Journal ArticleDOI
Physiological Pathways Regulating the Activity of Magnocellular Neurosecretory Cells
TLDR
This review considers the rôle played by particular afferent pathways in the regulation of the activity of oxytocin and vasopressin cells.About:
This article is published in Progress in Neurobiology.The article was published on 1999-04-01. It has received 307 citations till now. The article focuses on the topics: Vasopressin & Oxytocin.read more
Citations
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Journal ArticleDOI
The Oxytocin Receptor System: Structure, Function, and Regulation
Gerald Gimpl,Falk Fahrenholz +1 more
TL;DR: The regulation by gonadal and adrenal steroids is one of the most remarkable features of the OT system and is, unfortunately, the least understood.
Journal ArticleDOI
Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication
Rainer Landgraf,Inga D. Neumann +1 more
TL;DR: This concept considers neuropeptides in the extracellular fluid of the brain rather than those in the cerebrospinal fluid or plasma as primary signals, triggering a variety of receptor-mediated effects, including those underlying behavioral and neuroendocrine regulation and psychopathology.
Journal ArticleDOI
Dendritic peptide release and peptide-dependent behaviours
Mike Ludwig,Gareth Leng +1 more
TL;DR: The recently demonstrated ability of neuropeptides to prime vesicle stores for activity-dependent release could lead to a temporary functional reorganization of neuronal networks harbouring specific peptide receptors, providing a substrate for long-lasting effects.
Journal ArticleDOI
Physiology of Vasopressin Relevant to Management of Septic Shock
TL;DR: Clinical use of vasopressin should await a randomized controlled trial of its effects on clinical outcomes such as organ failure and mortality, because clinical studies have been relatively small, focused on physiologic end points, and because of potential adverse effects of vasipressin.
Journal ArticleDOI
The hypothalamic-neurohypophysial system regulates the hypothalamic-pituitary-adrenal axis under stress: an old concept revisited.
TL;DR: Data supporting the concept of HNS effects on HPA axis activity is presented and their possible impact on some aspects of behavioural regulation and psychopathology is outlined.
References
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Journal ArticleDOI
Paired recordings from supraoptic and paraventricular oxytocin cells in suckled rats: recruitment and synchronization.
TL;DR: Oxytocin cells in the paraventricular (p.v.) and contralateral supraoptic (s.o.) nuclei were pair‐recorded in suckled rats after being anaesthetized with urethane to study the synchronization of their neurosecretory bursts, the importance of cell recruitment and their firing characteristics.
Journal ArticleDOI
Control of release of vasopressin by neuroendocrine reflexes.
G. W. Bisset,H. S. Chowdrey +1 more
TL;DR: The neurones in the supraoptic and paraventricular nuclei (SON and PVN) are separate from those which secrete oxytocin and are distributed in different parts of the nuclei and suggest an excitatory, rather than inhibitory, function of the A1 noradrenergic neurones involving alpha 1-receptors.
Journal ArticleDOI
Extracellular recordings from oxytocin neurones during the expulsive phase of birth in unanaesthetized rats.
TL;DR: Neuronal activity was correlated with the observed events of parturition, i.e. abdominal contractions and delivery of young or placentae, and potential vasopressin‐producing cells were classified as oxytocinergic on the basis of their stereotyped activation before reflex milk‐ejection.
Journal ArticleDOI
Sex, parturition and motherhood without oxytocin?
John A. Russell,Gareth Leng +1 more
TL;DR: In both types of oxytocin gene disablement, the only evident defect was a complete failure of postpartum homozygotes to transfer milk to the suckling young, which consequently did not survive unless the mothers were treated with exogenous oxytocIn, and these findings are surprising in view of the vast literature on a wide range of species suggesting important roles for oxytoc in regulating gonadal function, in expression of sexual behaviour, in parturition and initiation of maternal behaviour as well as
Journal ArticleDOI
The distribution and cells of origin of ACTH(1-39)-stained varicosities in the paraventricular and supraoptic nuclei.
P.E. Sawchenko,P.E. Sawchenko,Larry W. Swanson,Larry W. Swanson,Shirley A. Joseph,Shirley A. Joseph +5 more
TL;DR: A combined retrograde transport-immunohistochemical method was used to confirm that these projections arise from a group of ACTH(1-39)-stained cells in the arcuate nucleus (and in adjacent regions along the base of the hypothalamus), and to describe their distribution within this region.
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Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis.
David V. Pow,John F. Morris +1 more