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Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013

A. Goldhirsch, +57 more
- 01 Sep 2013 - 
- Vol. 24, Iss: 9, pp 2206-2223
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TLDR
The 13th St Gallen International Breast Cancer Conference (2013) Expert Panel reviewed and endorsed substantial new evidence on aspects of the local and regional therapies for early breast cancer, supporting less extensive surgery to the axilla and shorter durations of radiation therapy.
About: 
This article is published in Annals of Oncology.The article was published on 2013-09-01 and is currently open access. It has received 2831 citations till now. The article focuses on the topics: Breast cancer & Adjuvant therapy.

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Journal ArticleDOI

A New Challenge for Radiologists: Radiomics in Breast Cancer

Paola Crivelli, +5 more
- 08 Oct 2018 - 
TL;DR: The role of radiomics in breast cancer is assessed, focusing on the ability of the diagnostic tool to predict malignancy, response to neoadjuvant chemotherapy, prognostic factors, molecular subtypes, and risk of recurrence.
Journal ArticleDOI

Mutational profiles in triple-negative breast cancer defined by ultradeep multigene sequencing show high rates of PI3K pathway alterations and clinically relevant entity subgroup specific differences.

Mark Kriegsmann, +10 more
- 16 Sep 2014 - 
TL;DR: A breast cancer specific gene panel for semiconductor-based sequencing comprising 137 amplicons covering mutational hotspots in 44 genes is designed and validated and could demonstrate that breast cancer targeted hotspot sequencing is feasible in a routine setting and yields reliable and clinically meaningful results.
Journal ArticleDOI

Transfer of clinically relevant gene expression signatures in breast cancer: from Affymetrix microarray to Illumina RNA-Sequencing technology

Debora Fumagalli, +17 more
- 21 Nov 2014 - 
TL;DR: This is the first study to report a systematic comparison of RNA-Seq to microarray for the evaluation of single genes and GES clinically relevant to BC and finds the vast majority of single gene biomarkers and well-established GES can be reliably evaluated using the RNA- Seq technology.
Journal ArticleDOI

Lack of G protein-coupled estrogen receptor (GPER) in the plasma membrane is associated with excellent long-term prognosis in breast cancer

Martin Sjöström, +10 more
- 09 Apr 2014 - 
TL;DR: GPER overexpression and PM localization are critical events in breast cancer progression, and lack of GPER in the PM is associated with excellent long-term prognosis in ER-positive and PgR-positive tamoxifen-treated primary breast cancer.
Journal ArticleDOI

Invasive lobular breast cancer and its variants: How special are they for systemic therapy decisions?

Séverine Guiu, +6 more
- 01 Dec 2014 - 
TL;DR: There is a need for improving clinical research design to allow oncologists to make informed systemic therapy decisions in patients with ILC, and future studies should compare various endpoints in ILC breast cancer patients among the group of hormonosensitive breast cancer.
References
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Journal ArticleDOI

Comprehensive molecular portraits of human breast tumours

Daniel C. Koboldt, +355 more
- 04 Oct 2012 - 
TL;DR: The ability to integrate information across platforms provided key insights into previously defined gene expression subtypes and demonstrated the existence of four main breast cancer classes when combining data from five platforms, each of which shows significant molecular heterogeneity.
Journal ArticleDOI

Comprehensive molecular portraits of human breast tumours

A. McCullough
- 01 Jan 2013 - 
Journal ArticleDOI

Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes

Joel S. Parker, +19 more
- 10 Mar 2009 - 
TL;DR: D diagnosis by intrinsic subtype adds significant prognostic and predictive information to standard parameters for patients with breast cancer.
Journal ArticleDOI

Strategies for subtypes—dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011

A. Goldhirsch, +5 more
- 01 Aug 2011 - 
TL;DR: Broad treatment recommendations are presented, recognizing that detailed treatment decisions need to consider disease extent, host factors, patient preferences, and social and economic constraints.
Journal ArticleDOI

Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: A randomized clinical trial

Armando E. Giuliano, +9 more
- 09 Feb 2011 - 
TL;DR: Among patients with limited SLN metastatic breast cancer treated with breast conservation and systemic therapy, the use of SLND alone compared with ALND did not result in inferior survival, and overall survival was the primary end point, with a noninferiority margin of a 1-sided hazard ratio of less than 1.3 indicating thatSLND alone is noninherited.
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