Oral status in patients with early rheumatoid arthritis: a prospective, case–control study
Björn Wolff,Timo Berger,Cornelia Frese,Regina Max,Norbert Blank,Hanns-Martin Lorenz,Diana Wolff +6 more
TLDR
Increased loss of periodontal attachment and alveolar bone can be detected in patients with ERA, therefore it is proposed that the consulting rheumatologists inform the patients that they have a higher risk ofperiodontal disease.Abstract:
Objective. Patients with RA suffer from a higher risk of periodontal attachment loss and increased oral inflammation. We hypothesize that there are pathogenetic and immunological interactions between these diseases that go beyond impaired manual dexterity accompanying advanced RA. The primary objective of the present study was to determine whether a loss of alveolar bone can be detected in RA patients during the early course of the disease. Methods. In this cross-sectional, epidemiological casecontrol study, 22 patients with early RA (ERA) were compared with 22 matched healthy controls. Oral and periodontal status, clinical activity, and sociodemographic parameters were determined. Oral microbiota were analysed using real-time quantitative PCR specific for leading oral pathogens. Results. More advanced forms of periodontitis were found in ERA patients compared with controls. ERA patients had a greater number of missing teeth [ERA 5.7 (S.D. 5.0), controls 1.9 (S.D. 1.0), P = 0.002], deeper periodontal pockets [clinical attachment level: ERA 3.4 (S.D. 0.5 mm), controls 2.7 (S.D. 0.3 mm), P < 0.000], and greater bleeding on probing [ERA 18.6% (S.D. 9.0%), controls 10.5% (S.D. 5.1%), P = 0.001] despite comparable oral hygiene. Tannerella forsythia (6.77-fold, P = 0.033) subgingivally and Streptococcus anginosus (3.56-fold, P = 0.028) supragingivally were the characteristic pathogens in ERA. Conclusion. Increased loss of periodontal attachment and alveolar bone can be detected in patients with ERA, therefore we propose that the consulting rheumatologists inform the patients that they have a higher risk of periodontal disease. It would be beneficial if these patients were referred directly for intensive dental care.read more
Citations
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Microbiota and arthritis: correlations or cause?
TL;DR: The changes occurring in the microbiota in people with arthritis are discussed, and how manipulation of the microbiota may provide an additional pathway for therapy and attempts to ameliorate arthritis by manipulating the microbiota are discussed.
Journal ArticleDOI
Dental treatments, tooth extractions, and osteonecrosis of the jaw in Japanese patients with rheumatoid arthritis: results from the IORRA cohort study
TL;DR: The data suggest that more than a few Japanese patients withRA have dental complications that require care by dentists, and that Japanese rheumatologists and dentists should cooperate to improve dental health in patients with RA.
Journal ArticleDOI
MMP-8 and TIMP-1 are associated to periodontal inflammation in patients with rheumatoid arthritis under methotrexate immunosuppression – First results of a cross-sectional study
Gerhard Schmalz,I. Davarpanah,J. Jäger,Rainer F. Mausberg,Berndt Krohn-Grimberghe,Jana Schmidt,Rainer Haak,U. Sack,Dirk Ziebolz +8 more
TL;DR: periodontal inflammation appears associated to MMP-8 and TIMP-1 in blood in RA patients under methotrexate (MTX) immunosuppression, and clinical interaction between periodontal conditions, periodsontal pathogenic bacteria and RA-related cytokines remain unclear.
Journal ArticleDOI
No Genetic Causal Association Between Periodontitis and Arthritis: A Bidirectional Two-Sample Mendelian Randomization Analysis
TL;DR: The authors' MR analysis reveals non-causal association of PD with arthritis, despite observational studies reporting an association between PD and arthritis.
Journal ArticleDOI
Periodontitis in rheumatoid arthritis patients, abundance and association with disease activity.
TL;DR: About 60% of RA patients suffered fromperiodontitis, but there was not any significant relation between RA disease activity and severity of periodontitis.
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