Participation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinase
Shaoning Jiang,Dae Won Park,Dae Won Park,Yong Gao,Saranya Ravi,Victor M. Darley-Usmar,Edward Abraham,Jaroslaw W. Zmijewski +7 more
TLDR
The results indicate that accumulation of ubiquitinated proteins alter cellular bioenergetics and redox status, leading to AMPK activation.About:
This article is published in Cellular Signalling.The article was published on 2015-06-01 and is currently open access. It has received 37 citations till now. The article focuses on the topics: AMPK & MG132.read more
Citations
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Journal ArticleDOI
Proteasomal and Autophagic Degradation Systems.
TL;DR: This review summarizes molecular details of how proteasome and autophagy pathways are functionally interconnected in cells and indicates common principles and nodes of communication that can be therapeutically exploited.
Journal ArticleDOI
AMPK in skeletal muscle function and metabolism.
Rasmus Kjøbsted,Janne R. Hingst,Joachim Fentz,Marc Foretz,Marc Foretz,Marc Foretz,Maria Nieves Sanz,Christian Pehmøller,Michael Shum,André Marette,Rémi Mounier,Jonas T. Treebak,Jørgen F. P. Wojtaszewski,Benoit Viollet,Benoit Viollet,Benoit Viollet,Louise Lantier +16 more
TL;DR: The role of AMPK in skeletal muscle during exercise and in exercise recovery is focused on and adaptations to exercise training, including skeletal muscle plasticity, are addressed, highlighting novel concepts and future perspectives that need to be investigated.
Journal ArticleDOI
Crosstalk Between Mammalian Autophagy and the Ubiquitin-Proteasome System.
TL;DR: This review summarizes direct and indirect interactions and crosstalks between autophagy and the UPS, and their implications for cellular stress responses and homeostasis.
A central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders
TL;DR: It is shown in mice that muscle-specific mitsugumin 53 mediates the degradation of the insulin receptor and insulin receptor substrate 1 (IRS1), and when upregulated, causes metabolic syndrome featuring insulin resistance, obesity, hypertension and dyslipidaemia.
References
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
TL;DR: A molecular mechanism for regulation of the mammalian autophagy-initiating kinase Ulk1, a homologue of yeast ATG1, is demonstrated and a signalling mechanism for UlK1 regulation and autophagic induction in response to nutrient signalling is revealed.
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The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction
TL;DR: It is clear now that degradation of cellular proteins is a highly complex, temporally controlled, and tightly regulated process that plays major roles in a variety of basic pathways during cell life and death as well as in health and disease.
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AMPK: a nutrient and energy sensor that maintains energy homeostasis
TL;DR: AMP-activated protein kinase conserves ATP levels through the regulation of processes other than metabolism, such as the cell cycle and neuronal membrane excitability.
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AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism
TL;DR: Through signaling, metabolic, and gene expression effects, AMPK enhances insulin sensitivity and fosters a metabolic milieu that may reduce the risk for obesity and type 2 diabetes.
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Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy
Daniel F. Egan,David B. Shackelford,Maria M. Mihaylova,Sara Gelino,Rebecca A. Kohnz,William B. Mair,Debbie S. Vasquez,Aashish Joshi,Dana M. Gwinn,Rebecca C. Taylor,John M. Asara,James A. J. Fitzpatrick,Andrew Dillin,Benoit Viollet,Mondira Kundu,Malene Hansen,Reuben J. Shaw +16 more
TL;DR: Reconstitution of ULK1-deficient cells with a mutant ULK2 that cannot be phosphorylated by AMPK revealed that such phosphorylation is required for mitochondrial homeostasis and cell survival during starvation.