Persistence of Anti-SARS-CoV-2 Antibodies Depends on the Analytical Kit: A Report for Up to 10 Months after Infection.
Julien Favresse,Christine Eucher,Marc Elsen,Constant Gillot,Sandrine Van Eeckhoudt,Jean-Michel Dogné,Jonathan Douxfils +6 more
- Vol. 9, Iss: 3, pp 556
TLDR
In this article, the authors explore the temporal dynamic changes of the immune response after SARS-CoV-2 infection in hospitalized and non-hospitalized symptomatic patients over a period of 10 months.Abstract:
Several studies have described the long-term kinetics of anti-SARS-CoV-2 antibodies but long-term follow-up data, i.e., >6 months, are still sparse. Additionally, the literature is inconsistent regarding the waning effect of the serological response. The aim of this study was to explore the temporal dynamic changes of the immune response after SARS-CoV-2 infection in hospitalized and non-hospitalized symptomatic patients over a period of 10 months. Six different analytical kits for SARS-CoV-2 antibody detection were used. Positivity rates, inter-assay agreement and kinetic models were determined. A high inter-individual and an inter-methodology variability was observed. Assays targeting total antibodies presented higher positivity rates and reached the highest positivity rates sooner compared with assays directed against IgG. The inter-assay agreement was also higher between these assays. The stratification by disease severity showed a much-elevated serological response in hospitalized versus non-hospitalized patients in all assays. In this 10-month follow-up study, serological assays showed a clinically significant difference to detect past SARS-CoV-2 infection with total antibody assays presenting the highest positivity rates. The waning effect reported in several studies should be interpreted with caution because it could depend on the assay considered.read more
Citations
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Journal ArticleDOI
Antibody titres decline 3-month post-vaccination with BNT162b2.
Julien Favresse,Jean-Louis Bayart,François Mullier,Marc Elsen,Christine Eucher,Sandrine Van Eeckhoudt,Tatiana Roy,Grégoire Wieërs,Christine Laurent,Jean-Michel Dogné,Mélanie Closset,Jonathan Douxfils +11 more
TL;DR: In this paper, the authors reported on the humoral response in subjects having received the BNT162b2 mRNA COVID-19 vaccine, but no data on the kinetics of antibodies 3 months post-vaccination are currently available.
Journal ArticleDOI
Waning of IgG, Total and Neutralizing Antibodies 6 Months Post-Vaccination with BNT162b2 in Healthcare Workers.
Jean-Louis Bayart,Jonathan Douxfils,Constant Gillot,Clara David,François Mullier,Marc Elsen,Christine Eucher,Sandrine Van Eeckhoudt,Tatiana Roy,Vincent Gerin,Grégoire Wieërs,Christine Laurent,Mélanie Closset,Jean-Michel Dogné,Julien Favresse +14 more
TL;DR: The antibody decline observed in a population of COVID-19 naïve and CO VID-19 positive individuals having received the two dose regimen of the BNT162b2 vaccine six months after vaccination is reported.
Journal ArticleDOI
Neutralizing Antibodies in COVID-19 Patients and Vaccine Recipients after Two Doses of BNT162b2.
Julien Favresse,Constant Gillot,Laura Di Chiaro,Christine Eucher,Marc Elsen,Sandrine Van Eeckhoudt,Clara David,Laure Morimont,Jean-Michel Dogné,Jonathan Douxfils +9 more
TL;DR: The neutralizing antibodies (NAbs) in COVID-19 patients and in vaccinated individuals were measured and compared to six different SARS-CoV-2 serology assays and the agreement between the sVNT and pseudovirus VNT (pVNT) results was found to be excellent.
Journal ArticleDOI
Early antibody response in health-care professionals after two doses of SARS-CoV-2 mRNA vaccine (BNT162b2).
Julien Favresse,Jean-Louis Bayart,François Mullier,Jean-Michel Dogné,Mélanie Closset,Jonathan Douxfils +5 more
TL;DR: The CRO-VAX HCP study as discussed by the authors investigated the early antibody response in a population of health-care professionals having received two doses of the BNT162b2 mRNA coronavirus disease 2019 (COVID-19) vaccine.
Journal ArticleDOI
Analytical and clinical performances of a SARS-CoV-2 S-RBD IgG assay: comparison with neutralization titers.
Andrea Padoan,Francesco Bonfante,Chiara Cosma,Costanza Di Chiara,Laura Sciacovelli,Matteo Pagliari,Alessio Bortolami,Paola Costenaro,Giulia Musso,Daniela Basso,Carlo Giaquinto,Mario Plebani +11 more
TL;DR: SARS-CoV-2 S-RBD IgG assay achieves elevated analytical and clinical performances, and a strong correlation with sera neutralization activity, and is effective in understanding the virus epidemiology and vaccine prioritization strategies.
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TL;DR: ChAdOx1 nCoV-19 has an acceptable safety profile and has been found to be efficacious against symptomatic COVID-19 in this interim analysis of ongoing clinical trials.
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TL;DR: The serial respiratory viral load of SARS-CoV-2 in posterior oropharyngeal saliva samples from patients with COVID-19, and serum antibody responses from patients infected with severe acute respiratory syndrome coronavirus 2 are ascertained.
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