OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
Christian Frezza,Sara Cipolat,Olga Martins de Brito,Massimo Micaroni,Galina V. Beznoussenko,Tomasz Rudka,Davide Bartoli,Roman S. Polishuck,Nika N. Danial,Bart De Strooper,Luca Scorrano +10 more
TLDR
Evidence is provided that Optic Atrophy 1 (OPA1), a profusion dynamin-related protein of the inner mitochondrial membrane mutated in dominant optic atrophy, protects from apoptosis by preventing cytochrome c release independently from mitochondrial fusion.About:
This article is published in Cell.The article was published on 2006-07-14 and is currently open access. It has received 1444 citations till now. The article focuses on the topics: Optic Atrophy 1 & Inner mitochondrial membrane.read more
Citations
More filters
Journal ArticleDOI
Mitochondrial fragmentation in apoptosis.
TL;DR: It is concluded that mitochondrial fragmentation is probably not a prerequisite for MOMP and cytochrome c release and, in fact, fragmentation even inhibits MOMp.
Journal ArticleDOI
Barth syndrome: cellular compensation of mitochondrial dysfunction and apoptosis inhibition due to changes in cardiolipin remodeling linked to tafazzin (TAZ) gene mutation.
Francois Gonzalvez,Marilena D'Aurelio,Marie Boutant,Aoula Moustapha,Jean-Philippe Puech,Thomas Landes,Laeticia Arnauné-Pelloquin,Guillaume Vial,Nellie Taleux,Christian Slomianny,Ronald J.A. Wanders,Riekelt H. Houtkooper,Pascale Bellenguer,Ian M. Møller,Eyal Gottlieb,Frédéric M. Vaz,Giovanni Manfredi,Patrice X. Petit +17 more
TL;DR: It is shown that the production of abnormal cardiolipin led to mitochondrial alterations, that the type II apoptosis pathway was blocked at the mitochondrial level and that the mitochondria of patients with Barth syndrome cannot bind active caspase-8 and signal transduction is blocked before any mitochondrial event can occur.
Journal ArticleDOI
Diet impact on mitochondrial bioenergetics and dynamics
TL;DR: Emerging findings revealed an important role for mitochondrial dynamics within neuronal populations involved in central regulation of body energy balance and diet impact on metabolic tissues.
Journal ArticleDOI
Mitochondrial dysfunction in glaucoma and emerging bioenergetic therapies
Shanjean Lee,Nicole J Van Bergen,George Kong,Vicki Chrysostomou,Hayley S Waugh,Evelyn C O'Neill,Jonathan G Crowston,Ian A. Trounce +7 more
TL;DR: If primary or secondary mitochondrial dysfunction is further established as contributing to glaucoma pathogenesis, emerging therapies aimed at optimizing mitochondrial function represent potentially exciting new clinical treatments that may slow retinal ganglion cell and vision loss in glau coma.
Journal ArticleDOI
Role of MINOS in mitochondrial membrane architecture and biogenesis
TL;DR: It is proposed that MINOS forms a central part of an ER-mitochondria organizing network (ERMIONE) that controls mitochondrial membrane architecture and biogenesis.
References
More filters
Journal ArticleDOI
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
Michael C. Wei,Michael C. Wei,Wei-Xing Zong,Emily H. Cheng,Tullia Lindsten,Vily Panoutsakopoulou,Andrea J. Ross,Kevin A. Roth,Grant R. MacGregor,Craig B. Thompson,Stanley J. Korsmeyer +10 more
TL;DR: In this article, the authors found that doubly deficient cells are resistant to multiple apoptotic stimuli that act through disruption of mitochondrial function: staurosporine, ultraviolet radiation, growth factor deprivation, etoposide, and the endoplasmic reticulum stress stimuli thapsigargin and tunicamycin.
Journal ArticleDOI
The Pathophysiology of Mitochondrial Cell Death
Douglas R. Green,Guido Kroemer +1 more
TL;DR: The therapeutic induction of MOMP may restore apoptosis in cancer cells in which it is disabled, and the general rules governing the pathophysiology and controversial issues regarding its regulation are discussed.
Journal ArticleDOI
Two CD95 (APO-1/Fas) signaling pathways
Carsten Scaffidi,Simone Fulda,Anu Srinivasan,Claudia Friesen,Feng Li,Kevin J. Tomaselli,Klaus-Michael Debatin,Peter H. Krammer,Marcus E. Peter +8 more
TL;DR: In the presence of caspase‐3 the amount of active casp enzyme‐8 generated at the DISC determines whether a mitochondria‐independent apoptosis pathway is used (type I cells) or not (type II cells).
Journal Article
The expanding role of mitochondria in apoptosis
TL;DR: The complexity of the apoptotic program began to increase with the discovery of Bcl-2, a gene whose product causes resistance to apoptosis in lymphocytes, and the complex role of mitochondria in apoptosis came into focus when biochemical studies identified several mitochondrial proteins that are able to activate cellular apoptotic programs directly.
Journal ArticleDOI
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
TL;DR: It is concluded that Mfn1 and Mfn2 have both redundant and distinct functions and act in three separate molecular complexes to promote mitochondrial fusion, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population.