially improve the clinical outcomes through neutralizing viremia in severe COVID-19 cases and the optimal dose and time point, as well as the clinical benefit of CP therapy, needs further investigation in larger well-controlled trials.
Journal ArticleDOI
Immunology of COVID-19: Current State of the Science.
Nicolas Vabret,Graham J. Britton,Conor Gruber,Samarth Hegde,Joel Kim,Maria Kuksin,Rachel Levantovsky,Louise Malle,Alvaro Moreira,Matthew D. Park,Luisanna Pia,Emma Risson,Miriam Saffern,Bérengère Salomé,Myvizhi Esai Selvan,Matthew P. Spindler,Jessica Tan,Verena van der Heide,Jill Gregory,Konstantina Alexandropoulos,Nina Bhardwaj,Brian D. Brown,Benjamin Greenbaum,Zeynep H. Gümüş,Dirk Homann,Amir Horowitz,Alice O. Kamphorst,Maria A. Curotto de Lafaille,Saurabh Mehandru,Miriam Merad,Robert M. Samstein,Manasi Agrawal,Mark Aleynick,Meriem Belabed,Matthew Brown,Maria Casanova-Acebes,Jovani Catalan,Monica Centa,Andrew Charap,Andrew K Chan,Steven T. Chen,Jonathan Chung,Cansu Cimen Bozkus,Evan Cody,Francesca Cossarini,Erica Dalla,Nicolas F. Fernandez,John A. Grout,Dan Fu Ruan,Pauline Hamon,Etienne Humblin,Divya Jha,Julia Kodysh,Andrew Leader,Matthew Lin,Katherine E. Lindblad,Daniel Lozano-Ojalvo,Gabrielle Lubitz,Assaf Magen,Zafar Mahmood,Gustavo Martinez-Delgado,Jaime Mateus-Tique,Elliot Meritt,Chang Moon,Justine Noel,Timothy O'Donnell,Miyo Ota,Tamar Plitt,Venu Pothula,Jamie Redes,Ivan Reyes Torres,Mark P. Roberto,Alfonso R. Sanchez-Paulete,Joan Shang,Alessandra Soares Schanoski,Maria Suprun,Michelle Tran,Natalie Vaninov,C. Matthias Wilk,Julio A. Aguirre-Ghiso,Dusan Bogunovic,Judy H. Cho,Jeremiah J. Faith,Emilie K. Grasset,Peter S. Heeger,Ephraim Kenigsberg,Florian Krammer,Uri Laserson +87 more
TL;DR: The current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death are summarized.
References
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Journal ArticleDOI
Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury.
TL;DR: The 2019 novel coronavirus (2019-nCoV) outbreak is a major challenge for clinicians as little data is available that describe the disease pathogenesis, and no pharmacological therapies of proven efficacy yet exist, so understanding the evidence for harm or benefit from corticosteroids in 2019-n coV is of immediate clinical importance.
Journal ArticleDOI
SARS: Systematic Review of Treatment Effects
TL;DR: It was not possible to determine whether treatments benefited patients during the SARS outbreak, but clinical trials should be designed to validate a standard protocol for dosage and timing and to accrue data in real time during future outbreaks to monitor specific adverse effects and help inform treatment.
Journal ArticleDOI
Corticosteroid Therapy for Patients Hospitalized With Community-Acquired Pneumonia: A Systematic Review and Meta-analysis.
Reed A C Siemieniuk,Maureen O. Meade,Pablo Alonso-Coello,Matthias Briel,Nathan Evaniew,Manya Prasad,Paul E. Alexander,Yutong Fei,Per Olav Vandvik,Mark Loeb,Gordon H. Guyatt +10 more
TL;DR: A systematic review and meta-analysis evaluating the effect of adjunctive corticosteroid therapy for patients hospitalized with community-acquired pneumonia and the possibility of publication bias was performed.
Journal ArticleDOI
Treatment of Severe Acute Respiratory Syndrome With Glucosteroids: The Guangzhou Experience
Rongchang Chen,Xiao Ping Tang,Shou Yong Tan,Bi Ling Liang,Zhuo Yue Wan,Ji Qian Fang,Nanshan Zhong +6 more
TL;DR: Wang et al. as mentioned in this paper investigated the efficacy and safety profiles of corticosteroid therapy in severe acute respiratory syndrome (SARS) patients, and found that proper use of the drug in confirmed critical SARS resulted in lowered mortality and shorter hospitalization stay.
Journal ArticleDOI
Effect of low-to-moderate-dose corticosteroids on mortality of hospitalized adolescents and adults with influenza A(H1N1)pdm09 viral pneumonia.
Hui Li,Shigui Yang,Li Gu,Yao Zhang,Xi-xin Yan,Zongan Liang,Wei Zhang,Hongyu Jia,Wei Chen,Meng Liu,Kai-Jiang Yu,Chunxue Xue,Ke Hu,Qi Zou,Lanjuan Li,Bin Cao,Chen Wang +16 more
TL;DR: The effect of corticosteroids on influenza A(H1N1)pdm09 viral pneumonia patients remains controversial, and the impact of dosage has never been studied.
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