Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia
Mitsuro Kanda,Hanno Matthaei,Jian Wu,Seung-Mo Hong,Jun Yu,Michael Borges,Ralph H. Hruban,Anirban Maitra,Kenneth W. Kinzler,Bert Vogelstein,Michael Goggins +10 more
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TLDR
It is shown that more than 99% of the earliest-stage, lowest-grade, pancreatic intraepithelial neoplasm-1 lesions contain mutations in KRAS, p16/CDKN2A, GNAS, or BRAF, which could improve the understanding of the development and progression of these premalignant lesions.About:
This article is published in Gastroenterology.The article was published on 2012-04-01 and is currently open access. It has received 602 citations till now. The article focuses on the topics: Pancreatic Intraepithelial Neoplasia & Pancreatic cancer.read more
Citations
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Only women with symptoms need to have their breast implants removed, says government
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A Revised Classification System and Recommendations From the Baltimore Consensus Meeting for Neoplastic Precursor Lesions in the Pancreas.
Olca Basturk,Seung-Mo Hong,Laura D. Wood,N. Volkan Adsay,Jorge Albores-Saavedra,Andrew V. Biankin,Lodewijk A.A. Brosens,Noriyoshi Fukushima,Michael Goggins,Ralph H. Hruban,Yo Kato,David S. Klimstra,Günter Klöppel,Alyssa M. Krasinskas,Daniel S. Longnecker,Hanno Matthaei,G. Johan A. Offerhaus,Michio Shimizu,Kyoichi Takaori,Benoit Terris,Shinichi Yachida,Irene Esposito,Toru Furukawa +22 more
TL;DR: International experts met to discuss recent advances and to revise the 2004 recommendations for assessing and reporting precursor lesions to invasive carcinomas of the pancreas, including pancreatic intraepithelial neoplasia (PanIN), intraductal papillary mucinous neoplasms (IPMN), mucinous cystic neoplasm, and other lesions.
Journal ArticleDOI
Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma
Janel L. Kopp,Guido von Figura,Erin Mayes,Fenfen Liu,Claire L. Dubois,John P. Morris,Fong Cheng Pan,Haruhiko Akiyama,Christopher V.E. Wright,Kristin C. Jensen,Matthias Hebrok,Maike Sander +11 more
TL;DR: It is suggested that ductal and stem-like centroacinar cells are surprisingly refractory to oncogenic transformation, whereas acinar cells readily form PDA precursor lesions with ductal features, and formation of acinar-derived premalignant lesions depends on ectopic induction of the ductal gene Sox9.
Journal ArticleDOI
KRAS: feeding pancreatic cancer proliferation
TL;DR: A number of studies have shown that oncogenic KRAS plays a central role in controlling tumor metabolism by orchestrating multiple metabolic changes including stimulation of glucose uptake, differential channeling of glucose intermediates, reprogrammed glutamine metabolism, increased autophagy, and macropinocytosis.
Journal ArticleDOI
Oncogenic KRAS signalling in pancreatic cancer
TL;DR: Recent advances in oncogenic KRAS signalling are reviewed and how these might benefit PDAC treatment in the future are discussed.
References
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Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
Siân Jones,Xiaosong Zhang,D. Williams Parsons,D. Williams Parsons,Jimmy Lin,Rebecca J. Leary,Philipp Angenendt,Parminder Mankoo,Hannah Carter,Hirohiko Kamiyama,Antonio Jimeno,Seung-Mo Hong,Baojin Fu,Ming Tseh Lin,Eric S. Calhoun,Mihoko Kamiyama,Kimberly Walter,Tatiana Nikolskaya,Yuri Nikolsky,James Hartigan,Douglas Smith,Manuel Hidalgo,Steven D. Leach,Alison P. Klein,Elizabeth M. Jaffee,Michael Goggins,Anirban Maitra,Anirban Maitra,Christine A. Iacobuzio-Donahue,James R. Eshleman,Scott E. Kern,Ralph H. Hruban,Rachel Karchin,Nickolas Papadopoulos,Giovanni Parmigiani,Bert Vogelstein,Victor E. Velculescu,Kenneth W. Kinzler +37 more
TL;DR: It is found that pancreatic cancers contain an average of 63 genetic alterations, the majority of which are point mutations, which defined a core set of 12 cellular signaling pathways and processes that were each genetically altered in 67 to 100% of the tumors.
Journal ArticleDOI
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
Sunil R. Hingorani,Emanuel F. Petricoin,Anirban Maitra,Vinodh N. Rajapakse,Catrina King,Michael A. Jacobetz,Sally Ross,Thomas P. Conrads,Timothy D. Veenstra,Ben A. Hitt,Yoshiya Kawaguchi,Donald J. Johann,Lance A. Liotta,Howard C. Crawford,Mary E. Putt,Tyler Jacks,Christopher V.E. Wright,Ralph H. Hruban,Andrew M. Lowy,David A. Tuveson +19 more
TL;DR: It is found that physiological levels of Kras(G12D) induce ductal lesions that recapitulate the full spectrum of human pancreatic intraepithelial neoplasias (PanINs), putative precursors to invasive pancreatic cancer.
PatentDOI
Circulating Mutant DNA to Assess Tumor Dynamics
TL;DR: In this article, a highly sensitive approach to quantify circulating tumor DNA (ctDNA) in body samples of patients was applied to reliably monitor tumor dynamics in subjects with cancer, especially those who are undergoing surgery or chemotherapy.
Journal ArticleDOI
Pancreatic Intraepithelial Neoplasia: A New Nomenclature and Classification System for Pancreatic Duct Lesions
Ralph H. Hruban,N V Adsay,J Albores-Saavedra,Carolyn C. Compton,E S Garrett,Steven N. Goodman,Scott E. Kern,David S. Klimstra,Günther Klöppel,Daniel S. Longnecker,Jutta Lüttges,G. J. A. Offerhaus +11 more
TL;DR: The acceptance of a standard classification system will facilitate the study of pancreatic duct lesions, and will lead ultimately to a better understanding of their biologic importance.
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