Journal ArticleDOI
Physiological Pathways Regulating the Activity of Magnocellular Neurosecretory Cells
TLDR
This review considers the rôle played by particular afferent pathways in the regulation of the activity of oxytocin and vasopressin cells.About:
This article is published in Progress in Neurobiology.The article was published on 1999-04-01. It has received 307 citations till now. The article focuses on the topics: Vasopressin & Oxytocin.read more
Citations
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Journal ArticleDOI
The Oxytocin Receptor System: Structure, Function, and Regulation
Gerald Gimpl,Falk Fahrenholz +1 more
TL;DR: The regulation by gonadal and adrenal steroids is one of the most remarkable features of the OT system and is, unfortunately, the least understood.
Journal ArticleDOI
Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication
Rainer Landgraf,Inga D. Neumann +1 more
TL;DR: This concept considers neuropeptides in the extracellular fluid of the brain rather than those in the cerebrospinal fluid or plasma as primary signals, triggering a variety of receptor-mediated effects, including those underlying behavioral and neuroendocrine regulation and psychopathology.
Journal ArticleDOI
Dendritic peptide release and peptide-dependent behaviours
Mike Ludwig,Gareth Leng +1 more
TL;DR: The recently demonstrated ability of neuropeptides to prime vesicle stores for activity-dependent release could lead to a temporary functional reorganization of neuronal networks harbouring specific peptide receptors, providing a substrate for long-lasting effects.
Journal ArticleDOI
Physiology of Vasopressin Relevant to Management of Septic Shock
TL;DR: Clinical use of vasopressin should await a randomized controlled trial of its effects on clinical outcomes such as organ failure and mortality, because clinical studies have been relatively small, focused on physiologic end points, and because of potential adverse effects of vasipressin.
Journal ArticleDOI
The hypothalamic-neurohypophysial system regulates the hypothalamic-pituitary-adrenal axis under stress: an old concept revisited.
TL;DR: Data supporting the concept of HNS effects on HPA axis activity is presented and their possible impact on some aspects of behavioural regulation and psychopathology is outlined.
References
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Journal ArticleDOI
Ablation of the region anterior and ventral to the third ventricle (AV3V region) in the rat does not abolish the release of oxytocin in response to systemic cholecystokinin
R.E. Blackburn,G. Leng +1 more
TL;DR: CCK8 evoked a repeatable and dose-dependent release of oxytocin, but not vasopressin, into the systemic circulation of both sham and lesioned rats, confirming that in the rat CCK8 is a selective stimulus for Oxytocin release and showing that this release is not significantly impaired by lesions of the AV3V region.
Journal ArticleDOI
Intracellular calcium and hormone release from nerve endings of the neurohypophysis in the presence of opioid agonists and antagonists.
TL;DR: It is doubtful that opioid molecules have a physiological role in controlling neurohypophysial secretion and a number of inconsistencies exist between the effects of opioid agonists and antagonists on neuropeptide release and on the evoked changes in [Ca2+]i.
Journal ArticleDOI
Antidiuretic Effects of ATP Induced by Microinjection into the Hypothalamic Supraoptic Nucleus in Water-Loaded and Ethanol-Anesthetized Rats
TL;DR: It is suggested that ATP injected into the SON has antidiuretic effects due to release of AVP through an activation of theophylline-sensitive purinoceptors, and not adenosine triphosphate, which concentration-dependent decreased the urine outflow with concomitant increase in the urine osmotic pressure.
Journal ArticleDOI
The afferent pathway for carotid body chemoreceptor input to the hypothalamic supraoptic nucleus in the rat.
TL;DR: The pathway for chemoreceptor input to hypothalamic supraoptic nuclei has been examined in anaesthetised lactating and non-lactating rats and the possible significance of vasopressin in the control of arterial blood pressure is discussed.
Journal ArticleDOI
Electron-Microscopic Immunocytochemistry of Neuropeptide Y Immunoreactive Innervation of Vasopressin Neurons in the Paraventricular Nucleus of the Rat Hypothalamus
TL;DR: The neuropeptide Y (NPY) immunoreactive synaptic input to neurons containing neurophysin II (NP II), the carrier protein of vasopressin (VP), was observed in the paraventricular nucleus of the rat hypothalamus by double-labeling immunocytochemistry.
Related Papers (5)
Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis.
David V. Pow,John F. Morris +1 more