Journal ArticleDOI
Physiological Pathways Regulating the Activity of Magnocellular Neurosecretory Cells
TLDR
This review considers the rôle played by particular afferent pathways in the regulation of the activity of oxytocin and vasopressin cells.About:
This article is published in Progress in Neurobiology.The article was published on 1999-04-01. It has received 307 citations till now. The article focuses on the topics: Vasopressin & Oxytocin.read more
Citations
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Journal ArticleDOI
The Oxytocin Receptor System: Structure, Function, and Regulation
Gerald Gimpl,Falk Fahrenholz +1 more
TL;DR: The regulation by gonadal and adrenal steroids is one of the most remarkable features of the OT system and is, unfortunately, the least understood.
Journal ArticleDOI
Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable modes of neuropeptide communication
Rainer Landgraf,Inga D. Neumann +1 more
TL;DR: This concept considers neuropeptides in the extracellular fluid of the brain rather than those in the cerebrospinal fluid or plasma as primary signals, triggering a variety of receptor-mediated effects, including those underlying behavioral and neuroendocrine regulation and psychopathology.
Journal ArticleDOI
Dendritic peptide release and peptide-dependent behaviours
Mike Ludwig,Gareth Leng +1 more
TL;DR: The recently demonstrated ability of neuropeptides to prime vesicle stores for activity-dependent release could lead to a temporary functional reorganization of neuronal networks harbouring specific peptide receptors, providing a substrate for long-lasting effects.
Journal ArticleDOI
Physiology of Vasopressin Relevant to Management of Septic Shock
TL;DR: Clinical use of vasopressin should await a randomized controlled trial of its effects on clinical outcomes such as organ failure and mortality, because clinical studies have been relatively small, focused on physiologic end points, and because of potential adverse effects of vasipressin.
Journal ArticleDOI
The hypothalamic-neurohypophysial system regulates the hypothalamic-pituitary-adrenal axis under stress: an old concept revisited.
TL;DR: Data supporting the concept of HNS effects on HPA axis activity is presented and their possible impact on some aspects of behavioural regulation and psychopathology is outlined.
References
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Journal ArticleDOI
Voltage-gated calcium currents in the magnocellular neurosecretory cells of the rat supraoptic nucleus.
TL;DR: It is concluded that MNC soma express T‐, N‐, L‐, and P‐type calcium currents, as well as a novel low threshold nifedipine‐sensitive current and an unidentified inactivating component, suggesting a spatial and functional segregation of calcium current types in MNCs.
Journal ArticleDOI
Dorsomedial medulla stimulation activates rat supraoptic oxytocin and vasopressin neurones through different pathways.
W N Raby,L P Renaud +1 more
TL;DR: Observations indicate that visceral input mediated through the nucleus tractus solitarii is transmitted differentially to supraoptic vasopressin‐ and oxytocin‐secreting neurones in male Long‐Evans rats.
Journal ArticleDOI
Oxytocin predominantly excites putative oxytocin neurons in the rat supraoptic nucleus in vitro.
Hiroshi Yamashita,Shigeru Okuya,Kiyotoshi Inenaga,Masanori Kasai,Sayuri Uesugi,Hiroshi Kannan,Toshio Kaneko +6 more
TL;DR: The results suggest that OXT exerts predominantly excitatory effects in the SON and that putative OXT cells are more likely to be affected than putative vasopressin cells.
Journal ArticleDOI
c-fos may code for a common transcription factor within the hypothalamic neural circuits involved in osmoregulation.
TL;DR: C-fos protein (Fos) may be a common transcription factor in the hypothalamic neural circuits involved in osmoregulation in conscious rats and in hypertonic saline-injected rats.
Journal ArticleDOI
Effects of chemoreceptor and baroreceptor stimulation on the discharge of hypothalamic supraoptic neurones in rats.
TL;DR: The results show that anaesthesia of the carotid bifurcation abolished the effects of cardiovascular stimulation on the supraoptic neurones, and possible roles for the cardiovascular reflexes in control of vasopressin secretion are discussed.
Related Papers (5)
Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis.
David V. Pow,John F. Morris +1 more