Journal ArticleDOI
Spontaneous Development of Synchronous Oscillatory Activity During Maturation of Cortical Networks In Vitro
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TLDR
It is shown that synchronous network activity depends on both glutamatergic and GABA(A)ergic neurotransmission during a brief period, and a period of synaptic depression after bursts is found that can explain the episodic nature of spontaneous network activity.Abstract:
Recent studies have focused attention on mechanisms of spontaneous large-scale wavelike activity during early development of the neocortex. In this study, we describe and characterize synchronous n...read more
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GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
TL;DR: It is suggested that an evolutionary preserved role for excitatory GABA in immature cells provides an important mechanism in the formation of synapses and activity in neuronal networks.
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An extremely rich repertoire of bursting patterns during the development of cortical cultures
TL;DR: Dissociated cultures of cortical cells exhibited a much richer repertoire of activity patterns than previously reported, except for the very sparsest cultures, which exhibited globally synchronized bursts, but bursting patterns changed over the course of development, and varied considerably between preparations.
Journal ArticleDOI
Controlling Bursting in Cortical Cultures with Closed-Loop Multi-Electrode Stimulation
TL;DR: It is concluded that externally applied electrical stimulation can substitute for natural inputs to cortical neuronal ensembles in transforming burst-dominated activity to dispersed spiking, more reminiscent of the awake cortex in vivo.
Journal ArticleDOI
Complex Oscillatory Waves Emerging from Cortical Organoids Model Early Human Brain Network Development.
Cleber A. Trujillo,Richard Gao,Priscilla D. Negraes,Jing Gu,Justin Buchanan,Sebastian Preissl,Allen Wang,Wei Wu,Gabriel G. Haddad,Isaac A. Chaim,Alain Domissy,Matthieu Vandenberghe,Anna Devor,Gene W. Yeo,Bradley Voytek,Alysson R. Muotri +15 more
TL;DR: Human cortical organoids that dynamically change cellular populations during maturation and exhibited consistent increases in electrical activity over the span of several months show that the development of structured network activity in a human neocortex model may follow stable genetic programming.
Journal ArticleDOI
Generation of functional hippocampal neurons from self-organizing human embryonic stem cell-derived dorsomedial telencephalic tissue
Hideya Sakaguchi,Taisuke Kadoshima,Mika Soen,Nobuhiro Narii,Yoshihito Ishida,Masatoshi Ohgushi,Jun Takahashi,Mototsugu Eiraku,Yoshiki Sasai +8 more
TL;DR: An in vitro model that recapitulates human hippocampus development is developed, allowing the generation of functional hippocampal granule- and pyramidal-like neurons.
References
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Journal ArticleDOI
Magnesium gates glutamate-activated channels in mouse central neurones
TL;DR: The voltage dependence of the NMDA receptor-linked conductance appears to be a consequence of the voltage dependenceof the Mg2+ block and its interpretation does not require the implication of an intramembrane voltage-dependent ‘gate’.
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NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones
Amy B. MacDermott,Amy B. MacDermott,Mark L. Mayer,Gary L. Westbrook,Stephen J. Smith,Jeffery L. Barker +5 more
TL;DR: It is directly demonstrated that excitatory amino acids acting at NMDA receptors on spinal cord neurones increase the intracellular Ca2+ activity, measured using the indicator dye arsenazo III, and that this is the result of Ca2- influx through NMDA receptor channels.
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Giant synaptic potentials in immature rat CA3 hippocampal neurones.
TL;DR: In neurones in which evoked GDPs were blocked by bicuculline, a NMDA‐mediated component was revealed by increasing the strength or the frequency of stimulation, and during the second week of postnatal life, superfusion with bicuciulline induced, as in adult slices, interictal discharges.
Journal ArticleDOI
Mice Deficient in Cellular Glutathione Peroxidase Show Increased Vulnerability to Malonate, 3-Nitropropionic Acid, and 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine
Péter Klivényi,Ole A. Andreassen,Robert J. Ferrante,Alpaslan Dedeoglu,Gerald Mueller,Eric Lancelot,Mikhail B. Bogdanov,Julie K. Andersen,Dongmei Jiang,M. Flint Beal,M. Flint Beal +10 more
TL;DR: The present results indicate that a knock-out of GSHPx may be adequately compensated under nonstressed conditions, but that after administration of mitochondrial toxins GSHpx plays an important role in detoxifying increases in oxygen radicals.
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GABA: an excitatory transmitter in early postnatal life
TL;DR: In the adult mammalian CNS, GABA is the main inhibitory transmitter, and during the early neonatal period, GABA acting on GABAA receptors provides most of the excite drive, whereas excitatory glutamatergic synapses are quiescent.