OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
Christian Frezza,Sara Cipolat,Olga Martins de Brito,Massimo Micaroni,Galina V. Beznoussenko,Tomasz Rudka,Davide Bartoli,Roman S. Polishuck,Nika N. Danial,Bart De Strooper,Luca Scorrano +10 more
TLDR
Evidence is provided that Optic Atrophy 1 (OPA1), a profusion dynamin-related protein of the inner mitochondrial membrane mutated in dominant optic atrophy, protects from apoptosis by preventing cytochrome c release independently from mitochondrial fusion.About:
This article is published in Cell.The article was published on 2006-07-14 and is currently open access. It has received 1444 citations till now. The article focuses on the topics: Optic Atrophy 1 & Inner mitochondrial membrane.read more
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Journal ArticleDOI
Keeping mitochondria in shape: a matter of life and death.
TL;DR: Mitochondria are dynamic organelles that participate in energy conversion, metabolism, signaling and apoptosis and are in close contact with the endoplasmic reticulum generating an essential interface in cell physiology and death.
Journal ArticleDOI
Regulation of mitochondrial morphological dynamics during apoptosis by Bcl-2 family proteins: a key in Bak?
Craig R. Brooks,Zheng Dong +1 more
TL;DR: Emerging evidence has now suggested a regulation of mitochondrial morphological dynamics by Bcl-2 family proteins, and Bak appears to be a key in this regulation.
Journal ArticleDOI
Regulated membrane remodeling by Mic60 controls formation of mitochondrial crista junctions
Manuel Hessenberger,Manuel Hessenberger,Ralf M. Zerbes,Heike Rampelt,Séverine Kunz,Audrey Xavier,Audrey Xavier,Bettina Purfürst,Hauke Lilie,Nikolaus Pfanner,Martin van der Laan,Oliver Daumke,Oliver Daumke +12 more
TL;DR: It is reported that Mic60 deforms liposomes into thin membrane tubules and thus displays membrane-shaping activity, and a membrane-binding site is identified in the soluble intermembrane space-exposed part of Mic60.
Book ChapterDOI
Drosophila Models of Parkinson's Disease
TL;DR: The methodologies employed in developing the various Drosophila models, and the recent advances that these models in particular have contributed to the understanding of the mechanisms that underlie PD pathogenesis and possible treatment strategies are reviewed.
Journal ArticleDOI
Structural implications of mitochondrial dynamics.
TL;DR: Electron micrographs of serial sections of human umbilical vein endothelial cells reveal perinuclear mitochondria of extreme length and with branches in those cells that also have short peripheral mitochondria, indicating novel fast inner membrane reorganizations.
References
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Journal ArticleDOI
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
Michael C. Wei,Michael C. Wei,Wei-Xing Zong,Emily H. Cheng,Tullia Lindsten,Vily Panoutsakopoulou,Andrea J. Ross,Kevin A. Roth,Grant R. MacGregor,Craig B. Thompson,Stanley J. Korsmeyer +10 more
TL;DR: In this article, the authors found that doubly deficient cells are resistant to multiple apoptotic stimuli that act through disruption of mitochondrial function: staurosporine, ultraviolet radiation, growth factor deprivation, etoposide, and the endoplasmic reticulum stress stimuli thapsigargin and tunicamycin.
Journal ArticleDOI
The Pathophysiology of Mitochondrial Cell Death
Douglas R. Green,Guido Kroemer +1 more
TL;DR: The therapeutic induction of MOMP may restore apoptosis in cancer cells in which it is disabled, and the general rules governing the pathophysiology and controversial issues regarding its regulation are discussed.
Journal ArticleDOI
Two CD95 (APO-1/Fas) signaling pathways
Carsten Scaffidi,Simone Fulda,Anu Srinivasan,Claudia Friesen,Feng Li,Kevin J. Tomaselli,Klaus-Michael Debatin,Peter H. Krammer,Marcus E. Peter +8 more
TL;DR: In the presence of caspase‐3 the amount of active casp enzyme‐8 generated at the DISC determines whether a mitochondria‐independent apoptosis pathway is used (type I cells) or not (type II cells).
Journal Article
The expanding role of mitochondria in apoptosis
TL;DR: The complexity of the apoptotic program began to increase with the discovery of Bcl-2, a gene whose product causes resistance to apoptosis in lymphocytes, and the complex role of mitochondria in apoptosis came into focus when biochemical studies identified several mitochondrial proteins that are able to activate cellular apoptotic programs directly.
Journal ArticleDOI
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
TL;DR: It is concluded that Mfn1 and Mfn2 have both redundant and distinct functions and act in three separate molecular complexes to promote mitochondrial fusion, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population.