Regulation of microRNA processing in development, differentiation and cancer.
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TLDR
Evidence of post‐transcriptional regulation of miRNA expression in cancer is found and examples of altered miRNA processing in cancer are found.Abstract:
microRNA (miRNA) is a class of small, noncoding, regulatory RNAs. The ∼ 21 nt mature miRNA is processed from larger precursor molecules following a coordinated series of events. In theory, miRNA processing may be regulated at any of these steps. A growing body of evidence has demonstrated various steps in the miRNA biogenesis process for which regulation occurs. RNA editing of miRNA precursors, SNPs or mutations in the miRNA precursors, regulation by RNA binding proteins, alterations in the levels of key processing proteins, as well as a number of unknown mechanisms contribute to the regulation of miRNA processing. This article reviews the available literature on the regulation of miRNA processing that occurs within normal cells, during development or in diseases such as cancer.read more
Citations
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Journal ArticleDOI
miRNA-mRNA integrated analysis reveals roles for miRNAs in primary breast tumors
Espen Enerly,Israel Steinfeld,Kristine Kleivi,Kristine Kleivi,Suvi-Katri Leivonen,Miriam Ragle Aure,Hege G. Russnes,Jo Anders Rønneberg,Jo Anders Rønneberg,Hilde Johnsen,Roy Navon,Einar Andreas Rødland,Rami Mäkelä,Bjørn Naume,Merja Perälä,Olli Kallioniemi,Olli Kallioniemi,Vessela N. Kristensen,Vessela N. Kristensen,Zohar Yakhini,Zohar Yakhini,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale +22 more
TL;DR: This study presents and analyzes data derived from expression profiling of 799 miRNAs in 101 primary human breast tumors, along with genome-wide mRNA profiles and extensive clinical information, to identify statistical significant differential expression of mi RNAs between molecular intrinsic subtypes, and between samples with different levels of proliferation.
Journal ArticleDOI
Circulating microRNAs (miRNA) in serum of patients with prostate cancer.
Robert Mahn,Lukas C. Heukamp,Sebastian Rogenhofer,Alexander von Ruecker,Stefan C. Müller,Jörg Ellinger +5 more
TL;DR: Tumor-associated miRNAs in serum allow noninvasive discrimination of PCA and BPH patients, and serum miRNA decreased after prostatectomy, thereby indicating tumor-associated release of miRNA.
Journal ArticleDOI
The regulation of miRNA-211 expression and its role in melanoma cell invasiveness.
Joseph Mazar,Katherine DeYoung,Divya Khaitan,Edward A. Meister,Alvin J.O. Almodovar,James S. Goydos,Animesh Ray,Ranjan J. Perera +7 more
TL;DR: Findings that miR-211 is a direct posttranscriptional regulator of KCNMA1 expression as well as the dependence of this miRNA's expression on MITF activity, establishes mi R-211 as an important regulatory agent in human melanoma.
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miR-331-3p Regulates ERBB-2 Expression and Androgen Receptor Signaling in Prostate Cancer
TL;DR: Transfection of multiple prostate cancer cell lines with miR-331-3p reduced ERBB-2 mRNA and protein expression and blocked downstream phosphatidylinositol 3-kinase/AKT signaling, suggesting that miR+3p has the capacity to regulate signaling pathways critical to the development and progression of prostate cancer cells.
Journal ArticleDOI
miR-148a is Associated with Obesity and Modulates Adipocyte Differentiation of Mesenchymal Stem Cells through Wnt Signaling
Chunmei Shi,Min Zhang,Meiling Tong,Lei Yang,Lingxia Pang,Ling Chen,Guangfeng Xu,Xia Chi,Qin Hong,Yuhui Ni,Chen-Bo Ji,Xirong Guo +11 more
TL;DR: The results suggest that miR-148a is a biomarker of obesity in human subjects and mouse model, which represents a CREB-modulated miRNA that acts to repress Wnt1, thereby promoting adipocyte differentiation.
References
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MicroRNAs: Genomics, Biogenesis, Mechanism, and Function
TL;DR: Although they escaped notice until relatively recently, miRNAs comprise one of the more abundant classes of gene regulatory molecules in multicellular organisms and likely influence the output of many protein-coding genes.
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Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
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Journal ArticleDOI
MicroRNA expression profiles classify human cancers
Jun Lu,Gad Getz,Eric A. Miska,Eric A. Miska,Ezequiel Alvarez-Saavedra,Justin Lamb,David Peck,Alejandro Sweet-Cordero,Alejandro Sweet-Cordero,Benjamin L. Ebert,Benjamin L. Ebert,Raymond H. Mak,Raymond H. Mak,Adolfo A. Ferrando,James R. Downing,Tyler Jacks,H. Robert Horvitz,H. Robert Horvitz,Todd R. Golub,Todd R. Golub,Todd R. Golub +20 more
TL;DR: A new, bead-based flow cytometric miRNA expression profiling method is used to present a systematic expression analysis of 217 mammalian miRNAs from 334 samples, including multiple human cancers, and finds the miRNA profiles are surprisingly informative, reflecting the developmental lineage and differentiation state of the tumours.
Journal ArticleDOI
MicroRNA signatures in human cancers
George A. Calin,Carlo M. Croce +1 more
TL;DR: MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment and has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein-coding genes involved in cancer.
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