Journal ArticleDOI
Roles of Sca-1 in hematopoietic stem/progenitor cell function.
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TLDR
Data indicate that Sca-1 plays a role in hematopoietic progenitor/stem cell lineage fate and c-kit expression, and affects human as well as mouse stem/progenitor cell activity, suggesting the possibility of a functional human ScA-1 homologue.About:
This article is published in Experimental Hematology.The article was published on 2005-07-01. It has received 131 citations till now. The article focuses on the topics: Progenitor cell & Endothelial stem cell.read more
Citations
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Combined Single-Cell Functional and Gene Expression Analysis Resolves Heterogeneity within Stem Cell Populations
Nicola K. Wilson,David G. Kent,Florian Buettner,Mona Shehata,Iain C. Macaulay,Fernando J Calero-Nieto,Manuel Sánchez Castillo,Caroline A. Oedekoven,Evangelia Diamanti,Reiner Schulte,Chris P. Ponting,Chris P. Ponting,Thierry Voet,Thierry Voet,Carlos Caldas,John Stingl,Anthony R. Green,Fabian J. Theis,Berthold Göttgens +18 more
TL;DR: An unbiased sorting strategy is designed that separates non-HSCs away from HSCs, and single-cell transplantation experiments using the enriched population were combined with RNA-seq data to identify key molecules that associate with long-term durable self-renewal, producing a single- cell molecular dataset that is linked to functional stem cell activity.
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Concise review: stem cell antigen-1: expression, function, and enigma.
TL;DR: A review of the plethora of recent findings utilizing Sca‐1 as a parenchymal stem cell marker and detailing its functional role in stem and progenitor cells and also attempts to explain the lingering mysteries surrounding its biochemical function and human ortholog.
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Cytotoxic CD8+ T Cells Stimulate Hematopoietic Progenitors by Promoting Cytokine Release from Bone Marrow Mesenchymal Stromal Cells
TL;DR: This study indicates that, during an acute viral infection, CTLs indirectly modulate early multipotent hematopoietic progenitors via MSCs in order to trigger the temporary activation of emergency myelopoiesis and promote clearance of the infection.
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Chromatin regulatory mechanisms in pluripotency.
TL;DR: These genetic studies help define the arena for future mechanistic studies that might be helpful to harness pluripotency for therapeutic goals.
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A distinct population of clonogenic and multipotent murine follicular keratinocytes residing in the upper isthmus.
Uffe Birk Jensen,Xiaohong Yan,Charlotte Triel,Seung-Hyun Woo,Rikke Christensen,David M. Owens +5 more
TL;DR: The authors identified a distinct population of murine hair follicle keratinocytes residing in the upper isthmus (UI) between the infundibulum and bulge regions that are distinguished by low α6 integrin levels and are negative for CD34 and Sca-1.
References
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Journal ArticleDOI
Purification and Characterization of Mouse Hematopoietic Stem Cells
TL;DR: Mouse bone marrow hematopoietic stem cells were isolated with the use of a variety of phenotypic markers and thirty of these cells are sufficient to save 50 percent of lethally irradiated mice, and to reconstitute all blood cell types in the survivors.
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A clonogenic common myeloid progenitor that gives rise to all myeloid lineages
TL;DR: The prospective identification, purification and characterization, using cell-surface markers and flow cytometry, of a complementary clonogenic common myeloid progenitor that gives rise to all myeloids lineages is reported.
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Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow
TL;DR: The Lin(-)IL-7R(+)Thy-1(-)Sca-1loc-Kit(lo) population from adult mouse bone marrow possessed a rapid lymphoid-restricted (T, B, and NK) reconstitution capacity in vivo but completely lacked myeloid differentiation potential either in vivo or in vitro.
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Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction
Hidemasa Oh,Steven B. Bradfute,Teresa D. Gallardo,Teruya Nakamura,Vinciane Gaussin,Yuji Mishina,Jennifer Pocius,Lloyd H. Michael,Richard R. Behringer,Daniel J. Garry,Mark L. Entman,Michael D. Schneider +11 more
TL;DR: The existence of adult heart-derived cardiac progenitor cells expressing stem cell antigen-1.5 is reported, and differentiation was shown to occur roughly equally, with and without fusion to host cells.
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uPAR: a versatile signalling orchestrator
Francesco Blasi,Peter Carmeliet +1 more
TL;DR: The urokinase receptor uPAR was originally thought to assist the directional invasion of migrating cells, but it is now becoming increasingly evident that this proteinase receptor elicits a plethora of cellular responses that include cellular adhesion, differentiation, proliferation and migration in a non-proteolytic fashion.