Oral status in patients with early rheumatoid arthritis: a prospective, case–control study
Björn Wolff,Timo Berger,Cornelia Frese,Regina Max,Norbert Blank,Hanns-Martin Lorenz,Diana Wolff +6 more
TLDR
Increased loss of periodontal attachment and alveolar bone can be detected in patients with ERA, therefore it is proposed that the consulting rheumatologists inform the patients that they have a higher risk ofperiodontal disease.Abstract:
Objective. Patients with RA suffer from a higher risk of periodontal attachment loss and increased oral inflammation. We hypothesize that there are pathogenetic and immunological interactions between these diseases that go beyond impaired manual dexterity accompanying advanced RA. The primary objective of the present study was to determine whether a loss of alveolar bone can be detected in RA patients during the early course of the disease. Methods. In this cross-sectional, epidemiological casecontrol study, 22 patients with early RA (ERA) were compared with 22 matched healthy controls. Oral and periodontal status, clinical activity, and sociodemographic parameters were determined. Oral microbiota were analysed using real-time quantitative PCR specific for leading oral pathogens. Results. More advanced forms of periodontitis were found in ERA patients compared with controls. ERA patients had a greater number of missing teeth [ERA 5.7 (S.D. 5.0), controls 1.9 (S.D. 1.0), P = 0.002], deeper periodontal pockets [clinical attachment level: ERA 3.4 (S.D. 0.5 mm), controls 2.7 (S.D. 0.3 mm), P < 0.000], and greater bleeding on probing [ERA 18.6% (S.D. 9.0%), controls 10.5% (S.D. 5.1%), P = 0.001] despite comparable oral hygiene. Tannerella forsythia (6.77-fold, P = 0.033) subgingivally and Streptococcus anginosus (3.56-fold, P = 0.028) supragingivally were the characteristic pathogens in ERA. Conclusion. Increased loss of periodontal attachment and alveolar bone can be detected in patients with ERA, therefore we propose that the consulting rheumatologists inform the patients that they have a higher risk of periodontal disease. It would be beneficial if these patients were referred directly for intensive dental care.read more
Citations
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Does the microbiota play a role in the pathogenesis of autoimmune diseases
TL;DR: This review summarises the current status on the role of the microbiota in autoimmune diseases and offers novel insight into factors that initiate and drive disease progression, stratify patient risk for complications and ultimately deliver new therapeutic strategies.
Journal ArticleDOI
Hand to Mouth: A Systematic Review and Meta-Analysis of the Association between Rheumatoid Arthritis and Periodontitis.
TL;DR: A significant association between RA and periodontitis is supported by the results of the systematic review and meta-analysis of studies comparing RA to healthy controls and this is not replicated when comparingRA to OA controls.
Journal ArticleDOI
Integration of microbiome and epigenome to decipher the pathogenesis of autoimmune diseases.
Bei-di Chen,Luxi Sun,Xuan Zhang +2 more
TL;DR: Dysbiosis was detected in the gut and oral microbiomes of RA patients, but it was partially restored after treatment, and functional changes of microbiota and molecular mimicry of human antigens in RA individuals were found.
Journal ArticleDOI
Relationship between Periodontitis and Rheumatoid Arthritis: Review of the Literature.
TL;DR: The majority of the articles have confirmed that there is a correlation between PD and RA, since both disorders have characteristics in common and result from an imbalance in the immunoinflammatory response.
Journal ArticleDOI
How the microbiota shapes rheumatic diseases.
Tom Van de Wiele,Jens Van Praet,Jens Van Praet,Massimo Marzorati,Michael B. Drennan,Michael B. Drennan,Dirk Elewaut,Dirk Elewaut +7 more
TL;DR: The role of the gut microbiota in shaping local and systemic immune responses and how disturbances in the host–microorganism interplay can potentially affect the development and progression of rheumatic diseases are reviewed.
References
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Journal ArticleDOI
Periodontitis in established rheumatoid arthritis patients: A cross-sectional clinical, microbiological and serological study
Menke J. de Smit,Johanna Westra,Arjan Vissink,Berber Doornbos-van der Meer,Elisabeth Brouwer,Arie Jan van Winkelhoff +5 more
TL;DR: Severity of periodontitis is related to severity of RA, and RA patients with severeperiodontitis have a more robust antibody response against P. gingivalis than non-RA controls, but not all RA patients have cultivable P. rheumatoid arthritis.
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Studies on Dental Caries: XII. Comparison of the Caries Susceptibility of the Various Morphological Types of Permanent Teeth
Henry Klein,Carroll E. Palmer +1 more
TL;DR: Values for this variable, which has been designated by the term "posteruptive tooth age" have recently been obtained and are used in the present study to identify and compare the orders of susceptibility of the different morphological types of permanent teeth.
Journal ArticleDOI
Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance in rheumatoid arthritis.
Anne-Marie Quirke,Elena B. Lugli,Natalia Wegner,Bart C. Hamilton,Peter Charles,Muslima Chowdhury,A. Jimmy Ytterberg,Roman A. Zubarev,Jan Potempa,Jan Potempa,Shauna Culshaw,Yonghua Guo,Benjamin A Fisher,Geoffrey M. Thiele,Ted R. Mikuls,Patrick J Venables +15 more
TL;DR: The peptidyl citrulline-specific immune response to PPAD supports the hypothesis that, as a bacterial protein, it might break tolerance in RA, and could be a target for therapy.
Journal ArticleDOI
Anti-Tumor Necrosis Factor-Alpha Therapy and Periodontal Parameters in Patients With Rheumatoid Arthritis
TL;DR: Patients with rheumatoid arthritis receiving anti-TNF-alpha medication had lower periodontal indices and GCF TNF- alpha levels, suggesting suppression of proinflammatory cytokines might prove beneficial in suppressingperiodontal diseases.
Journal ArticleDOI
Aggregatibacter actinomycetemcomitans builds mutualistic biofilm communities with Fusobacterium nucleatum and Veillonella species in saliva
TL;DR: It is proposed that mutualistic two-species and multispecies oral biofilm communities form in vivo and that mutualism between commensal veillonellae and late colonizing pathogens, such as aggregatibacteria, contributes to the development of periodontal disease.
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