Journal ArticleDOI
Significance of intratumoral infiltration of B cells in cancer immunotherapy: From a single cell perspective.
TLDR
In this article, the authors discuss the tumor-infiltrated B cells' subpopulations, differentiation trajectory, and interactions with other cells in the tumor microenvironment (TME).About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2021-10-06. It has received 5 citations till now. The article focuses on the topics: Cancer immunotherapy & Immunoglobulin secretion.read more
Citations
More filters
Journal ArticleDOI
A CD8+ T cell-associated immune gene panel for prediction of the prognosis and immunotherapeutic effect of melanoma
TL;DR: Results unfolded that a low CDIGPM showed relevance to immune response-correlated pathways, high expressions of CTLA4 and PD-L1, a high infiltration rate of CD8+ T cells, and more benefits from immunotherapy.
Journal ArticleDOI
Tumor stemness score to estimate epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSCs) characterization and to predict the prognosis and immunotherapy response in bladder urothelial carcinoma
TL;DR: Wang et al. as discussed by the authors explored biomarkers of tumor stemness (TS) by single-cell sequencing analysis and identified subtypes of bladder urothelial carcinoma (BLCA) using clustering analysis based on TS biomarkers.
Journal ArticleDOI
Roles and mechanisms of tumour-infiltrating B cells in human cancer: a new force in immunotherapy
Enkui Zhang,Chengsheng Ding,Shichun Li,Xueliang Zhou,Batuer Aikemu,Xiaodong Fan,Jing Sun,Minhua Zheng,Xiao Yang +8 more
TL;DR: In this paper , the authors summarized recent advances regarding the role and underlying mechanisms of B cells in human cancer and therapy, and depicted the current landscape of b cells in cancers and paved the way for future research in this field.
Journal ArticleDOI
Nanomedicines: intervention in inflammatory pathways of cancer
Firoz Anwar,Salma Naqvi,Saiba Shams,Ryan A. Sheikh,Fahad A. Al-Abbasi,Amer H. Asseri,Vikas Kumar +6 more
TL;DR: In this article , a review on the inflammatory pathways in progression of a tumor, and advancement in nanotechnologies targeting these pathways is presented, and gaps that hinder the successful clinical translation of nanotherapeutics with further clinical studies that will allow oncologist to precisely identify the patients who may be benefited from nanotherapy at time when promotion or progression of tumor initiates.
Journal ArticleDOI
An immune-related gene prognostic risk index for pancreatic adenocarcinoma
Yang Su,Ruo-Mei Qi,Lan-Lan Li,Xu Wang,Sijin Li,Xiulan Zhao,Rui Hou,Wen Ma,Dan Liu,Junnian Zheng,Ming Shi +10 more
TL;DR: The composite results pointed out that low IRGPRI was associated with immune response-related pathways, high level of CTLA4, low KRAS and TP53 mutation rate, more infiltration of M2 macrophages, and more benefits from ICIs therapy.
References
More filters
Journal ArticleDOI
Massively parallel digital transcriptional profiling of single cells
Grace X.Y. Zheng,Jessica M. Terry,Phillip Belgrader,Paul Ryvkin,Zachary Bent,Ryan Wilson,Solongo B. Ziraldo,Tobias Daniel Wheeler,Geoffrey P. McDermott,Junjie Zhu,Mark T. Gregory,Joe Shuga,Luz Montesclaros,Jason G. Underwood,Donald A. Masquelier,Stefanie Y. Nishimura,Michael Schnall-Levin,Paul Wyatt,Christopher Hindson,Rajiv Bharadwaj,Alexander Wong,Kevin D. Ness,Lan Beppu,H. Joachim Deeg,Christopher McFarland,Keith R. Loeb,Keith R. Loeb,William J. Valente,William J. Valente,Nolan G. Ericson,Emily A. Stevens,Jerald P. Radich,Tarjei S. Mikkelsen,Benjamin J. Hindson,Jason H. Bielas +34 more
TL;DR: A droplet-based system that enables 3′ mRNA counting of tens of thousands of single cells per sample is described and sequence variation in the transcriptome data is used to determine host and donor chimerism at single-cell resolution from bone marrow mononuclear cells isolated from transplant patients.
Journal ArticleDOI
Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
Itay Tirosh,Benjamin Izar,Benjamin Izar,Sanjay M. Prakadan,Marc H. Wadsworth,Daniel J. Treacy,John J. Trombetta,Asaf Rotem,Asaf Rotem,Christopher Rodman,Christine G. Lian,George F. Murphy,Mohammad Fallahi-Sichani,Ken Dutton-Regester,Ken Dutton-Regester,Ken Dutton-Regester,Jia-Ren Lin,Ofir Cohen,Parin Shah,Diana Lu,Alex S. Genshaft,Travis K. Hughes,Carly G. K. Ziegler,Samuel W. Kazer,Aleth Gaillard,Kellie E. Kolb,Alexandra-Chloé Villani,Cory M. Johannessen,Aleksandr Andreev,Eliezer M. Van Allen,Eliezer M. Van Allen,Monica M. Bertagnolli,Monica M. Bertagnolli,Peter K. Sorger,Ryan J. Sullivan,Keith T. Flaherty,Dennie T. Frederick,Judit Jané-Valbuena,Charles H. Yoon,Charles H. Yoon,Orit Rozenblatt-Rosen,Alex K. Shalek,Aviv Regev,Aviv Regev,Aviv Regev,Levi A. Garraway +45 more
TL;DR: The cellular ecosystem of tumors is begin to unravel and how single-cell genomics offers insights with implications for both targeted and immune therapies is unraveled.
Journal ArticleDOI
B cells and tertiary lymphoid structures promote immunotherapy response
Beth A. Helmink,Sangeetha M. Reddy,Jianjun Gao,Shaojun Zhang,Rafet Basar,Rohit Thakur,Keren Yizhak,Moshe Sade-Feldman,Moshe Sade-Feldman,Jorge Blando,Guangchun Han,Vancheswaran Gopalakrishnan,Yuanxin Xi,Hao Zhao,Rodabe N. Amaria,Hussein Abdul-Hassan Tawbi,Alex P. Cogdill,Wenbin Liu,Valerie S. LeBleu,Fernanda G. Kugeratski,Sapna Pradyuman Patel,Michael A. Davies,Patrick Hwu,Jeffrey E. Lee,Jeffrey E. Gershenwald,Anthony Lucci,Reetakshi Arora,Scott E. Woodman,Emily Z. Keung,Pierre Olivier Gaudreau,Alexandre Reuben,Christine N. Spencer,Elizabeth M. Burton,Lauren E. Haydu,Alexander J. Lazar,Roberta Zapassodi,Courtney W. Hudgens,Deborah A. Ledesma,SuFey Ong,Michael Bailey,Sarah Warren,Disha Rao,Oscar Krijgsman,Elisa A. Rozeman,Daniel S. Peeper,Christian U. Blank,Ton N. Schumacher,Lisa H. Butterfield,Monika A. Zelazowska,Kevin M. McBride,Raghu Kalluri,James P. Allison,Florent Petitprez,Florent Petitprez,Wolf H. Fridman,Wolf H. Fridman,Catherine Sautès-Fridman,Catherine Sautès-Fridman,Nir Hacohen,Nir Hacohen,Katayoun Rezvani,Padmanee Sharma,Michael T. Tetzlaff,Linghua Wang,Jennifer A. Wargo +64 more
TL;DR: B cell markers were the most differentially expressed genes in the tumours of responders versus non-responders and insights are provided into the potential role of B cells and tertiary lymphoid structures in the response to ICB treatment, with implications for the development of biomarkers and therapeutic targets.
Journal ArticleDOI
Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment.
Elham Azizi,Ambrose J. Carr,Ambrose J. Carr,George Plitas,Andrew E. Cornish,Catherine Konopacki,Sandhya Prabhakaran,Juozas Nainys,Juozas Nainys,Kenmin Wu,Vaidotas Kiseliovas,Vaidotas Kiseliovas,Manu Setty,Kristy Choi,Rachel M. Fromme,Phuong Dao,Peter T. McKenney,Peter T. McKenney,Ruby C. Wasti,Krishna Kadaveru,Linas Mazutis,Alexander Y. Rudensky,Dana Pe'er +22 more
TL;DR: A preprocessing pipeline, SEQC, and a Bayesian clustering and normalization method, Biscuit, are developed to address computational challenges inherent to single-cell data and support a model of continuous activation in T cells and do not comport with the macrophage polarization model in cancer.
Journal ArticleDOI
Myeloid-Derived Suppressor Cells
TL;DR: Ample evidence supports a key role for MDSCs in immune suppression in cancer, as well as their prominent role in tumor angiogenesis, drug resistance, and promotion of tumor metastases.
Related Papers (5)
Tumor-immune profiling of murine syngeneic tumor models as a framework to guide mechanistic studies and predict therapy response in distinct tumor microenvironments.
Jun Yu,Sabyasachi Bhattacharya,Niranjan Yanamandra,David J. Kilian,Hong Shi,Sapna Yadavilli,Yuliya V. Katlinskaya,Heather Kaczynski,Michael Conner,William G. Benson,Ashleigh Hahn,Laura M. Seestaller-Wehr,Meixia Bi,Nicholas J. Vitali,Lyuben Tsvetkov,Wendy S. Halsey,Ashley M. Hughes,Christopher M. Traini,Hui Zhou,Junping Jing,Tae Lee,David J. Figueroa,Sara Brett,Christopher B. Hopson,James F. Smothers,Axel Hoos,Roopa Srinivasan +26 more
Tumor Cell-Intrinsic Factors Underlie Heterogeneity of Immune Cell Infiltration and Response to Immunotherapy
Jinyang Li,Katelyn T. Byrne,Fangxue Yan,Taiji Yamazoe,Zeyu Chen,Timour Baslan,Lee P. Richman,Jeffrey H. Lin,Yu H. Sun,Andrew J. Rech,David Balli,Ceire A. Hay,Yogev Sela,Allyson J. Merrell,Shannon M. Liudahl,Naomi Gordon,Robert J. Norgard,Salina Yuan,Sixiang Yu,Timothy Chao,Shuai Ye,T.S. Karin Eisinger-Mathason,Robert B. Faryabi,John W. Tobias,Scott W. Lowe,Scott W. Lowe,Lisa M. Coussens,E. John Wherry,Robert H. Vonderheide,Ben Z. Stanger +29 more