Oral status in patients with early rheumatoid arthritis: a prospective, case–control study
Björn Wolff,Timo Berger,Cornelia Frese,Regina Max,Norbert Blank,Hanns-Martin Lorenz,Diana Wolff +6 more
TLDR
Increased loss of periodontal attachment and alveolar bone can be detected in patients with ERA, therefore it is proposed that the consulting rheumatologists inform the patients that they have a higher risk ofperiodontal disease.Abstract:
Objective. Patients with RA suffer from a higher risk of periodontal attachment loss and increased oral inflammation. We hypothesize that there are pathogenetic and immunological interactions between these diseases that go beyond impaired manual dexterity accompanying advanced RA. The primary objective of the present study was to determine whether a loss of alveolar bone can be detected in RA patients during the early course of the disease. Methods. In this cross-sectional, epidemiological casecontrol study, 22 patients with early RA (ERA) were compared with 22 matched healthy controls. Oral and periodontal status, clinical activity, and sociodemographic parameters were determined. Oral microbiota were analysed using real-time quantitative PCR specific for leading oral pathogens. Results. More advanced forms of periodontitis were found in ERA patients compared with controls. ERA patients had a greater number of missing teeth [ERA 5.7 (S.D. 5.0), controls 1.9 (S.D. 1.0), P = 0.002], deeper periodontal pockets [clinical attachment level: ERA 3.4 (S.D. 0.5 mm), controls 2.7 (S.D. 0.3 mm), P < 0.000], and greater bleeding on probing [ERA 18.6% (S.D. 9.0%), controls 10.5% (S.D. 5.1%), P = 0.001] despite comparable oral hygiene. Tannerella forsythia (6.77-fold, P = 0.033) subgingivally and Streptococcus anginosus (3.56-fold, P = 0.028) supragingivally were the characteristic pathogens in ERA. Conclusion. Increased loss of periodontal attachment and alveolar bone can be detected in patients with ERA, therefore we propose that the consulting rheumatologists inform the patients that they have a higher risk of periodontal disease. It would be beneficial if these patients were referred directly for intensive dental care.read more
Citations
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Periodontal disease and subgingival microbiota as contributors for rheumatoid arthritis pathogenesis: modifiable risk factors?
TL;DR: Smoking and periodontal disease are emerging risk factors for the development of RA and epidemiological, clinical, and basic research has further strengthened this association.
Journal ArticleDOI
Periodontitis in early and chronic rheumatoid arthritis: a prospective follow-up study in Finnish population
Leena Äyräväinen,Marjatta Leirisalo-Repo,Antti Kuuliala,Kirsi Ahola,Riitta Koivuniemi,Jukka H. Meurman,Anna Maria Heikkinen +6 more
TL;DR: Moderate periodontitis was more frequent in patients with RA than in controls, and patients with ERA and CRA exhibited poorer periodontal health parameters when compared with controls.
Journal ArticleDOI
Periodontal Disease in Individuals With a Genetic Risk of Developing Arthritis and Early Rheumatoid Arthritis: A Cross-Sectional Study
Juan Manuel Bello-Gualtero,Gloria Inés Lafaurie,Lida X. Hoyos,Diana Marcela Castillo,Juliette De-Avila,Juan Carlos Munevar,Sonia Unriza,John Londoño,Rafael Valle-Oñate,Rafael Valle-Oñate,Consuelo Romero-Sánchez,Consuelo Romero-Sánchez,Consuelo Romero-Sánchez +12 more
TL;DR: This study shows that individuals with pre-RA have significant inflammatory periodontal involvement and markers of RA activity in individuals with eRA.
Journal ArticleDOI
Periodontitis and Rheumatoid Arthritis: The Same Inflammatory Mediators?
Fulvia Ceccarelli,Matteo Saccucci,Gabriele Di Carlo,Ramona Lucchetti,Andrea Pilloni,Nicola Pranno,Valeria Luzzi,Guido Valesini,Antonella Polimeni +8 more
TL;DR: Data from literature demonstrated the association between HLA-DRB1 alleles and PD susceptibility, similar to RA patients, and SE-positive patients showed simultaneously structural damage to the wrist and periodontal sites, suggesting the need to perform further studies to better define this issue.
Journal ArticleDOI
Cross-Sectional Evaluation of Periodontal Status and Microbiologic and Rheumatoid Parameters in a Large Cohort of Patients With Rheumatoid Arthritis.
Jan Schmickler,Annegret Rupprecht,Susann Patschan,Daniel Patschan,Gerhard A. Müller,Rainer Haak,Rainer F. Mausberg,Gerhard Schmalz,Tanja Kottmann,Dirk Ziebolz +9 more
TL;DR: Although a trend for higher F. nucleatum and P. gingivalis concentrations in aCCP-positive patients with RA was found, importance of periodontal pathogenic bacteria and rheumatoid parameters in the interrelationship between periodontitis and RA remains unclear.
References
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