Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013
A. Goldhirsch,E P Winer,A S Coates,R. D. Gelber,M Piccart-Gebhart,B. Thürlimann,H.-J. Senn,Kathy S. Albain,Fabrice Andre,Jonas Bergh,Hervé Bonnefoi,Denisse Bretel-Morales,Harold J. Burstein,Fatima Cardoso,M. Castiglione-Gertsch,Alan S. Coates,Marco Colleoni,Alberto Costa,Giuseppe Curigliano,Nancy E. Davidson,Angelo Di Leo,Bent Ejlertsen,John F. Forbes,Richard D. Gelber,Michael Gnant,Aron Goldhirsch,Pamela J. Goodwin,Paul E. Goss,Jay R. Harris,Daniel F. Hayes,Clifford A. Hudis,James N. Ingle,Jacek Jassem,Zefei Jiang,Per Karlsson,Sibylle Loibl,Monica Morrow,Moïse Namer,C. Kent Osborne,Ann H. Partridge,Frédérique Penault-Llorca,Charles M. Perou,Martine Piccart-Gebhart,Kathleen I. Pritchard,Emiel J. Th. Rutgers,Felix Sedlmayer,Vladimir Semiglazov,Z Shao,Ian E. Smith,Beat Thürlimann,Masakazu Toi,Andrew Tutt,Michael Untch,Giuseppe Viale,Toru Watanabe,Nicholas Wilcken,Eric P. Winer,William C. Wood +57 more
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TLDR
The 13th St Gallen International Breast Cancer Conference (2013) Expert Panel reviewed and endorsed substantial new evidence on aspects of the local and regional therapies for early breast cancer, supporting less extensive surgery to the axilla and shorter durations of radiation therapy.About:
This article is published in Annals of Oncology.The article was published on 2013-09-01 and is currently open access. It has received 2831 citations till now. The article focuses on the topics: Breast cancer & Adjuvant therapy.read more
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Expression of Gastrin-Releasing Peptide Receptor in Breast Cancer and Its Association with Pathologic, Biologic, and Clinical Parameters: A Study of 1,432 Primary Tumors.
Clément Morgat,Gaëtan MacGrogan,Véronique Brouste,Valérie Vélasco,Nicolas Sevenet,Hervé Bonnefoi,Philippe Fernandez,Marc Debled,Elif Hindié +8 more
TL;DR: Because GRPR is overexpressed in a high percentage of ER- positive tumors, GRPR targeting offers wide perspectives for imaging and treatment in patients with ER-positive breast cancer, using recently developed radiolabeled GRPR ligands.
Journal ArticleDOI
Circulating MicroRNAs as easy-to-measure aging biomarkers in older breast cancer patients: Correlation with chronological age but not with fitness/frailty status
Sigrid Hatse,Barbara Brouwers,Bruna Dalmasso,Annouschka Laenen,Cindy Kenis,Patrick Schöffski,Hans Wildiers +6 more
TL;DR: Interestingly, the age-associated miRNAs did not show differential expression between fit/healthy and non-fit/frail subjects within the older breast cancer cohort of the validation study and thus merit further investigation as true aging markers that not merely reflect frailty.
Journal ArticleDOI
MCM2, MCM4, and MCM6 in Breast Cancer: Clinical Utility in Diagnosis and Prognosis.
TL;DR: A positive relationship exists among the three scoring methods of each of the four markers of Minichromosome Maintenance, which can help in distinction between luminal A and luminal B whose therapeutic management and clinical outcomes are different.
Journal ArticleDOI
P53 and Ki-67 as prognostic markers in triple-negative breast cancer patients
TL;DR: It is suggested that p53, Ki-67 and family history are useful prognostic markers in TNBC, and the tumor size, lymph node involvement, and p53 expression are associated with risk of recurrence.
Journal ArticleDOI
The branched-chain amino acid transaminase 1 sustains growth of antiestrogen-resistant and ERα-negative breast cancer.
Verena Thewes,Ronald Simon,Mario Hlevnjak,Magdalena Schlotter,Petra Schroeter,Kathrin V. Schmidt,Yonghe Wu,Tobias Anzeneder,Wei Wang,P. Windisch,M. Kirchgäßner,Nathaniel Melling,Niclas Kneisel,Reinhard Büttner,Ulrich Deuschle,Hans-Peter Sinn,Andreas Schneeweiss,Stefanie Heck,S. Kaulfuss,H. Hess-Stumpp,Jürgen G. Okun,Guido Sauter,A. E. Lykkesfeldt,Marc Zapatka,Bernhard Radlwimmer,Peter Lichter,Martje Tönjes +26 more
TL;DR: Silencing of BCAT1 in an orthotopic triple-negative xenograft model resulted in a massive reduction of tumor volume in vivo, supporting the findings thatBCAT1 is necessary for the growth of hormone-independent breast tumors.
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Supervised Risk Predictor of Breast Cancer Based on Intrinsic Subtypes
Joel S. Parker,Michael Mullins,Maggie C.U. Cheang,Samuel Leung,David Voduc,Tammi L. Vickery,Sherri R. Davies,Christiane Fauron,Xiaping He,Zhiyuan Hu,John Quackenbush,Inge J. Stijleman,Juan P. Palazzo,James Stephen Marron,Andrew B. Nobel,Elaine R. Mardis,Torsten O. Nielsen,Matthew J. Ellis,Charles M. Perou,Philip S. Bernard +19 more
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Strategies for subtypes—dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011
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Axillary dissection vs no axillary dissection in women with invasive breast cancer and sentinel node metastasis: A randomized clinical trial
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