Optogenetic Control of Synaptic AMPA Receptor Endocytosis Reveals Roles of LTD in Motor Learning.
Wataru Kakegawa,Akira Katoh,Sakae Narumi,Eriko Miura,Junko Motohashi,Akiyo Takahashi,Kazuhisa Kohda,Yugo Fukazawa,Michisuke Yuzaki,Shinji Matsuda +9 more
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TLDR
It is shown that fiberoptic illumination to Purkinje cells expressing PhotonSABER in vivo inhibited cerebellar motor learning during adaptation of the horizontal optokinetic response and vestibulo-ocular reflex, as well as synaptic AMPA receptor decrease in the flocculus.About:
This article is published in Neuron.The article was published on 2018-09-05 and is currently open access. It has received 67 citations till now. The article focuses on the topics: AMPA receptor & Synaptic plasticity.read more
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The next generation of approaches to investigate the link between synaptic plasticity and learning.
TL;DR: The authors review the most recent measurement and manipulation approaches that enable links between synaptic plasticity and learning to be examined, and they propose potential future approaches to tackle this endeavor.
Journal ArticleDOI
Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines : Prevalence of Germline Recombination and Influencing Factors
Lin Luo,Mateusz C. Ambrozkiewicz,Fritz Benseler,Cui Chen,Emilie Dumontier,Susanne Falkner,Elisabetta Furlanis,Andrea M. Gomez,Naosuke Hoshina,Wei-Hsiang Huang,Wei-Hsiang Huang,Mary Anne Hutchison,Yu Itoh-Maruoka,Laura A. Lavery,Wei Li,Tomohiko Maruo,Tomohiko Maruo,Tomohiko Maruo,Junko Motohashi,Emily Ling-Lin Pai,Kenneth A. Pelkey,Ariane Pereira,Thomas Philips,Jennifer L. Sinclair,Jeff A. Stogsdill,Jeff A. Stogsdill,Lisa Traunmüller,Jiexin Wang,Joke Wortel,Wenjia You,Nashat Abumaria,Kevin T. Beier,Nils Brose,Harold A. Burgess,Constance L. Cepko,Jean-François Cloutier,Cagla Eroglu,Sandra Goebbels,Pascal S. Kaeser,Jeremy N. Kay,Wei Lu,Liqun Luo,Kenji Mandai,Kenji Mandai,Chris J. McBain,Klaus-Armin Nave,Marco A. M. Prado,Vania F. Prado,Jeffrey D. Rothstein,John L.R. Rubenstein,Gesine Saher,Kenji Sakimura,Joshua R. Sanes,Peter Scheiffele,Yoshimi Takai,Hisashi Umemori,Matthijs Verhage,Michisuke Yuzaki,Huda Y. Zoghbi,Hiroshi Kawabe,Hiroshi Kawabe,Hiroshi Kawabe,Ann Marie Craig +62 more
TL;DR: The prevalence of germline recombination is drawn attention to and guidelines to inform future research for the neuroscience and broader molecular genetics communities are provided.
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Dendritic Spines in Alzheimer's Disease: How the Actin Cytoskeleton Contributes to Synaptic Failure.
TL;DR: The detailed understanding of the mechanisms controlling the actin cytoskeleton in a unique biological context as the dendritic spine could pave the way to the development of innovative synapse-tailored therapeutic interventions and to the identification of novel biomarkers to monitor synaptic loss in AD.
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SK2 channels in cerebellar Purkinje cells contribute to excitability modulation in motor-learning-specific memory traces.
Giorgio Grasselli,Henk-Jan Boele,Heather K. Titley,Nora Bradford,Lisa van Beers,Lindsey Jay,Gerco C. Beekhof,Silas E. Busch,Chris I. De Zeeuw,Chris I. De Zeeuw,Martijn Schonewille,Christian Hansel +11 more
TL;DR: In these mice, the intrinsic plasticity of Purkinje cells is prevented without affecting long-term depression or potentiation at their parallel fiber (PF) input, and SK2 plasticity and excitability modulation are essential for specific forms of motor learning.
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Activity-Dependent Secretion of Synaptic Organizer Cbln1 from Lysosomes in Granule Cell Axons
Keiji Ibata,Maya Kono,Sakae Narumi,Junko Motohashi,Wataru Kakegawa,Kazuhisa Kohda,Michisuke Yuzaki +6 more
TL;DR: It is shown that Cbln1, a synaptic organizer of the C1q family, is released from lysosomes in axons but not dendrites of cerebellar granule cells in an activity- and Ca2+-dependent manner.
References
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