OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
Christian Frezza,Sara Cipolat,Olga Martins de Brito,Massimo Micaroni,Galina V. Beznoussenko,Tomasz Rudka,Davide Bartoli,Roman S. Polishuck,Nika N. Danial,Bart De Strooper,Luca Scorrano +10 more
TLDR
Evidence is provided that Optic Atrophy 1 (OPA1), a profusion dynamin-related protein of the inner mitochondrial membrane mutated in dominant optic atrophy, protects from apoptosis by preventing cytochrome c release independently from mitochondrial fusion.About:
This article is published in Cell.The article was published on 2006-07-14 and is currently open access. It has received 1444 citations till now. The article focuses on the topics: Optic Atrophy 1 & Inner mitochondrial membrane.read more
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The role of the mitochondria and the endoplasmic reticulum contact sites in the development of the immune responses.
TL;DR: Some of these functions are strongly dependent on lipid transfer, autophagosome formation, mitochondrial fission, and Ca2+ flux; this indicates that MERCs could regulate immunity.
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Novel mitochondrial protein interactors of immunoglobulin light chains causing heart amyloidosis
Francesca Lavatelli,Esther Imperlini,Stefania Orrù,Paola Rognoni,Daniela Sarnataro,Giuseppina Palladini,Giuseppe Malpasso,Maria Eugenia Soriano,Andrea di Fonzo,Veronica Valentini,Massimiliano Gnecchi,Stefano Perlini,Francesco Salvatore,Giampaolo Merlini +13 more
TL;DR: It is shown that cardiotoxic LCs establish nonphysiologic protein‐protein contacts in human cardiac cells, offering new clues on the pathogenesis of AL cardiomyopathy.
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Posttranslational modifications of mitochondrial fission and fusion proteins in cardiac physiology and pathophysiology.
Stephanie M. Adaniya,Stephanie M. Adaniya,Jin O-Uchi,Michael W. Cypress,Yoichiro Kusakari,Bong Sook Jhun +5 more
TL;DR: The molecular mechanisms underlying abnormal mitochondrial morphology in HF and their contributions to the development of cardiac diseases are discussed, highlighting the crucial roles of PTMs of mitochondrial fission and fusion proteins.
Journal ArticleDOI
Mitochondrial dynamics regulating chemoresistance in gynecological cancers.
Bao Kong,Bao Kong,Hideaki Tsuyoshi,Hideaki Tsuyoshi,Hideaki Tsuyoshi,Makoto Orisaka,Dar-Bin Shieh,Yoshio Yoshida,Benjamin K. Tsang,Benjamin K. Tsang +9 more
TL;DR: Understanding the regulation of mitochondrial dynamics in chemoresistance may provide insight into new biomarkers that better predict cancer chemosensitivity and may aid the development of effective therapeutic strategies for clinical management of gynecologic cancers.
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Putting the pieces together: How is the mitochondrial pathway of apoptosis regulated in cancer and chemotherapy?
TL;DR: This review presents the pathways that govern the cellular decision to undergo apoptosis as three distinct, yet connected puzzle pieces and potentially reveals novel pharmacological targets within these pathways that may enhance chemotherapeutic success.
References
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Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
Michael C. Wei,Michael C. Wei,Wei-Xing Zong,Emily H. Cheng,Tullia Lindsten,Vily Panoutsakopoulou,Andrea J. Ross,Kevin A. Roth,Grant R. MacGregor,Craig B. Thompson,Stanley J. Korsmeyer +10 more
TL;DR: In this article, the authors found that doubly deficient cells are resistant to multiple apoptotic stimuli that act through disruption of mitochondrial function: staurosporine, ultraviolet radiation, growth factor deprivation, etoposide, and the endoplasmic reticulum stress stimuli thapsigargin and tunicamycin.
Journal ArticleDOI
The Pathophysiology of Mitochondrial Cell Death
Douglas R. Green,Guido Kroemer +1 more
TL;DR: The therapeutic induction of MOMP may restore apoptosis in cancer cells in which it is disabled, and the general rules governing the pathophysiology and controversial issues regarding its regulation are discussed.
Journal ArticleDOI
Two CD95 (APO-1/Fas) signaling pathways
Carsten Scaffidi,Simone Fulda,Anu Srinivasan,Claudia Friesen,Feng Li,Kevin J. Tomaselli,Klaus-Michael Debatin,Peter H. Krammer,Marcus E. Peter +8 more
TL;DR: In the presence of caspase‐3 the amount of active casp enzyme‐8 generated at the DISC determines whether a mitochondria‐independent apoptosis pathway is used (type I cells) or not (type II cells).
Journal Article
The expanding role of mitochondria in apoptosis
TL;DR: The complexity of the apoptotic program began to increase with the discovery of Bcl-2, a gene whose product causes resistance to apoptosis in lymphocytes, and the complex role of mitochondria in apoptosis came into focus when biochemical studies identified several mitochondrial proteins that are able to activate cellular apoptotic programs directly.
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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
TL;DR: It is concluded that Mfn1 and Mfn2 have both redundant and distinct functions and act in three separate molecular complexes to promote mitochondrial fusion, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population.