Plant associated fungal endophytes as a source of natural bioactive compounds
Nilesh Rai,Priyanka Kumari Keshri,Ashish Verma,Swapnil C. Kamble,Pradeep Mishra,Suvakanta Barik,Santosh Kumar Singh,Vibhav Gautam +7 more
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TLDR
The relationship of host plant and endophyte is significantly associated with alteration in fungal colonia and the results suggest that colonization by fungal spores alters the phytochemical properties of the host plant.Abstract:
Endophytes are a potent source of bioactive compounds that mimic plant-based metabolites. The relationship of host plant and endophyte is significantly associated with alteration in fungal colonisation and the extraction of endophyte-derived bioactive compounds. Screening of fungal endophytes and their relationship with host plants is essential for the isolation of bioactive compounds. Numerous bioactive compounds with antioxidant, antimicrobial, anticancer, and immunomodulatory properties are known to be derived from fungal endophytes. Bioinformatics tools along with the latest techniques such as metabolomics, next-generation sequencing, and metagenomics multilocus sequence typing can potentially fill the gaps in fungal endophyte research. The current review article focuses on bioactive compounds derived from plant-associated fungal endophytes and their pharmacological importance. We conclude with the challenges and opportunities in the research area of fungal endophytes.read more
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Fungal Endophytes: A Promising Frontier for Discovery of Novel Bioactive Compounds.
TL;DR: In this article, a review focusing on endophytic fungi and their classification, rationale for selection and prioritization of host plants for fungal isolation and examples of strategies that have been adopted to induce the activation of cryptic biosynthetic gene clusters to enhance the bioactive potential of fungal endophytes.
Journal ArticleDOI
Biological potential of bioactive metabolites derived from fungal endophytes associated with medicinal plants
Priyanka Kumari Keshri,Nilesh Rai,Ashish Verma,Swapnil C. Kamble,Suvakanta Barik,Pradeep Mishra,Santosh Kumar Singh,Prafull Salvi,Vibhav Gautam +8 more
TL;DR: The pharmaceutical importance of novel bioactive metabolites and their efficient production from fungal endophytes using various approaches like genetic engineering, use of elicitors, and precursor feeding are discussed.
Journal ArticleDOI
Metabolomic Insights Into Endophyte-Derived Bioactive Compounds
TL;DR: There is sufficient evidence for endophyte-derived plant metabolites, which could be pursued as alternative sources of commercially important plant metabolites as well as the contribution of plant and microbial metabolomics for answering fundamental questions of plant-endophyte interaction.
Journal ArticleDOI
Assessment of Biological Activities of Fungal Endophytes Derived Bioactive Compounds Isolated from Amoora rohituka
A. N. Verma,Priyamvada Gupta,Nilesh K. Rai,Rajan Kumar Tiwari,Ajay Kumar,Prafull Salvi,Swapnil C. Kamble,Santosh Kumar Singh,Vibhav Gautam +8 more
TL;DR: The present study signifies that fungal endophyte P. oxalicum associated with the leaf of A. rohituka could be a potential source of bioactive compounds with antioxidant and anticancer activity.
Journal ArticleDOI
Bioprospecting of fungal endophytes from Oroxylum indicum (L.) Kurz with antioxidant and cytotoxic activity
Nilesh K. Rai,Priyanka Kumari Keshri,Priyamvada Gupta,A. N. Verma,Swapnil C. Kamble,Santosh Kumar Singh,Vibhav Gautam +6 more
TL;DR: High-performance thin-layer chromatography of ethyl acetate extract of isolated fungal endophytes showed a distinct fingerprinting profile in EA extract of Colletotrichum gloeosporioides, and a comparative HPTLC fingerprinting and the antioxidant activity of C. gloeoosporios produces bioactive compounds in a host-dependent manner showed that C.gloeos porioides produces bio active compounds inA host- dependent manner.
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Journal ArticleDOI
Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia.
Journal ArticleDOI
In situ immune response and mechanisms of cell damage in central nervous system of fatal cases microcephaly by Zika virus
Raimunda do Socorro da Silva Azevedo,Jorge Rodrigues de Sousa,Marialva Tereza Ferreira de Araújo,Arnaldo Jorge Martins Filho,Bianca Nascimento de Alcantara,Fernanda Montenegro de Carvalho Araújo,Maria G. L. Queiroz,Ana Cecília Ribeiro Cruz,Beatriz H. Baldez Vasconcelos,Jannifer Oliveira Chiang,Lívia Carício Martins,Livia Medeiros Neves Casseb,Eliana Vieira Pinto da Silva,Valéria Lima Carvalho,Barbara Cristina Baldez Vasconcelos,Sueli Rodrigues,Consuelo Silva de Oliveira,Juarez Antônio Simões Quaresma,Pedro Fernando da Costa Vasconcelos +18 more
TL;DR: The in situ immune response profile and mechanisms of neuronal cell damage in fatal Zika microcephaly cases were investigated and changes found were mainly calcification, necrosis, neuronophagy, gliosis, microglial nodules, and inflammatory infiltration of mononuclear cells.