Overview of the yeast genome
Hans-Werner Mewes,Kaj Albermann,Manuel Bahr,Dmitrij Frishman,A. Gleissner,Jean Hani,Klaus Heumann,K. Kleine,Andreas Maierl,Stephen G. Oliver,Friedhelm Pfeiffer,Alfred Zollner +11 more
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TLDR
The first complete set of genes from a eukaryotic organism, the Saccharomyces cerevisiae genome, was sequenced by more than 600 scientists from over 100 laboratories.Abstract:
The collaboration of more than 600 scientists from over 100 laboratories to sequence the Saccharomyces cerevisiae genome was the largest decentralised experiment in modern molecular biology and resulted in a unique data resource representing the first complete set of genes from a eukaryotic organism. 12 million bases were sequenced in a truly international effort involving European, US, Canadian and Japanese laboratories. While the yeast genome represents only a small fraction of the information in today's public sequence databases, the complete, ordered and non-redundant sequence provides an invaluable resource for the detailed analysis of cellular gene function and genome architecture. In terms of throughput, completeness and information content, yeast has always been the lead eukaryotic organism in genomics; it is still the largest genome to be completely sequenced.read more
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Analysis of the genome sequence of the flowering plant Arabidopsis thaliana.
TL;DR: This is the first complete genome sequence of a plant and provides the foundations for more comprehensive comparison of conserved processes in all eukaryotes, identifying a wide range of plant-specific gene functions and establishing rapid systematic ways to identify genes for crop improvement.
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A genomic perspective on protein families
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Systematic determination of genetic network architecture
TL;DR: A systematic set of statistical algorithms are applied, based on whole-genome mRNA data, partitional clustering and motif discovery, to identify transcriptional regulatory sub-networks in yeast—without any a priori knowledge of their structure or any assumptions about their dynamics.
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The WRKY superfamily of plant transcription factors
TL;DR: The WRKY proteins are a superfamily of transcription factors with up to 100 representatives in Arabidopsis that appear to be involved in the regulation of various physio-logical programs that are unique to plants, including pathogen defense, senescence and trichome development.
Journal ArticleDOI
Proof and evolutionary analysis of ancient genome duplication in the yeast Saccharomyces cerevisiae
TL;DR: It is shown that the yeast Saccharomyces cerevisiae arose from ancient whole-genome duplication, by sequencing and analysing Kluyveromyces waltii, a related yeast species that diverged before the duplication.
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