OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
Christian Frezza,Sara Cipolat,Olga Martins de Brito,Massimo Micaroni,Galina V. Beznoussenko,Tomasz Rudka,Davide Bartoli,Roman S. Polishuck,Nika N. Danial,Bart De Strooper,Luca Scorrano +10 more
TLDR
Evidence is provided that Optic Atrophy 1 (OPA1), a profusion dynamin-related protein of the inner mitochondrial membrane mutated in dominant optic atrophy, protects from apoptosis by preventing cytochrome c release independently from mitochondrial fusion.About:
This article is published in Cell.The article was published on 2006-07-14 and is currently open access. It has received 1444 citations till now. The article focuses on the topics: Optic Atrophy 1 & Inner mitochondrial membrane.read more
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Regulation of Mitochondrial Electron Transport Chain Assembly.
TL;DR: The initial idea that the respiratory chain protein complexes (RCCs) were independent structures in the inner mitochondrial membrane evolved after the identification of higher quaternary structures called supercomplexes (SCs), whose formation is dynamically regulated in order to accommodate cellular metabolic demands.
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Genome-wide linkage scan and association study of PARL to the expression of LHON families in Thailand
Nopasak Phasukkijwatana,Bussaraporn Kunhapan,Jim Stankovich,Jim Stankovich,Wanicha Chuenkongkaew,Russell Thomson,Timothy A. Thornton,Melanie Bahlo,Taisei Mushiroda,Yusuke Nakamura,Surakameth Mahasirimongkol,Aung Win Tun,Chatchawan Srisawat,Chanin Limwongse,Chayanon Peerapittayamongkol,Thanyachai Sura,Wichit Suthammarak,Patcharee Lertrit +17 more
TL;DR: A genome-wide linkage scan with 400 microsatellite markers in 9 large Thai LHON G11778A pedigrees showed the most evidence of association between two SNPs, rs3749446 and rs1402000, located in PARL presenilins-associated rhomboid-like and LHON expression, which has long been believed to intrigue the neurodegeneration of LHON.
Journal ArticleDOI
Mitochondrial quality control mechanisms as potential therapeutic targets in sepsis-induced multiple organ failure.
TL;DR: This review will focus on advances concerning potential mechanisms in regulating mitochondria quality control and impacts of mitochondrial quality control on the progression of sepsis.
Journal ArticleDOI
OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development
Zhida Wu,Meiling Zuo,Ling Zeng,Kaisa Cui,Bing Liu,Chaojun Yan,Li Chen,Jun Dong,Fugen Shangguan,Wanglai Hu,He He,Bin Lu,Zhiyin Song +12 more
TL;DR: It is demonstrated that OMA1, a stress‐activated mitochondrial protease, promotes colorectal cancer development by driving metabolic reprogramming and suppresses OXPHOS in coloreCTal cancer models.
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Cell death: Insights into the ultrastructure of mitochondria
TL;DR: The current knowledge of mitochondrial inner membrane remodelling during cell death is summarized and the role of mitochondrial proteins in governing structural alterations is discussed, including the adaptor protein p66Shc as a regulator of mitochondrial metabolism during apoptosis.
References
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Journal ArticleDOI
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
Michael C. Wei,Michael C. Wei,Wei-Xing Zong,Emily H. Cheng,Tullia Lindsten,Vily Panoutsakopoulou,Andrea J. Ross,Kevin A. Roth,Grant R. MacGregor,Craig B. Thompson,Stanley J. Korsmeyer +10 more
TL;DR: In this article, the authors found that doubly deficient cells are resistant to multiple apoptotic stimuli that act through disruption of mitochondrial function: staurosporine, ultraviolet radiation, growth factor deprivation, etoposide, and the endoplasmic reticulum stress stimuli thapsigargin and tunicamycin.
Journal ArticleDOI
The Pathophysiology of Mitochondrial Cell Death
Douglas R. Green,Guido Kroemer +1 more
TL;DR: The therapeutic induction of MOMP may restore apoptosis in cancer cells in which it is disabled, and the general rules governing the pathophysiology and controversial issues regarding its regulation are discussed.
Journal ArticleDOI
Two CD95 (APO-1/Fas) signaling pathways
Carsten Scaffidi,Simone Fulda,Anu Srinivasan,Claudia Friesen,Feng Li,Kevin J. Tomaselli,Klaus-Michael Debatin,Peter H. Krammer,Marcus E. Peter +8 more
TL;DR: In the presence of caspase‐3 the amount of active casp enzyme‐8 generated at the DISC determines whether a mitochondria‐independent apoptosis pathway is used (type I cells) or not (type II cells).
Journal Article
The expanding role of mitochondria in apoptosis
TL;DR: The complexity of the apoptotic program began to increase with the discovery of Bcl-2, a gene whose product causes resistance to apoptosis in lymphocytes, and the complex role of mitochondria in apoptosis came into focus when biochemical studies identified several mitochondrial proteins that are able to activate cellular apoptotic programs directly.
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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
TL;DR: It is concluded that Mfn1 and Mfn2 have both redundant and distinct functions and act in three separate molecular complexes to promote mitochondrial fusion, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population.