Reduction of acetylcholine in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice
Yuko Kondo-Takuma,Masayuki Mizuno,Yo Tsuda,Yuta Madokoro,Kengo Suzuki,Toyohiro Sato,Hiroshi Takase,Yuto Uchida,Kenichi Adachi,Hideki Hida,Cesario V. Borlongan,Noriyuki Matsukawa +11 more
TLDR
In this article, the authors confirmed direct reduction of Ach release in the hippocampus of freely moving HCNP-pp knockout mice under an arousal state by the microdialysis method, suggesting that Ach may be a cholinergic regulator in the septo-hippocampal network.Abstract:
The cholinergic efferent network from the medial septal nucleus to the hippocampus plays an important role in learning and memory processes. This cholinergic projection can generate theta oscillations in the hippocampus to encode novel information. Hippocampal cholinergic neurostimulating peptide (HCNP), which induces acetylcholine (Ach) synthesis in the medial septal nuclei of an explant culture system, was purified from the soluble fraction of postnatal rat hippocampus. HCNP is processed from the N-terminal region of a 186-amino acid, 21-kDa HCNP precursor protein, also known as Raf kinase inhibitory protein and phosphatidylethanolamine-binding protein 1. Here, we confirmed direct reduction of Ach release in the hippocampus of freely moving HCNP-pp knockout mice under an arousal state by the microdialysis method. The levels of vesicular acetylcholine transporter were also decreased in the hippocampus of these mice in comparison with those in control mice, suggesting there was decreased incorporation of Ach into the synaptic vesicle. These results potently indicate that HCNP may be a cholinergic regulator in the septo-hippocampal network.read more
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Reduction of glutamatergic activity through cholinergic dysfunction in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice
Kengo Suzuki,Yoshiaki Ohi,Toyohiro Sato,Yoshitaka Tsuda,Yuta Madokoro,Masayuki Mizuno,Kenichi Adachi,Yuto Uchida,Akira Haji,Kosei Ojika,Noriyuki Matsukawa +10 more
TL;DR: In this paper , the importance of hippocampal cholinergic neuro-stimulating peptide (HCNP) in inducing acetylcholine synthesis in the medial septal nucleus was investigated.
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Reduction of glutamatergic activity through cholinergic dysfunction in the hippocampus of hippocampal cholinergic neurostimulating peptide precursor protein knockout mice
TL;DR: In this paper , it was shown that HCNP-precursor protein (pp) knockout mice electrophysiologically presented with glutamatergic dysfunction in the hippocampus with age.
Journal ArticleDOI
Direct Enhancement Effect of Hippocampal Cholinergic Neurostimulating Peptide on Cholinergic Activity in the Hippocampus
Yuta Madokoro,Daisuke Kato,Yoshitaka Tsuda,Itsumi Arakawa,Kengo Suzuki,Toyohiro Sato,Masayuki Mizuno,Yuto Uchida,Kosei Ojika,Noriyuki Matsukawa +9 more
TL;DR: In this article , the authors investigated whether hippocampal cholinergic neurostimulating peptide (HCNP) has a rescue function in the cholineergic dysfunction of HCNP-pp conditional knockout (cKO).
References
More filters
Journal ArticleDOI
Diversity of glycine receptors in the mouse retina: Localization of the α3 subunit
TL;DR: The role of the alpha4 subunit in retinal circuitry remains unclear as discussed by the authors, however, it has been shown that approximately half of the amacrine cells release glycine at their synapses with bipolar, other amACrine, and ganglion cells.
Journal ArticleDOI
Atrophy of the cholinergic basal forebrain in dementia with Lewy bodies and Alzheimer's disease dementia.
Michel J. Grothe,Christina Schuster,Florian Bauer,Helmut Heinsen,Johannes Prudlo,Johannes Prudlo,Stefan J. Teipel,Stefan J. Teipel +7 more
TL;DR: Dementia with Lewy bodies may be characterized by a more selective degeneration of the cholinergic BF compared to AD, which may be related to the differential cognitive profiles in both conditions.
Journal ArticleDOI
Hippocampal cholinergic neurostimulating peptides (HCNP).
Kosei Ojika,Shigehisa Mitake,Naoki Tohdoh,Stanley H. Appel,Yasushi Otsuka,Eiichi Katada,Noriyuki Matsukawa +6 more
TL;DR: Several lines of evidence obtained from studies of humans and animal models suggest that certain types of memory and learning disorders are associated with abnormal accumulation and expression of HCNP analogue peptide and/or its precursor protein mRNA in the hippocampus.
Journal ArticleDOI
Cholinergic circuits in cognitive flexibility.
TL;DR: Strong evidence indicates that cholinergic interneurons from the dorsomedial striatum are essential for facilitating the establishment of a new selected strategy; an effect that seems to depend mainly on activation of muscarinic receptors.
Journal ArticleDOI
Cholinergic basal forebrain atrophy predicts amyloid burden in Alzheimer’s disease
Stefan J. Teipel,Helmut Heinsen,Edson Amaro,Lea T. Grinberg,Lea T. Grinberg,Bernd J. Krause,Michel J. Grothe +6 more
TL;DR: It is suggested that BFCS atrophy is more closely associated with cortical amyloid burden than hippocampus atrophy in predementia AD, and hippocampus volume more accurately identified the diagnostic categories of AD, late and early MCI, and CN.