Journal ArticleDOI
Placenta as a site for hematopoietic stem cell development
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TLDR
It is suggested that the placenta provides a supportive niche where the definitive hematopoietic stem cell pool can be temporarily established during development, and the stem cell-promoting properties of the placental niche can be harnessed in vitro to support HSC formation, maturation, and/or expansion in culture.About:
This article is published in Experimental Hematology.The article was published on 2005-09-01. It has received 135 citations till now. The article focuses on the topics: Hematopoietic stem cell & Placenta.read more
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Concise review: isolation and characterization of cells from human term placenta: outcome of the first international Workshop on Placenta Derived Stem Cells.
Ornella Parolini,Francesco Alviano,Gian Paolo Bagnara,Grozdana Bilic,Hans-Jörg Bühring,Marco Evangelista,Simone Hennerbichler,Bing Liu,Marta Magatti,Ning Mao,Toshio Miki,Fabio Marongiu,Hideaki Nakajima,Toshio Nikaido,C. Bettina Portmann-Lanz,Venkatachalam Sankar,Maddalena Soncini,Guido Stadler,Daniel Surbek,Tsuneo A. Takahashi,Heinz Redl,Norio Sakuragawa,Susanne Wolbank,Steffen M. Zeisberger,Andreas H. Zisch,Stephen C. Strom +25 more
TL;DR: The aim of this review is to summarize and provide the state of the art of research in this field, addressing aspects such as cell isolation protocols and characteristics of these cells, as well as providing preliminary indications of the possibilities for use ofThese cells in future clinical applications.
Journal ArticleDOI
Ontogeny of Tissue-Resident Macrophages.
TL;DR: Evidence now shows that certain macrophage populations are in fact independent from monocyte and even from adult bone marrow hematopoiesis, and derive from sequential seeding of tissues by two precursors during embryonic development.
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Fetal monocytes and the origins of tissue-resident macrophages.
TL;DR: Recent insights about the different embryonic hematopoietic programs responsible for the generation of long-lived tissue-resident macrophages and their maintenance after birth are proposed.
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The Transcriptional Landscape of Hematopoietic Stem Cell Ontogeny
Shannon McKinney-Freeman,Patrick Cahan,Hu Li,Hu Li,Scott A. Lacadie,Hsuan Ting Huang,Matthew Curran,Sabine Loewer,Olaia Naveiras,Katie L. Kathrein,Martina Konantz,Martina Konantz,Erin M. Langdon,Claudia Lengerke,Leonard I. Zon,James J. Collins,James J. Collins,James J. Collins,George Q. Daley +18 more
TL;DR: The transcriptomes of developing HSCs purified from >2,500 murine embryos and adult mice were acquired and it was found that embryonic hematopoietic elements clustered into three distinct transcriptional states characteristic of the definitive yolk sac, H SCs undergoing specification, and definitive HSCS.
Journal ArticleDOI
Fetal B-cell lymphopoiesis and the emergence of B-1-cell potential.
TL;DR: The possibility that distinct fetal and adult B-cell developmental programmes might be operative in humans is discussed and the emergence of B-1-cell potential during embryogenesis is focused on.
References
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Journal ArticleDOI
A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells
TL;DR: Counts of macroscopic splenic colonies were used to obtain an estimate of the radiation sensitivity of normal mouse bone marrow progenitor cells.
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Osteoblastic cells regulate the haematopoietic stem cell niche
Laura M. Calvi,Gregor B. Adams,Kathryn W. Weibrecht,Jonathan M. Weber,David P. Olson,M. C. Knight,Roderick P. Martin,Ernestina Schipani,P. Divieti,F. R. Bringhurst,Laurie A. Milner,Henry M. Kronenberg,David T. Scadden +12 more
TL;DR: Osteoblastic cells are a regulatory component of the haematopoietic stem cell niche in vivo that influences stem cell function through Notch activation.
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Identification of the haematopoietic stem cell niche and control of the niche size
Jiwang Zhang,Chao Niu,Ling Ye,Haiyang Huang,Xi C. He,Wei Gang Tong,Jason Ross,Jeffrey S. Haug,Teri Johnson,Jian Q. Feng,Stephen E. Harris,Leanne M. Wiedemann,Leanne M. Wiedemann,Yuji Mishina,Linheng Li,Linheng Li +15 more
TL;DR: It is concluded that SNO cells lining the bone surface function as a key component of the niche to support HSCs, and that BMP signalling through BMPRIA controls the number of H SCs by regulating niche size.
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Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell
TL;DR: A monoclonal antibody raised to the mouse homolog of CD34 (mCD34) was used to purify mouse HSCs to near homogeneity to enable analysis of the self-renewal and multilineage differentiation of individual HSCS.
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Definitive Hematopoiesis Is Autonomously Initiated by the AGM Region
TL;DR: A novel in vitro organ culture system is presented demonstrating that, at day 10 in gestation, hematopoietic stem cells initiate autonomously and exclusively within the aorta-gonad-mesonephros (AGM) region, suggesting that the AGM region is the source of the definitive adult hematosynthesis system, which subsequently colonizes the liver.