OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
Christian Frezza,Sara Cipolat,Olga Martins de Brito,Massimo Micaroni,Galina V. Beznoussenko,Tomasz Rudka,Davide Bartoli,Roman S. Polishuck,Nika N. Danial,Bart De Strooper,Luca Scorrano +10 more
TLDR
Evidence is provided that Optic Atrophy 1 (OPA1), a profusion dynamin-related protein of the inner mitochondrial membrane mutated in dominant optic atrophy, protects from apoptosis by preventing cytochrome c release independently from mitochondrial fusion.About:
This article is published in Cell.The article was published on 2006-07-14 and is currently open access. It has received 1444 citations till now. The article focuses on the topics: Optic Atrophy 1 & Inner mitochondrial membrane.read more
Citations
More filters
Journal ArticleDOI
Mff‐Dependent Mitochondrial Fission Contributes to the Pathogenesis of Cardiac Microvasculature Ischemia/Reperfusion Injury via Induction of mROS‐Mediated Cardiolipin Oxidation and HK2/VDAC1 Disassociation‐Involved mPTP Opening
Hao Zhou,Shunying Hu,Qinhua Jin,Chen Shi,Ying Zhang,Pingjun Zhu,Qiang Ma,Feng Tian,Yundai Chen +8 more
TL;DR: Evidence clearly illustrates that microcirculatory ischemia/reperfusion injury can be attributed to Mff‐dependent mitochondrial fission via voltage‐dependent anion channel 1/hexokinase 2–mediated mitochondrial permeability transition pore opening and mitochondrial reactive oxygen species/cardiolipin involved cyt‐c release.
Journal ArticleDOI
Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy
Riccardo Calvani,Anna-Maria Joseph,Peter J. Adhihetty,Alfredo Miccheli,Maurizio Bossola,Christiaan Leeuwenburgh,Roberto Bernabei,Emanuele Marzetti +7 more
TL;DR: Current knowledge on the mechanisms whereby mitochondrial dysfunction intervenes in the pathogenesis of sarcopenia and disuse atrophy are summarized, and the prospect of targeting specific processes to treat these conditions is highlighted.
Journal ArticleDOI
High levels of Fis1, a pro-fission mitochondrial protein, trigger autophagy.
Ligia C. Gomes,Luca Scorrano +1 more
TL;DR: Fission associated with mitochondrial dysfunction stimulates an increase in autophagy, as substantiated by Fis1 mutants with different effects on organelle shape and function.
Journal ArticleDOI
How Mitochondrial Dynamism Orchestrates Mitophagy
TL;DR: Accumulating evidence supporting important roles for mitochondrial fission and fusion in cardiac mitochondrial quality control is reviewed, focusing on the PTEN-induced putative kinase 1-Parkin mitophagy pathway.
Journal ArticleDOI
Stress‐induced OMA1 activation and autocatalytic turnover regulate OPA1‐dependent mitochondrial dynamics
Michael J. Baker,Philipp A Lampe,Diana Stojanovski,Anne Korwitz,Ruchika Anand,Takashi Tatsuta,Thomas Langer +6 more
TL;DR: An amino terminal stress‐sensor domain of OMA1 is identified, which is only present in homologues of higher eukaryotes and which modulates Oma1 proteolysis and activation and maintains the functional integrity of mitochondria and contributes to cell survival.
References
More filters
Journal ArticleDOI
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
Michael C. Wei,Michael C. Wei,Wei-Xing Zong,Emily H. Cheng,Tullia Lindsten,Vily Panoutsakopoulou,Andrea J. Ross,Kevin A. Roth,Grant R. MacGregor,Craig B. Thompson,Stanley J. Korsmeyer +10 more
TL;DR: In this article, the authors found that doubly deficient cells are resistant to multiple apoptotic stimuli that act through disruption of mitochondrial function: staurosporine, ultraviolet radiation, growth factor deprivation, etoposide, and the endoplasmic reticulum stress stimuli thapsigargin and tunicamycin.
Journal ArticleDOI
The Pathophysiology of Mitochondrial Cell Death
Douglas R. Green,Guido Kroemer +1 more
TL;DR: The therapeutic induction of MOMP may restore apoptosis in cancer cells in which it is disabled, and the general rules governing the pathophysiology and controversial issues regarding its regulation are discussed.
Journal ArticleDOI
Two CD95 (APO-1/Fas) signaling pathways
Carsten Scaffidi,Simone Fulda,Anu Srinivasan,Claudia Friesen,Feng Li,Kevin J. Tomaselli,Klaus-Michael Debatin,Peter H. Krammer,Marcus E. Peter +8 more
TL;DR: In the presence of caspase‐3 the amount of active casp enzyme‐8 generated at the DISC determines whether a mitochondria‐independent apoptosis pathway is used (type I cells) or not (type II cells).
Journal Article
The expanding role of mitochondria in apoptosis
TL;DR: The complexity of the apoptotic program began to increase with the discovery of Bcl-2, a gene whose product causes resistance to apoptosis in lymphocytes, and the complex role of mitochondria in apoptosis came into focus when biochemical studies identified several mitochondrial proteins that are able to activate cellular apoptotic programs directly.
Journal ArticleDOI
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
TL;DR: It is concluded that Mfn1 and Mfn2 have both redundant and distinct functions and act in three separate molecular complexes to promote mitochondrial fusion, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population.