Prediction of dementia by subjective memory impairment: effects of severity and temporal association with cognitive impairment.
Frank Jessen,Birgitt Wiese,Cadja Bachmann,Sandra Eifflaender-Gorfer,Franziska Haller,Heike Kölsch,Tobias Luck,Edelgard Mösch,Hendrik van den Bussche,Michael Wagner,Anja Wollny,Thomas Zimmermann,Michael Pentzek,Steffi G. Riedel-Heller,Heinz-Peter Romberg,Siegfried Weyerer,Hanna Kaduszkiewicz,Wolfgang Maier,Horst Bickel +18 more
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The prediction of dementia in AD by SMI with subsequent amnestic MCI supports the model of a consecutive 3-stage clinical manifestation of AD from SMI via MCI to dementia.Abstract:
Context Subjective memory impairment (SMI) is receiving increasing attention as a pre-mild cognitive impairment (MCI) condition in the course of the clinical manifestation of Alzheimer disease (AD). Objectives To determine the risk for conversion to any dementia, dementia in AD, or vascular dementia by SMI, graded by the level of SMI-related worry and by the temporal association of SMI and subsequent MCI. Design Longitudinal cohort study with follow-up examinations at 1½ and 3 years after baseline. Setting Primary care medical record registry sample. Participants A total of 2415 subjects without cognitive impairment 75 years or older in the German Study on Aging, Cognition and Dementia in Primary Care Patients. Main Outcome Measures Conversion to any dementia, dementia in AD, or vascular dementia at follow-up 1 or follow-up 2 predicted by SMI with or without worry at baseline and at follow-up 2 predicted by different courses of SMI at baseline and MCI at follow-up 1. Results In the first analysis, SMI with worry at baseline was associated with greatest risk for conversion to any dementia (hazard ratio [HR], 3.53; 95% confidence interval [CI], 2.07-6.03) or dementia in AD (6.54; 2.82-15.20) at follow-up 1 or follow-up 2. The sensitivity was 69.0% and the specificity was 74.3% conversion to dementia in AD. In the second analysis, SMI at baseline and MCI at follow-up 1 were associated with greatest risk for conversion to any dementia (odds ratio [OR], 8.92; 95% CI, 3.69-21.60) or dementia in AD (19.33; 5.29-70.81) at follow-up 2. Furthermore, SMI at baseline and amnestic MCI at follow-up 1 increased the risk for conversion to any dementia (OR, 29.24; 95% CI, 8.75-97.78) or dementia in AD (60.28; 12.23-297.10), with a sensitivity of 66.7% and a specificity of 98.3% for conversion to dementia in AD. Conclusion The prediction of dementia in AD by SMI with subsequent amnestic MCI supports the model of a consecutive 3-stage clinical manifestation of AD from SMI via MCI to dementia.read more
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2016 Alzheimer's disease facts and figures
Journal ArticleDOI
A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease
Frank Jessen,Frank Jessen,Rebecca E. Amariglio,Martin P.J. van Boxtel,Monique M.B. Breteler,Mathieu Ceccaldi,Gaël Chételat,Bruno Dubois,Carole Dufouil,Kathryn A. Ellis,Wiesje M. van der Flier,Lidia Glodzik,Argonde C. van Harten,Mony J. de Leon,Pauline McHugh,Michelle M. Mielke,José Luis Molinuevo,Lisa Mosconi,Ricardo S. Osorio,Audrey Perrotin,Ronald C. Petersen,Laura A. Rabin,Lorena Rami,Barry Reisberg,Dorene M. Rentz,Perminder S. Sachdev,Vincent de La Sayette,Andrew J. Saykin,Philip Scheltens,Melanie B. Shulman,Melissa J. Slavin,Reisa A. Sperling,Robert Stewart,Olga Uspenskaya,Bruno Vellas,Pieter Jelle Visser,Pieter Jelle Visser,Michael Wagner,Michael Wagner +38 more
TL;DR: Research criteria for SCD in pre‐mild cognitive impairment (MCI) are presented and a list of core features proposed for reporting in SCD studies is provided, which will enable comparability of research across different settings.
Journal ArticleDOI
Defeating Alzheimer's disease and other dementias: a priority for European science and society
Bengt Winblad,Bengt Winblad,Philippe Amouyel,Sandrine Andrieu,Clive Ballard,Carol Brayne,Henry Brodaty,Angel Cedazo-Minguez,Bruno Dubois,David Edvardsson,David Edvardsson,Howard Feldman,Laura Fratiglioni,Giovanni B. Frisoni,Serge Gauthier,Jean Georges,Caroline Graff,Caroline Graff,Khalid Iqbal,Frank Jessen,Frank Jessen,Gunilla Johansson,Linus Jönsson,Miia Kivipelto,Miia Kivipelto,Martin Knapp,Francesca Mangialasche,René J. F. Melis,Agneta Nordberg,Agneta Nordberg,Marcel G. M. Olde Rikkert,Chengxuan Qiu,Thomas P. Sakmar,Thomas P. Sakmar,Philip Scheltens,Lon S. Schneider,Reisa A. Sperling,Lars O. Tjernberg,Gunhild Waldemar,Anders Wimo,Henrik Zetterberg,Henrik Zetterberg +41 more
TL;DR: This poster aims to demonstrate the efforts towards in-situ applicability of EMMARM, which aims to provide real-time information about the physical and cognitive properties of Alzheimer's disease and other dementias.
A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease
Frank Jessen,Frank Jessen,Rebecca E. Amariglio,Martin P.J. van Boxtel,Monique M.B. Breteler,Mathieu Ceccaldi,Gaël Chételat,Bruno Dubois,Carole Dufouil,Kathryn A. Ellis,Wiesje M. van der Flier,Lidia Glodzik,Argonde C. van Harten,Mony J. de Leon,Pauline McHugh,Michelle M. Mielke,José Luis Molinuevo,Lisa Mosconi,Ricardo S. Osorio,Audrey Perrotin,Ronald C. Petersen,Laura A. Rabin,Lorena Rami,Barry Reisberg,Dorene M. Rentz,Perminder S. Sachdev,Vincent de La Sayette,Andrew J. Saykin,Philip Scheltens,Melanie B. Shulman,Melissa J. Slavin,Reisa A. Sperling,Robert Stewart,Olga Uspenskaya,Bruno Vellas,Pieter Jelle Visser,Pieter Jelle Visser,Michael Wagner,Michael Wagner +38 more
TL;DR: In this paper, research criteria for subjective cognitive decline in individuals with unimpaired performance on cognitive tests may represent the first symptomatic manifestation of Alzheimer's disease (AD) are presented.
Journal ArticleDOI
Risk of dementia and mild cognitive impairment in older people with subjective memory complaints: meta-analysis
TL;DR: To investigate whether people with subjective memory complaints but no objective deficits are at increased risk of developing mild cognitive impairment (MCI) and dementia, and if so, how likely they are to develop dementia.
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