Journal ArticleDOI
The 2001 Bethesda System: terminology for reporting results of cervical cytology.
Diane Solomon,Diane D. Davey,Robert J. Kurman,Marianne U. Prey,Stephen S. Raab,Mark E. Sherman,David C. Wilbur,Nancy A. Young +7 more
TLDR
The 2001 Bethesda System terminology reflects important advances in biological understanding of cervical neoplasia and cervical screening technology.Abstract:
ObjectivesThe Bethesda 2001 Workshop was convened to evaluate and update the 1991
Bethesda System terminology for reporting the results of cervical cytology.
A primary objective was to develop a new approach to broaden participation
in the consensus process.ParticipantsForum groups composed of 6 to 10 individuals were responsible for developing
recommendations for discussion at the workshop. Each forum group included
at least 1 cytopathologist, cytotechnologist, clinician, and international
representative to ensure a broad range of views and interests. More than 400
cytopathologists, cytotechnologists, histopathologists, family practitioners,
gynecologists, public health physicians, epidemiologists, patient advocates,
and attorneys participated in the workshop, which was convened by the National
Cancer Institute and cosponsored by 44 professional societies. More than 20
countries were represented.EvidenceLiterature review, expert opinion, and input from an Internet bulletin
board were all considered in developing recommendations. The strength of evidence
of the scientific data was considered of paramount importance.Consensus ProcessBethesda 2001 was a year-long iterative review process. An Internet
bulletin board was used for discussion of issues and drafts of recommendations.
More than 1000 comments were posted to the bulletin board over the course
of 6 months. The Bethesda Workshop, held April 30-May 2, 2001, was open to
the public. Postworkshop recommendations were posted on the bulletin board
for a last round of critical review prior to finalizing the terminology.ConclusionsBethesda 2001 was developed with broad participation in the consensus
process. The 2001 Bethesda System terminology reflects important advances
in biological understanding of cervical neoplasia and cervical screening technology.read more
Citations
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Journal ArticleDOI
A comprehensive evaluation of the accuracy of cervical pre-cancer detection methods in a high-risk area in East Congo
S. Hovland,Marc Arbyn,A. K. Lie,Walter Ryd,B. Borge,E.J. Berle,Hanne Skomedal,T.M. Kadima,L. Kyembwa,E.M. Billay,D. Mukwege,R.B. Chirimwami,T.M. Mvula,Peter J.F. Snijders,Christophorus Joannes Lambertus Maria Meijer,Frank Karlsen +15 more
TL;DR: Both HPV detection assays showed a higher sensitivity for CIN2+ than did cytological methods and a similar specificity to cytology and a significantly higher specificity than consensus HR HPV DNA.
Journal ArticleDOI
HPV Testing by cobas HPV Test in a Population from Catalonia
Belen Lloveras,Sílvia Gómez,Francesc Alameda,Beatriz Bellosillo,Sergi Mojal,Mercè Muset,Manuel Parra,Jose C. Palomares,Sergi Serrano +8 more
TL;DR: The cobas HPV Test results fulfilled sensitivity and specificity requirements for HPV based cervical cancer screening and for the triage of minor cytological abnormalities, allowing its introduction in clinical settings.
Journal ArticleDOI
Risk detection for high-grade cervical disease using Onclarity HPV extended genotyping in women, ≥21 years of age, with ASC-US or LSIL cytology.
Thomas C. Wright,Mark H. Stoler,Valentin Parvu,Karen Yanson,Charles K. Cooper,Jeffrey C Andrews +5 more
TL;DR: The results support a 1-year follow-up period to preclude immediate colposcopy for ASC-US or LSIL women positive for the lowest-risk HPV genotypes.
Journal ArticleDOI
Evaluation of an ELISA for p16INK4a as a screening test for cervical cancer.
Akhila Balasubramanian,James P. Hughes,Constance Mao,Ruediger Ridder,Matthias Herkert,Nancy B. Kiviat,Laura A. Koutsky +6 more
TL;DR: An enhanced version of this prototypic p16INK4a ELISA showed promise in screening, particularly when combined with hc2, and was referred for histologic diagnosis.
Journal ArticleDOI
Comparison of urine and cervical samples for detecting human papillomavirus (HPV) with the Cobas 4800 HPV test.
Samuel Bernal,Jose C. Palomares,Antonio Artura,Manuel Parra,Jose Luis Cabezas,Antonio Robles,Estrella Martin Mazuelos +6 more
TL;DR: Compared to histologically confirmed CIN 2/3 disease, the clinical sensitivity and specificity for the detection of high-risk HPV in urine samples were 95% and 52.4% respectively, suggesting that urine samples processed with Cobas 4800 HPV test may be useful for clinical management of HPV infection.
References
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Natural history of cervicovaginal papillomavirus infection in young women
TL;DR: An increased risk of HPV infection was significantly associated with younger age, Hispanic ethnicity, black race, an increased number of vaginal-sex partners, high frequencies of vaginal sex and alcohol consumption, anal sex, and certain characteristics of partners.
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2001 Consensus Guidelines for the Management of Women With Cervical Cytological Abnormalities
TL;DR: Management of women with atypical squamous cells (ASC) depends on whether the Papanicolaou test is subcategorized as of undetermined significance (ASC-US) or as cannot exclude high-grade squamous intraepithelial lesion (HSIL) (asc-H).
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Comparison of Three Management Strategies for Patients With Atypical Squamous Cells of Undetermined Significance: Baseline Results From a Randomized Trial
TL;DR: HC 2 testing for cancer-associated HPV DNA is a viable option in the management of women with ASCUS and has greater sensitivity to detect CIN3 or above and specificity comparable to a single additional cytologic test indicating ASCUS or above.