Journal ArticleDOI
Rheumatoid arthritis: Recent advances on its etiology, role of cytokines and pharmacotherapy.
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TLDR
New agents need to be explored, whether from synthetic or natural source, to find the answers for unresolved etiology of autoimmune diseases and to provide a quality of life to the patients suffering from these diseases specifically RA.About:
This article is published in Biomedicine & Pharmacotherapy.The article was published on 2017-08-01. It has received 213 citations till now. The article focuses on the topics: Rheumatoid factor & Proinflammatory cytokine.read more
Citations
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Journal ArticleDOI
Pathogenic Role of Immune Cells in Rheumatoid Arthritis: Implications in Clinical Treatment and Biomarker Development.
Hooi Yeen Yap,Sabrina Zi Yi Tee,Magdelyn Mei Theing Wong,Sook Khuan Chow,Suat-Cheng Peh,Sin-Yeang Teow +5 more
TL;DR: The pathogenic role of various immune cells and immunological molecules in RA is discussed and the importance of understanding the immune cells in treating RA is highlighted and in exploring novel biomarkers are highlighted.
Journal ArticleDOI
The global prevalence of rheumatoid arthritis: a meta-analysis based on a systematic review
Khalid Almutairi,Johannes C. Nossent,David B. Preen,Helen Keen,Helen Keen,Charles A. Inderjeeth +5 more
TL;DR: The objective is to determine the global population prevalence of rheumatoid arthritis (RA) based on population-based studies and assess factors that influence RA prevalence estimates, including geographical location, the risk bias assessment of studies and sample size.
Journal ArticleDOI
Recent progress regarding kaempferol for the treatment of various diseases (Review)
TL;DR: Kaempferol has beneficial effects against cancer, liver injury, obesity and diabetes, inhibits vascular endothelial inflammation, protects the cranial nerve and heart function, and may be used for treating fibroproliferative disorders, including hypertrophic scar.
Journal ArticleDOI
LncRNA PICSAR promotes cell proliferation, migration and invasion of fibroblast-like synoviocytes by sponging miRNA-4701-5p in rheumatoid arthritis.
Xuan Bi,X. Guo,Bi Yao Mo,Man Li Wang,Xi Qing Luo,Yi Xiong Chen,Fang Liu,Nancy J. Olsen,Yunfeng Pan,Song Guo Zheng +9 more
TL;DR: Results reveal PICSAR may exert an essential role in promoting synovial invasion and joint destruction by sponging miR-4701-5p in RA and that lncRNA PICS AR may act as a biomarker of RA.
Journal ArticleDOI
Two decades of research in discovery of anticancer drugs targeting STAT3, how close are we?
TL;DR: Signal transducer and activator of transcription 3 (STAT3) controls many biological processes including differentiation, survival, proliferation, and angiogenesis as discussed by the authors, however, despite decades of research, a FDA-approved STAT3 inhibitor has yet to emerge.
References
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Journal ArticleDOI
2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative.
Daniel Aletaha,Tuhina Neogi,Alan J. Silman,Julia Funovits,David T. Felson,Clifton O. Bingham,Neal S. Birnbaum,Gerd Burmester,Vivian P. Bykerk,Marc D. Cohen,Bernard Combe,Karen H. Costenbader,Maxime Dougados,Paul Emery,Gianfranco Ferraccioli,Johanna M. W. Hazes,Kathryn Hobbs,Tom W J Huizinga,Arthur Kavanaugh,Jonathan Kay,Tore K Kvien,Timothy J. Laing,Philip J. Mease,Henri A Ménard,Larry W. Moreland,Raymond L. Naden,Theodore Pincus,Josef S Smolen,Ewa Stanislawska-Biernat,Deborah P M Symmons,Paul P. Tak,Katherine S. Upchurch,Jiří Vencovský,Frederick Wolfe,Gillian A. Hawker +34 more
TL;DR: This new classification system redefines the current paradigm of RA by focusing on features at earlier stages of disease that are associated with persistent and/or erosive disease, rather than defining the disease by its late-stage features.
Journal ArticleDOI
Toll-like receptors.
TL;DR: This unit discusses mammalian Toll receptors (TLR1‐10) that have an essential role in the innate immune recognition of microorganisms and are discussed are TLR‐mediated signaling pathways and antibodies that are available to detect specific TLRs.
Journal ArticleDOI
The pathogenesis of rheumatoid arthritis.
Iain B. McInnes,Georg Schett +1 more
TL;DR: The increased understanding of the immune mechanisms of rheumatoid arthritis has led to the development of a considerable number of new therapeutic agents that alter the natural history of the disease and reduce mortality.
Journal ArticleDOI
Evolving concepts of rheumatoid arthritis
TL;DR: Based on the pathogenic mechanisms, specific therapeutic interventions can be designed to suppress synovial inflammation and joint destruction in rheumatoid arthritis.
Journal ArticleDOI
OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis
Young-Yun Kong,Hiroki Yoshida,Ildiko Sarosi,Hong-Lin Tan,Emma Timms,Casey Capparelli,Sean Morony,Antonio J. Oliveira-dos-Santos,Gwyneth Van,Annick Itie,Wilson Khoo,Andrew Wakeham,Colin R. Dunstan,David L. Lacey,Tak W. Mak,William J. Boyle,Josef M. Penninger +16 more
TL;DR: OPGL is a new regulator of lymph-node organogenesis and lymphocyte development and is an essential osteoclast differentiation factor in vivo.
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2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative.
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