Journal ArticleDOI
Oncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease
Raffaella Molteni,Riccardo Biavasco,Davide Stefanoni,Davide Stefanoni,Travis Nemkov,Jorge Domínguez-Andrés,Rob J.W. Arts,Ivan Merelli,Davide Mazza,Samuel Zambrano,Maddalena Panigada,Eleonora Cantoni,Isak W. Tengesdal,Isak W. Tengesdal,Philippe Maksud,Francesco Piras,Daniela Cesana,Laura Cassina,Gianfranco Distefano,Alessia Loffreda,Daniela Gnani,Giacomo De Luca,Alessandro Tomelleri,Corrado Campochiaro,Leo A. B. Joosten,Leo A. B. Joosten,Charles A. Dinarello,Charles A. Dinarello,Anna Kajaste-Rudnitski,Julien Haroche,Simone Cardaci,Simone Cenci,Lorenzo Dagna,Claudio Doglioni,Marina Ferrarini,Elisabetta Ferrero,Alessandra Boletta,Angelo D'Alessandro,Eugenio Montini,Mihai G. Netea,Mihai G. Netea,Giulio Cavalli +41 more
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TLDR
In this article, the authors uncovered the oncogene-induced, maladaptive induction of trained immunity in the pathogenesis of a human inflammatory myeloid neoplasm (Erdheim-Chester disease, [ECD]), characterized by the BRAFV600E oncogenic mutation in monocyte/macrophages and excess cytokine production.About:
This article is published in Blood.The article was published on 2021-10-28. It has received 8 citations till now. The article focuses on the topics: Proinflammatory cytokine & Cytokine.read more
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Journal ArticleDOI
IL-1 family cytokines as drivers and inhibitors of trained immunity
Lisa U. Teufel,Leo A. B. Joosten,Rob J.W. Arts,Mihai G. Netea,Charles A. Dinarello,Leo A. B. Joosten +5 more
TL;DR: In this article, the role of anti-inflammatory members of the IL-1 family of cytokines (IL-1F) which interfere with the inflammatory process has been discussed, with the potential to regulate the induction of a trained phenotype.
Journal ArticleDOI
Trained immunity: A Yin‐Yang balance
TL;DR: This is the first time to put forward the theory of Yin‐Yang balance to understand trained immunity, and it is envisioned that more efforts will be focused on developing novel immunotherapies targeting trained immunity in the coming years.
Journal ArticleDOI
BRAF Modulates Lipid Use and Accumulation
Jacqueline A. Turner,Emily L. Paton,Robert Van Gulick,Davide Stefanoni,Francesca Cendali,Julie A. Reisz,Richard P Tobin,Martin D. McCarter,Angelo D'Alessandro,Raul M. Torres,William A. Robinson,Kasey L. Couts,Isabel R. Schlaepfer +12 more
TL;DR: The findings indicate that targeting lipid metabolism may be a potential alternative strategy to improve patient responses to BRAF-targeted therapies and show BRAF V600 status plays an important role in regulating immunomodulatory lipid profiles and lipid trafficking, which may inform future therapy across cancers.
Journal ArticleDOI
Interleukin-1α: Novel functions in cell senescence and antiviral response.
TL;DR: The interleukin-1 proteins are a hub of innate inflammatory signaling that activates diverse aspects of adaptive immunity as mentioned in this paper , and they localize to the nucleus, cytoplasm, mitochondria, cell membrane or extracellular space in various contexts.
Journal ArticleDOI
Pancreatic involvement in Erdheim-Chester disease: a case report and review of the literature
TL;DR: A 29-year-old female with menoxenia, diabetes insipidus and diabetes mellitus was diagnosed with Erdheim-Chester disease (ECD) and treated with high-dose IFN-α as discussed by the authors .
References
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Journal ArticleDOI
A guide to immunometabolism for immunologists
TL;DR: A brief refresher course on six of the major metabolic pathways involved in immunometabolism is provided, giving specific examples of how precise changes in the metabolites of these pathways shape the immune cell response.
Journal ArticleDOI
Trained immunity: A program of innate immune memory in health and disease
Mihai G. Netea,Leo A. B. Joosten,Eicke Latz,Kingston H. G. Mills,Gioacchino Natoli,Hendrik G. Stunnenberg,Luke A. J. O'Neill,Ramnik J. Xavier +7 more
TL;DR: Proof-of-principle experimental studies support the hypothesis that trained immunity is one of the main immunological processes that mediate the nonspecific protective effects against infections induced by vaccines, such as bacillus Calmette-Guérin or measles vaccination.
Journal ArticleDOI
mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
Shih-Chin Cheng,Jessica Quintin,Robert A. Cramer,Kelly M. Shepardson,Sadia Saeed,Vinod Kumar,Evangelos J. Giamarellos-Bourboulis,Joost H.A. Martens,Nagesha Appukudige Rao,Ali Aghajanirefah,Ganesh R. Manjeri,Yang Li,Daniela C. Ifrim,Rob J.W. Arts,Brian M. J. W. van der Veer,Peter M.T. Deen,Colin Logie,Luke A. J. O'Neill,Peter H.G.M. Willems,Frank L. van de Veerdonk,Jos W. M. van der Meer,Aylwin Ng,Aylwin Ng,Leo A. B. Joosten,Cisca Wijmenga,Hendrik G. Stunnenberg,Ramnik J. Xavier,Ramnik J. Xavier,Mihai G. Netea +28 more
TL;DR: The identification of glycolysis as a fundamental process in trained immunity further highlights a key regulatory role for metabolism in innate host defense and defines a potential therapeutic target in both infectious and inflammatory diseases.
Journal ArticleDOI
Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
Sadia Saeed,Jessica Quintin,Hindrik H. D. Kerstens,Nagesha A.S. Rao,Ali Aghajanirefah,Filomena Matarese,Shih-Chin Cheng,Jacqueline M. Ratter,Kim Berentsen,Martijn van der Ent,Nilofar Sharifi,Eva M. Janssen-Megens,Menno ter Huurne,Amit Mandoli,Tom van Schaik,Aylwin Ng,Aylwin Ng,Frances Burden,Kate Downes,Mattia Frontini,Vinod Kumar,Evangelos J. Giamarellos-Bourboulis,Willem H. Ouwehand,Jos W. M. van der Meer,Leo A. B. Joosten,Cisca Wijmenga,Joost H.A. Martens,Ramnik J. Xavier,Ramnik J. Xavier,Colin Logie,Mihai G. Netea,Hendrik G. Stunnenberg +31 more
TL;DR: The epigenetic and transcriptional programs of monocyte differentiation to macrophages that distinguish tolerant and trained macrophage phenotypes are uncovered, providing a resource to further understand and manipulate immune-mediated responses.
Journal ArticleDOI
Defining trained immunity and its role in health and disease
Mihai G. Netea,Mihai G. Netea,Jorge Domínguez-Andrés,Luis B. Barreiro,Luis B. Barreiro,Triantafyllos Chavakis,Triantafyllos Chavakis,Maziar Divangahi,Maziar Divangahi,Elaine Fuchs,Leo A. B. Joosten,Jos W. M. van der Meer,Musa M. Mhlanga,Musa M. Mhlanga,Willem J. M. Mulder,Willem J. M. Mulder,Niels P. Riksen,Andreas Schlitzer,Joachim L. Schultze,Christine Stabell Benn,Joseph C. Sun,Joseph C. Sun,Ramnik J. Xavier,Ramnik J. Xavier,Eicke Latz,Eicke Latz,Eicke Latz +26 more
TL;DR: A group of leaders in the field define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.