Journal ArticleDOI
Salidroside - Can it be a Multifunctional Drug?
Sri Krishna Jayadev Magani,Sri Durgambica Mupparthi,Bhanu Prakash Gollapalli,Dhananjay Shukla,A K Tiwari,Jyotsna Gorantala,Nagendra Sastry Yarla,Srinivasan Tantravahi +7 more
TLDR
This review aims to provide an overview of the metabolism of salidroside, its role in alleviating different metabolic disorders, diseases and its molecular interaction with the target molecules in different conditions to pave the way to clinically translate the use of saldroside as a multi-functional drug for various diseases and disorders in the near future.Abstract:
Background Salidroside is a glucoside of tyrosol found mostly in the roots of Rhodiola spp. It exhibits diverse biological and pharmacological properties. In the last decade, enormous research is conducted to explore the medicinal properties of salidroside; this research reported many activities like anti-cancer, anti-oxidant, anti-aging, anti-diabetic, anti-depressant, anti-hyperlipidemic, anti-inflammatory, immunomodulatory, etc. Objective: Despite its multiple pharmacological effects, a comprehensive review detailing its metabolism and therapeutic activities is still missing. This review aims to provide an overview of the metabolism of salidroside, its role in alleviating different metabolic disorders, diseases and its molecular interaction with the target molecules in different conditions. This review mostly concentrates on the metabolism, biological activities and molecular pathways related to various pharmacological activities of salidroside. Conclusion Salidroside is produced by a three-step pathway in the plants with tyrosol as an intermediate molecule. The molecule is biotransformed into many metabolites through phase I and II pathways. These metabolites, together with a certain amount of salidroside may be responsible for various pharmacological functions. The salidroside based inhibition of PI3k/AKT, JAK/ STAT, and MEK/ERK pathways and activation of apoptosis and autophagy are the major reasons for its anti-cancer activity. AMPK pathway modulation plays a significant role in its anti-diabetic activity. The neuroprotective activity was linked with decreased oxidative stress and increased antioxidant enzymes, Nrf2/HO-1 pathways, decreased inflammation through suppression of NF-κB pathway and PI3K/AKT pathways. These scientific findings will pave the way to clinically translate the use of salidroside as a multi-functional drug for various diseases and disorders in the near future.read more
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Journal ArticleDOI
Salidroside alleviates liver inflammation in furan-induced mice by regulating oxidative stress and endoplasmic reticulum stress
Yuan Yuan,Ziyue Wang,Bo Nan,Chaoyue Yang,Minghua Wang,Haiqing Ye,Chunyu Xi,Yan Zhang,Haiyang Yan +8 more
TL;DR: In this article, Salidroside (SAL) was shown to suppress the activity and the high expression of hepatic CYP2E1, and alleviated liver OS induced by furan.
Journal ArticleDOI
Secondary Metabolites as Treatment of Choice for Metabolic Disorders and Infectious Diseases and their Metabolic Profiling: Part 1.
Journal ArticleDOI
Research Progress on Natural Product Ingredients' Therapeutic Effects on Parkinson's Disease by Regulating Autophagy
TL;DR: In this article, the effects of natural products ingredients, such as salidroside, paeoniflorin, curcumin, resveratrol, corynoxine, and baicalein, on regulating autophagy and protecting neurons were discussed in detail to provide a reference for the research and development of drugs for the treatment of Parkinson's disease.
Journal ArticleDOI
Salidroside Prevents Hypoxia-Induced Human Retinal Microvascular Endothelial Cell Damage Via miR-138/ROBO4 Axis
TL;DR: In this article, Salidroside (SAL) is used to attenuate hypoxia-induced retinal microvascular endothelial cells (HRMECs) injury by culturing under hypoxic condition.
Journal ArticleDOI
Pharmacological effects of salidroside on central nervous system diseases.
Meihua Jin,Chun-Feng Wang,Yifeng Xu,Zijing Zhang,Xueyan Wu,Runfa Ye,Qinggao Zhang,Donghe Han +7 more
TL;DR: Salidroside (SAL) is a phenylpropanoid glycoside monomer extracted from Rhodiola at high altitudes as discussed by the authors , which has been proven to have protective effects on myocardial injury, liver cancer, renal fibrosis, and other organ diseases, as well as play neuroprotective roles in central nervous system (CNS) diseases.
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TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors (GBD) study provides such information but does not routinely aggregate results that are of interest to clinicians specialising in neurological conditions as discussed by the authors.