OPA1 Controls Apoptotic Cristae Remodeling Independently from Mitochondrial Fusion
Christian Frezza,Sara Cipolat,Olga Martins de Brito,Massimo Micaroni,Galina V. Beznoussenko,Tomasz Rudka,Davide Bartoli,Roman S. Polishuck,Nika N. Danial,Bart De Strooper,Luca Scorrano +10 more
TLDR
Evidence is provided that Optic Atrophy 1 (OPA1), a profusion dynamin-related protein of the inner mitochondrial membrane mutated in dominant optic atrophy, protects from apoptosis by preventing cytochrome c release independently from mitochondrial fusion.About:
This article is published in Cell.The article was published on 2006-07-14 and is currently open access. It has received 1444 citations till now. The article focuses on the topics: Optic Atrophy 1 & Inner mitochondrial membrane.read more
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Too much death can kill you: inhibiting intrinsic apoptosis to treat disease
TL;DR: In this article, the authors describe several key steps in the intrinsic (mitochondrial) apoptosis pathway that represent potential targets for inhibitors in disease contexts and discuss the mechanisms of action, advantages and limitations of small-molecule and peptide-based inhibitors.
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Solving a 50 year mystery of a missing OPA1 mutation: more insights from the first family diagnosed with autosomal dominant optic atrophy
Nico Fuhrmann,Simone Schimpf,York Kamenisch,Beate Leo-Kottler,Christiane Alexander,Georg Auburger,Eberhart Zrenner,Bernd Wissinger,Marcel V. Alavi +8 more
TL;DR: Cell biological findings suggest that OPA1 is regulated by post-translational mechanisms and it is hypothesize that loss of OPA2 function might lead to impaired mitochondrial quality control and more than half a century of research in optic neuropathies.
Journal ArticleDOI
Effect of crista morphology on mitochondrial ATP output: A computational study.
TL;DR: Simulations demonstrate that cristae are micro-compartments functionally distinct from the cytosol and the crucial role played by intracristal kinases (adenylate kinase, creatine kinase) in maintaining the energy advantage of IM folding.
Journal ArticleDOI
Tracking intra- and inter-organelle signaling of mitochondria.
Corina T. Madreiter-Sokolowski,Corina T. Madreiter-Sokolowski,Jeta Ramadani-Muja,Gabriela Ziomek,Sandra Burgstaller,Helmut Bischof,Zhanat Koshenov,Benjamin Gottschalk,Roland Malli,Wolfgang F. Graier +9 more
TL;DR: This review provides an up‐to‐date overview on mitochondrial strategies to adapt and respond to, as well as affect, their cellular environment and presents cutting‐edge technologies used to track and investigate subcellular signaling.
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Molecular and topological reorganizations in mitochondrial architecture interplay during Bax-mediated steps of apoptosis
Nicholas R. Ader,Patrick C. Hoffmann,Iva Ganeva,Alicia C. Borgeaud,Chunxin Wang,Richard J. Youle,Wanda Kukulski +6 more
TL;DR: A comprehensive model is proposed in which molecular reorganizations of the inner membrane and sequestration of outer membrane components into Bax clusters interplay in the formation of inner membrane ruptures of highly variable size.
References
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Journal ArticleDOI
Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death
Michael C. Wei,Michael C. Wei,Wei-Xing Zong,Emily H. Cheng,Tullia Lindsten,Vily Panoutsakopoulou,Andrea J. Ross,Kevin A. Roth,Grant R. MacGregor,Craig B. Thompson,Stanley J. Korsmeyer +10 more
TL;DR: In this article, the authors found that doubly deficient cells are resistant to multiple apoptotic stimuli that act through disruption of mitochondrial function: staurosporine, ultraviolet radiation, growth factor deprivation, etoposide, and the endoplasmic reticulum stress stimuli thapsigargin and tunicamycin.
Journal ArticleDOI
The Pathophysiology of Mitochondrial Cell Death
Douglas R. Green,Guido Kroemer +1 more
TL;DR: The therapeutic induction of MOMP may restore apoptosis in cancer cells in which it is disabled, and the general rules governing the pathophysiology and controversial issues regarding its regulation are discussed.
Journal ArticleDOI
Two CD95 (APO-1/Fas) signaling pathways
Carsten Scaffidi,Simone Fulda,Anu Srinivasan,Claudia Friesen,Feng Li,Kevin J. Tomaselli,Klaus-Michael Debatin,Peter H. Krammer,Marcus E. Peter +8 more
TL;DR: In the presence of caspase‐3 the amount of active casp enzyme‐8 generated at the DISC determines whether a mitochondria‐independent apoptosis pathway is used (type I cells) or not (type II cells).
Journal Article
The expanding role of mitochondria in apoptosis
TL;DR: The complexity of the apoptotic program began to increase with the discovery of Bcl-2, a gene whose product causes resistance to apoptosis in lymphocytes, and the complex role of mitochondria in apoptosis came into focus when biochemical studies identified several mitochondrial proteins that are able to activate cellular apoptotic programs directly.
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Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
TL;DR: It is concluded that Mfn1 and Mfn2 have both redundant and distinct functions and act in three separate molecular complexes to promote mitochondrial fusion, and by enabling cooperation between mitochondria, has protective effects on the mitochondrial population.